Facile synthesis of 2,4‐diamino‐6‐alkyl‐ or 6‐aryl‐pyrimidine derivatives

Wang, Xihong; Sathunuru, Ramadas; Meléndez, Víctor; Kozar, Michael P.; Lin, Ai Jeng

doi:10.1002/jhet.419

Cited by 3 publications

(2 citation statements)

References 15 publications

(23 reference statements)

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“…Wang and colleagues reported the synthesis of 2,4-diamino-6-alkyl-or 6-aryl-Pyrimidine Derivatives [84]. In attempt to develop a general method, two approaches were tried.…”

Section: Case Study 2: Synthesis Of 24-diamino-6-alkyl-(or 6-aryl-) P...mentioning

confidence: 99%

“…The researchers also reported the synthesis of 2,4,6-trisbustituted pyrimidines (108) using the commercially available 4,6-dichloro-2-methylthiopyrimidine (104) as a starting material for the sequential substitution under Suzuki conditions (phenylboronic acid in the presence of triphenylphosphine and palladium acetate) afforded the desired 4-chloro-2-methylthio-6-phenylpyrimidine (106a or 106b) in high yield [84] compared to the case when 2,4,6-trichloropyrimidine (109) was used…”

Section: Case Study 2: Synthesis Of 24-diamino-6-alkyl-(or 6-aryl-) P...mentioning

confidence: 99%

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Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines

Najajreh,

Awwad Khoury

2023

Strategies for the Synthesis of Heterocycles and Their Applications

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Diazine alkaloid (pyridazine, pyrimidine and pyrazine) scaffold, a widespread two-nitrogen containing compounds in nature (DNA, RNA, flavors, and fragrances), constitutes a central building block for wide range of pharmacological applications. Diazines are reported to exhibit antimetabolite (antifolate and), anticancer, antibacterial, antiallergic, tyrosine kinase, antimicrobial, calcium channel antagonistic, anti-inflammatory, analgesic, antihypertensive, antileishmanial, antituberculostatic, anticonvulsant, diuretic and potassium-sparing, to antiaggressive activities. Pyridazine (1,2-diazine), pyrimidine (1,3-diazine) and pyrazine (1,4-diazine) are found as mono-systems, fused or annulated in pharmaceutical, agrochemical or materials. These six-membered heterocyclic aromatic moieties defined as privileged scaffolds constitute diverse chemical structures and as such hold substantial interest for organic, medicinal and biological chemists. This chapter will focus on elaboration of the different synthetic approaches applied in preparing pharmacologically active decorated diazines with special care on pyrimidines (non-fused substituted forms) that are endowed with clinical applications. Synthetic approaches applied in preparing selected FDA approved drugs with pyrimidine as a central unit bearing different substituents will be intensively explored. Special attention will be given to novel synthetic methodologies that served molecules with improved druglikeness and ADME-Tox properties.

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“…Wang and colleagues reported the synthesis of 2,4-diamino-6-alkyl-or 6-aryl-Pyrimidine Derivatives [84]. In attempt to develop a general method, two approaches were tried.…”

Section: Case Study 2: Synthesis Of 24-diamino-6-alkyl-(or 6-aryl-) P...mentioning

confidence: 99%

Section: Case Study 2: Synthesis Of 24-diamino-6-alkyl-(or 6-aryl-) P...mentioning

confidence: 99%

Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines

Najajreh,

Awwad Khoury

2023

Strategies for the Synthesis of Heterocycles and Their Applications

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ChemInform Abstract: Facile Synthesis of 2,4‐Diamino‐6‐alkyl‐ or 6‐Aryl‐pyrimidine Derivatives.

et al. 2011

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Subindividual variability in sea pens (Octocorallia: Pennatulacea)

García-Cárdenas

2023

scimar

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Comparisons between plants and sessile modular colonial invertebrates offer interesting parallelisms between plant and animal body plans after millions of years of divergent evolution. Among these parallelisms might be the existence and distribution of intraindividual heterogeneity in organ traits, also named subindividual variability. Subindividual variability is quantitatively important and has many consequences for plant individuals, populations and communities, and for animal consumers as well. However, could a similar process of subindividual variability occur in sea pens, which have a modular architecture similar to that of plants? In the literature of marine invertebrates very little is known about the presence and magnitude of subindividual variability in modular organisms. This study provides for the first time a quantitative assessment of subindividual variability in sea pens, analysing certain biometric features of reiterated structures that presumably have some ecological function, and offers an initial comparison of quantitative levels of subindividual variation between plants and sea pens.

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Facile synthesis of 2,4‐diamino‐6‐alkyl‐ or 6‐aryl‐pyrimidine derivatives

Cited by 3 publications

References 15 publications

Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines

Synthetic Approaches for Pharmacologically Active Decorated Six-Membered Diazines

ChemInform Abstract: Facile Synthesis of 2,4‐Diamino‐6‐alkyl‐ or 6‐Aryl‐pyrimidine Derivatives.

Subindividual variability in sea pens (Octocorallia: Pennatulacea)

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