Facile route to versatile nanoplatforms for drug delivery by one-pot self-assembly

Zhou, Xing; Che, Ling; Wei, Yanling; Ding, Yin; Chen, Sha; He, Hongmei; Gong, Hao; Li, Xiaohui; Zhang, Jianxiang

doi:10.1016/j.actbio.2014.01.024

Cited by 26 publications

(27 citation statements)

References 50 publications

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“…Moreover, prolonged incubation slightly decreased cell viability at the examined time points. This time‐dependent cytotoxicity should be associated with the increased necrosis and apoptosis as revealed for other nanomaterials and nanomedicines . Further examination was carried out using mouse macrophage RAW264.7, a normal cell line.…”

Section: Methodsmentioning

confidence: 99%

Biocompatible Reactive Oxygen Species (ROS)‐Responsive Nanoparticles as Superior Drug Delivery Vehicles

Zhang

Wei

Chen

et al. 2014

Adv Healthcare Materials

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114

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A novel reactive oxygen species (ROS)-responsive nanoplatform can be successfully manufactured from a ROS-triggerable β-cyclodextrin material. Extensive in vitro and in vivo studies validate that this nanoscaled system may serve as a new drug delivery vehicle with well-defined ROS-sensitivity and superior biocompatibility. This nanocarrier can be used for ROS-triggered transport of diverse therapeutics and imaging agents.

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Section: Methodsmentioning

confidence: 99%

Biocompatible Reactive Oxygen Species (ROS)‐Responsive Nanoparticles as Superior Drug Delivery Vehicles

Zhang

Wei

Chen

et al. 2014

Adv Healthcare Materials

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114

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“…In our previous studies, we discovered a one-pot and high efficient fabrication of polymer nanotherapeutics based on commercially available homopolymers (such as polyethyleneimine (PEI)) and small molecule drugs through multiple interactions mediated self-assembly, with high drug loading capacity and desirable therapeutic benefits, which showed great potential and advantages in clinical transformation as efficient oral nanocontainers for other hydrophobic drugs 38, 39 . To combine this system with PEGylation cleavable profile is expected to integrate its advantages to help clinical transformation of PEGylation cleavable nanotherapeutics.…”

Section: Introductionmentioning

confidence: 99%

Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

Zhao

Лонг

Zhang³

et al. 2017

Sci Rep

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A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellent pH-sensitivity PEGylation cleavage performance at extracellular pH of tumor microenvironment, compared to normal tissues, thereby long circulated in blood but were highly phagocytosed by tumor cells. Consequently, this smart pH-sensitive PEGylation cleavage provided an efficient strategy to target tumor microenvironment, in turn afforded superior therapeutic outcome in anti-tumor activity.

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“…[1] The ability of self-complementary DNAs to base pair into predictable structures has allowed the creation of aw ide variety of nanoscale DNA objects in two-and three-dimensions. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] These self-assembled DNA constructs are finding increasing uses as biomaterials, for controlled drug deliverya nd release, [17][18][19][20][21][22] and as an interfacial material between biological and inorganic realms. [23][24][25][26][27][28] The earliest goal of the DNA nanotechnology field was the creation of 3D DNA crystals for use as macromolecular scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Enhancing DNA Crystal Durability through Chemical Crosslinking

Zhang

Paukstelis

2016

ChemBioChem

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Three-dimensional (3D) DNA crystals have been envisioned as a powerful tool for the positional control of biological and non-biological arrays on the nanoscale. However, most DNA crystals contain short duplex regions that can result in low thermal stability. Additionally, because DNA is a polyanion, DNA crystals often require high cation concentrations to maintain their integrity. Here, we demonstrate that a DNA alkylating mustard, bis(2-chloroethyl)amine, can form interstrand crosslinks within a model 3D DNA crystal. The crosslinking procedure did not alter crystal X-ray diffraction properties, but it did significantly improve the overall stability of the crystals under a variety of conditions. Crosslinked crystals showed enhanced stability at elevated temperature and were stable at Mg(2+) concentrations as low as 1 mm. Remarkably, the crosslinked crystals showed significant resistance to DNase I treatment, while also having improved longevity in tissue culture mediums. Characterization of the crosslinked species suggest that there are multiple crosslinking sites, but that the most prevalent interstrand crosslink involves an unpaired 3'-terminal guanosine residue. The improved stability of these DNA crystals suggests that simple treatment with alkylating reagents might be sufficient to stabilize crystals and other DNA constructs for improved functionality in biological and non-biological applications.

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Facile route to versatile nanoplatforms for drug delivery by one-pot self-assembly

Cited by 26 publications

References 50 publications

Biocompatible Reactive Oxygen Species (ROS)‐Responsive Nanoparticles as Superior Drug Delivery Vehicles

Biocompatible Reactive Oxygen Species (ROS)‐Responsive Nanoparticles as Superior Drug Delivery Vehicles

Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

Enhancing DNA Crystal Durability through Chemical Crosslinking

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