Facile preparation of η6-p-cymene ruthenium diphosphine complexes. Crystal structure of [(η6-p-cymene)Ru(dppf)Cl]PF6

Cytotoxicity of half sandwich ruthenium(II) complexes with strong hydrogen bond acceptor ligands and their mechanism of action

“…The bisphosphine mono oxide ligands and the ruthenium complexes were synthesized following literature procedures [39][40][41][42][43].…”

“…The complexes were characterized by spectroscopic and analytical means and the details are found in the Supporting information. Half sandwich complexes of Ru(II) stabilized by cymene having one or two dissociating chloride ligands have been synthesized from these precursors [40][41][42][43]. They can be activated at low chloride concentrations to form [Ru-OH 2 ] + which can react with DNA by forming a bond with one of the purine bases, most often guanine.…”

Comparative reactivity studies of dppf-containing CpRuII and (C6Me6)RuII complexes towards different donor ligands (dppf=1,1′-bis(diphenylphosphino)ferrocene)

“…d 6 Ru II complexes containing dppf are known [7] with about 20 crystallographic reports. These include threelegged piano-stool structures [(C 5 R 5 )Ru(dppf)H] (R ¼ Me [8]; R ¼ H [9]), [(g 6 -arene)Ru(dppf)Cl]PF 6 (arene ¼ HMB [10], p-cymene [11]), [(g 6 -Me 4 -C 6 H 2 )RuCl 2 ] 2 (ldppf) Á CH 2 Cl 2 [10], [CpRu(dppf)(CBC-(C 5 H 4 NH))-W(CO) 4 (PPh 3 )] [12], [TpRu(dppf)Cl] and [Tp(dppf) Ru@C@C@CPh 2 ]SbF 6 [13] (Tp ¼ tris(pyrazolyl)borate), a four-legged piano-stool complex [Cp*Ru(dppf)(g 2 -O 2 )]BF 4 [14], and other octahedral structures [Ru-(dppf)(bipy) 2 ](PF 6 ) 2 [15], [Ru(dppf)(CO)(PPh 3 )(Cl)H] [16], [Ru(dppf)(CO)(NCMe)(PPh 3 )H]BF 4 Á EtOH [17], [Ru(dppf)(C 3 H 5 )(C 6 F 5 O 2 )] [18], [RuCl(CO)(dppf) (PPh 3 )]BF 4 and [RuCl(CO)(dppf)(CH 3 CN)] 2 (BF 4 ) 2 [19]. In this paper we report complexes obtained by chloro substitution in [CpRu(dppf)Cl] (1) and [(HMB)Ru(dppf)Cl](PF 6 ) (3), and structural variations in response to the aromatic ring ligand.…”

Synthesis and in vitro Anticancer Activity of Ruthenium–Cymene Complexes with Cyclohexyl‐Functionalized Ethylenediamine‐N,N′‐diacetate‐Type Ligands

“…[28] (S,S)-Ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid dihydrochloride and corresponding esters were obtained as described. [16] Solvents were obtained commercially and used without further purification.…”