Facile preparation of tetrahydro-5H-pyrido[1,2,3-de]-1,4-benzoxazines via reductive cyclization of 2-(8-quinolinyloxy)ethanones and their antioxidant activity

Patil, Viraj P.; Markad, Vijay L.; Kodam, Kisan M.; Waghmode, Suresh B.

doi:10.1016/j.bmcl.2013.09.088

Cited by 25 publications

(13 citation statements)

References 46 publications

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“…High levels of free radicals can cause damage to biomolecules such as lipids, proteins, enzymes and DNA in cells and tissues. This may result in many diseases such as: cancer, diabetes, cardiovascular and autoimmune diseases, and neurodegenerative disorders, aging, and other diseases through the violent reactivity of the free radicals [3,4,5]. …”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties

Bărbuceanu

Ilieș

Şaramet

et al. 2014

IJMS

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In the present investigation, new hydrazinecarbothioamides 4–6 were synthesized by reaction of 4-(4-X-phenylsulfonyl)benzoic acids hydrazides (X= H, Cl, Br) 1–3 with 2,4-difluorophenyl isothiocyanate and further these were treated with sodium hydroxide to obtain 1,2,4-triazole-3-thione derivatives 7–9. The reaction of 7–9 with α-halogenated ketones, in basic media, afforded new S-alkylated derivatives 10–15. The structures of the synthesized compounds have been established on the basis of 1H-NMR, 13C-NMR, IR, mass spectral studies and elemental analysis. The antioxidant activity of all compounds has been screened. Hydrazinecarbothioamides 4–6 showed excellent antioxidant activity and 1,2,4-triazole-3-thiones 7–9 showed good antioxidant activity using the DPPH method.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties

Bărbuceanu

Ilieș

Şaramet

et al. 2014

IJMS

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“…[Eq. (78)] . These authors also explored the scope of this intermolecular reductive cyclization and studied the antioxidant activities of the products.…”

Section: Applications Of Pd/cmentioning

confidence: 99%

Development of the Applications of Palladium on Charcoal in Organic Synthesis

Liu

Astruc

2018

Adv Synth Catal

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Palladium on charcoal( Pd/C)h as lots of salient merits:( i) it is ac heap andc ommercial source of palladium, (ii)i ts hows efficientc atalytic activity even without ligands,( iii)a saheterogeneous catalyst it is easily recycledm any times by simple filtration,a nd (iv) it is applicablet oag reat number of reactions and substrates,a lthough it is eventually less efficient than homogeneous Pd catalysts containing some sophisticated ligands.T hisr eview recalls the main background ands ummarizes the progress made essentially during the last twelve years in Pd/C-catalyzed organic synthesis since the reviews by Felpins group andSekiin2 006.

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“…These species, which are constantly formed in the human body, can become toxic when generated in excess or in the presence of a deficiency in naturally occurring antioxidant defenses. High levels of free radicals can cause damage to biomolecules such as lipids, proteins, enzymes and DNA in cells and tissues …”

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical investigations of the antioxidant activity of 2,2′‐methylenebis(4,6‐dialkylphenol) compounds

Zoubi

Karabet

Bandakji

et al. 2016

Applied Organom Chemis

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The antioxidant activity of two primary antioxidants, 2,2′‐methylenebis(4‐methyl‐6‐tert‐butylphenol) (MMBPH2) and 2,2′‐methylenebis(4,6‐di‐tert‐butylphenol) (MDBPH2), has been studied using the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) method. The synthesized compounds have been successfully characterized systematically using elemental analyses, infrared, 1H NMR and 13C NMR spectra and GC–MS. Importantly, it has been found that the compound MMBPH2 in particular is more active in DPPH radical scavenging. In addition, density functional theory calculations (B3LYP) have been used to predict the antioxidant activity and predict structural geometries of the compounds in the gas phase.

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Facile preparation of tetrahydro-5H-pyrido[1,2,3-de]-1,4-benzoxazines via reductive cyclization of 2-(8-quinolinyloxy)ethanones and their antioxidant activity

Cited by 25 publications

References 46 publications

Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties

Synthesis and Antioxidant Activity Evaluation of New Compounds from Hydrazinecarbothioamide and 1,2,4-Triazole Class Containing Diarylsulfone and 2,4-Difluorophenyl Moieties

Development of the Applications of Palladium on Charcoal in Organic Synthesis

Experimental and theoretical investigations of the antioxidant activity of 2,2′‐methylenebis(4,6‐dialkylphenol) compounds

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