Abstract:A protocol is reported which allows preparation of electron-rich benzimidazole derivatives in good yield. The reaction proceeds directly from dinitrobenzene derivatives without need of isolation of air-sensitive diamines.Benzimidazole-4,7-diones (3) are compounds of interest due to their potential use as anticancer and antifungal agents. [1][2][3][4][5][6][7][8] They are typically prepared by oxidation of the corresponding 4,7-dimethoxybenzimidazoles (2), which in turn are prepared from 3,6-dimethoxybenzene-1,… Show more
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