Facile synthesis, crystal structure, biological evaluation, and molecular modeling studies of N-((4-acetyl phenyl) carbamothioyl) pivalamide as the multitarget-directed ligand
Abstract:The crystal structure of N-((4-acetylphenyl)carbamothioyl)pivalamide (3) was synthesized by inert refluxing pivaloyl isothiocyanate (2) and 4-aminoacetophenone in dry acetone. The spectroscopic characterization (1H-NMR, 13CNMR, FT-IR) and single crystal assays determined the structure of synthesized compound (3). Systematic experimental and theoretical studies were conducted to determine the molecular characteristics of the synthesized crystal. The biological examination of (3) was conducted against a variety … Show more
“…74). 128 1-Aroyl-3-(3-chloro-2-methylphenyl)thiourea hybrids (148a-j) were synthesized as effective inhibitors of urease by Rasheed et al All synthesized compounds exhibited good inhibitory activity against jack bean urease (JBU) having IC 50 values in the range of 0.0019 ± 0.0011 to 0.0532 ± 0.9951 mM as compared to standard thiourea with IC 50 4.7455 ± 0.0545 mM. Compounds (148i and 148e) were concluded as most potent inhibitors of urease with IC 50 values 0.0019 ± 0.0011 mM and 0.0038 ± 0.0784 mM, respectively (Fig.…”
This literature update is a continuation of our efforts to compile comprehensive data on research endeavors concerning acyl thioureas over the past two years.
“…74). 128 1-Aroyl-3-(3-chloro-2-methylphenyl)thiourea hybrids (148a-j) were synthesized as effective inhibitors of urease by Rasheed et al All synthesized compounds exhibited good inhibitory activity against jack bean urease (JBU) having IC 50 values in the range of 0.0019 ± 0.0011 to 0.0532 ± 0.9951 mM as compared to standard thiourea with IC 50 4.7455 ± 0.0545 mM. Compounds (148i and 148e) were concluded as most potent inhibitors of urease with IC 50 values 0.0019 ± 0.0011 mM and 0.0038 ± 0.0784 mM, respectively (Fig.…”
This literature update is a continuation of our efforts to compile comprehensive data on research endeavors concerning acyl thioureas over the past two years.
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