Facile Synthesis of 4-Substituted 2-Pyrazolin-5-Ones Under Phase Transfer Catalysis

Shiba, S. A.; Harb, N. M. S.; El‐Kassaby, M. A.; Hassan, Mohamed A.; El-Regal, Mohsen M. K. Abou

doi:10.1080/10426509508042573

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…In a plan to study C-versus O-alkylation of the pyrazoline derivatives, 3-methyl-1-phenyl-2-pyrazolin-5-one 333 was treated under PTC condition with different bromoorganic compounds such as benzyl bromide, 1,3-dibromopropane, methyl bromoacetate, bromoacetaldehyde, or diethylacetal as alkylating agents either in the absence or the presence of carbon disulphide and afforded numerous of C-or Oalkylated derivatives 334a-e, 335a-e [107] (Figure 119).…”

Section: C-alkylationmentioning

confidence: 99%

“…Sulphonylation. 4,5-Dihydro-3,5-diaryl-1-(4-fluorophenylsulphonyl)pyrazoles 341 and 2-aryl-1-(4-fluorphenylsulphonyl)indoles 343 were prepared from reaction of 4-fluorophenylsulphonyl chloride 339 with the appropriate 4,5-dihydro-3,5-diarylpyrazoles 340 or 2-arylindoles 342, via solid-liquid phase (THF/KOH/TBAB) [107] (Figure 121). N-Sulphonylation product 346 was prepared through treating 2-chloro-6,6-difluro-1,3-dioxolo[4,5-f]benzimidazole 344 with 3,5-dimethylisoxazole-4-sulphonyl chloride 345 via PTC protocol (toluene/aq.…”

Section: 2mentioning

confidence: 99%

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Synthesis and Reactions of Five-Membered Heterocycles Using Phase Transfer Catalyst (PTC) Techniques

El-Sayed

Allah

El‐Saghier

et al. 2014

Journal of Chemistry

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Phase transfer catalysts (PTCs) have been widely used for the synthesis of organic compounds particularly in both liquid-liquid and solid-liquid heterogeneous reaction mixtures. They are known to accelerate reaction rates by facilitating formation of interphase transfer of species and making reactions between reagents in two immiscible phases possible. Application of PTC instead of traditional technologies for industrial processes of organic synthesis provides substantial benefits for the environment. On the basis of numerous reports it is evident that phase-transfer catalysis is the most efficient way for generation and reactions of many active intermediates. In this review we report various uses of PTC in syntheses and reactions of five-membered heterocycles compounds and their multifused rings.

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Section: C-alkylationmentioning

confidence: 99%

Section: 2mentioning

confidence: 99%