Abstract:A series of 1,3,5-oxadiazin-2-one derivatives were obtained from the intermolecular cyclization of ynamides and nitriles mediated by cheap and readily available molecular iodine under room temperature. This protocol has some distinct advantages of mild conditions, simple work-up, easily available starting materials and fast reaction rate. The structures of all products were characterized by 1 H NMR, 13 C NMR, IR and HRMS.
TfOH-mediated [4 + 2] cycloaddition of ynamides with nitriles to construct 1,2-dihydroquinazolines is realized by a direct reaction in moderate to excellent yields (up to 93%) in a stereospecific manner.
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