Facile Synthesis of 3-N-Alkyl Pyrimidin-2,4-diones from N-Sulfonyloxy Maleimides and Amines

Abstract

Reaction of variously substituted N-trifluoromethanesulfonyloxy maleimides with primary amines in the presence of potassium carbonate in DMF at room temperature results in the formation of 3-N-alkyl pyrimidin-2,4-diones in good yield.

Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent

“…Their synthesis commenced with the preparation of azido precursors 12 and with the -aminosulfonamide derivative 15, obtained in 4 steps from taurine. 22 The key reaction involved the formation of the quinazolinedione core, which was performed via a Lossen rearrangement and subsequent ring closure of N-tosyloxyphthalimide 10 in presence of various amine nucleophile, 23…”