Facile preparation of pH-responsive k-Carrageenan/tramadol loaded UiO-66 bio-nanocomposite hydrogel beads as a nontoxic oral delivery vehicle

Javanbakht, Siamak; Shadi, Mehrdad; Mohammadian, Reza; Shaabani, Ahmad; Amini, Mostafa M.; Pooresmaeil, Malihe; Salehi, Roya

doi:10.1016/j.jddst.2019.101311

Cited by 43 publications

(20 citation statements)

References 62 publications

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“…For both cell lines, no significant cytotoxic effect was observed [ 31 ]. Moreover, pH-responsive k-Carrageenan/tramadol loaded UiO-66 bio-nanocomposite hydrogel beads proposed by Javanbakht et al did not reduce the viability of human colon cells [ 32 ]. Another safe and effective carrier was described by Nia et al The fabricated pH-sensitive carboxymethylcellulose-based bio-nanocomposite hydrogel beads, designed as a controlled amoxicillin nanocarrier for colonic bacterial infection treatment, did not reveal cytotoxicity to human umbilical vein endothelial cells (HUVECs) [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

et al. 2021

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This study aimed to characterize the hydrogel micro- and macro-particles designed to deliver curcumin to human colon cancer cells (LoVo). Six series of vehicles based on sodium alginate (micro- and macro-particles, uncoated, coated with chitosan or gelatin) were synthesized. The uncoated microparticles were fabricated using an emulsion-based technique and the uncoated macroparticles with an extrusion technique, with both coupled with ionotropic gelation. The surface morphology of the particles was examined with scanning electron microscopy and the average size was measured. The encapsulation efficiency, moisture content, and swelling index were calculated. The release of curcumin from the particles was studied in an experiment simulating the conditions of the stomach, intestine, and colon. To evaluate the anticancer properties of such targeted drug delivery systems, the cytotoxicity of both curcumin-loaded and unloaded carriers to human colon cancer cells was assessed. The microparticles encapsulated much less of the payload than the macroparticles and released their content in a more prolonged manner. The unloaded carriers were not cytotoxic to LoVo cells, while the curcumin-loaded vehicles impaired their viability—more significantly after incubation with microparticles compared to macroparticles. Gelatin-coated or uncoated microparticles were the most promising carriers but their potential anticancer activity requires further thorough investigation.

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Section: Resultsmentioning

confidence: 99%

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

et al. 2021

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“…Based on our previous studies on biomedical platforms, − the objective of the present work is to synthesize the pH-responsive photoluminescent nanocarrier using a more efficient drug imprinting strategy via an innovative combination of PHEMA with GQDs. We present the development of PLMIPs for the imprinting of an anticancer DOX drug that is used as a typical anticancer drug in chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin Imprinted Photoluminescent Polymer as a pH-Responsive Nanocarrier

Javanbakht

Saboury

Shaabani

et al. 2020

ACS Appl. Bio Mater.

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In this work, an innovative doxorubicin (DOX) imprinted photoluminescent polymer via the precipitation free-radical polymerization strategy was developed based on graphene quantum dots as a pH-responsive nanocarrier. The prepared materials were characterized by Fourier transform infrared, scanning electron microscopy, photoluminescence, and dynamic light scattering techniques. Binding kinetics of DOX established specific recognition binding sites in the photoluminescent nanoscale molecularly imprinted polymer (PLMIP) structure. In vitro drug release behaviors exhibited a pH-controlled release in a sustained manner for the prepared photoluminescent nanocarriers. Due to the presence of pseudopeptide skeletons in the nanocarrier and a positively charged structure, the cytotoxicity study indicated that a DOX-loaded nanocarrier against human lung adenocarcinoma A549 cell lines has notable cytotoxicity. According to the obtained results, the prepared pH-responsive PLMIP has the potential to be employed as an anticancer and biodetection platform.

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“…Until now, different systems have been prepared as DDSs to deliver the wanted drug molecules to the special site of the body. Among them, today's, nanotechnology‐based DDSs have received much more consideration because of their sustainability, the potential for improving drug solubility, stimuli‐sensitive drug release pattern, circulation time, reducing the drug resistance, and low side effects 96–100 . CA is one of the nontoxic biomaterials that is commonly used in the synthesis of various NPs or their modification.…”

Section: Ca‐based Ddssmentioning

confidence: 99%

“…Among them, today's, nanotechnology-based DDSs have received much more consideration because of their sustainability, the potential for improving drug solubility, stimuli-sensitive drug release pattern, circulation time, reducing the drug resistance, and low side effects. [96][97][98][99][100] CA is one of the nontoxic biomaterials that is commonly used in the synthesis of various NPs or their modification. This biomaterial plays several beneficial roles in the nanoscience which prevention from the NPs agglomeration, increasing the stability in the biological medium, cosurfactant, template, increasing the drug loading ability through the introduction of the new carboxylic groups on the structure, capping agent, reducing agent in the NPs synthesis step, as well as, ameliorate biocompatibility are some of them.…”

Section: Ca-based Nanoplatformsmentioning

confidence: 99%

Application or function of citric acid in drug delivery platforms

Pooresmaeil

Javanbakht

Namazi

et al. 2021

Medicinal Research Reviews

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Nontoxic materials with natural origin are promising materials in the designing and preparation of the new drug delivery systems (DDSs). Today's, citric acid (CA) has attracted a great deal of attention because of its special features; green nature, biocompatibility, low price, biodegradability, and commercially available property. So, CA has been employed in the preparation of the various platforms to induce a suitable property on their structure. Recently, several research groups investigated the CA‐based platforms in different forms like tablets, dendrimers, hyperbranched polymers, (co)polymer, hydrogels, and nanoparticles as efficient DDSs. By considering an increasing amount of published articles in this field, for the first time, in this review, an overview of the published works regarding CA applications in the design of various DDSs is presented with a detailed and insightful discussion.

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Facile preparation of pH-responsive k-Carrageenan/tramadol loaded UiO-66 bio-nanocomposite hydrogel beads as a nontoxic oral delivery vehicle

Cited by 43 publications

References 62 publications

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

Microparticles vs. Macroparticles as Curcumin Delivery Vehicles: Structural Studies and Cytotoxic Effect in Human Adenocarcinoma Cell Line (LoVo)

Doxorubicin Imprinted Photoluminescent Polymer as a pH-Responsive Nanocarrier

Application or function of citric acid in drug delivery platforms

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