Facile preparation of highly luminescent composites by polymer embedding of carbon dots derived from N-hydroxyphthalimide

Stan, Corneliu Sergiu; Horlescu, Petronela; Ursu, Laura; Popa, Marcel; Albu, Cristina

doi:10.1007/s10853-016-0320-y

Cited by 22 publications

(28 citation statements)

References 31 publications

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“…Nanomaterials have been stated to be one of the most promising platforms for cancer imaging and drug/gene delivery since they have the ability to combine diagnosis and therapy into one material 23 – 35 . We previously synthesized and characterised Carbon Dots from imide precursors and these Carbon Dots exhibited enhanced fluorescent emission relatively to other described Carbon Dots at that time 14 . In the present work, we extend our previous investigation on putative anti-tumoral properties of CD-NHF in both in vitro and in vivo systems.…”

Section: Discussionmentioning

confidence: 96%

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NHF-derived carbon dots: prevalidation approach in breast cancer treatment

Tiron

Luta

Butura

et al. 2020

Sci Rep

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Metastatic breast cancer dominates the female cancer-related mortality. Tumour-associated molecules represents a crucial for early disease detection and identification of novel therapeutic targets. Nanomaterial technologies provide promising novel approaches to disease diagnostics and therapeutics. In the present study we extend the investigations of antitumoral properties of Carbon Dots prepared from N -hydroxyphthalimide (CD-NHF) precursor. We evaluate the effect of CD-NHF on tumour cell migration and invasion in vitro and their impact on tumour progression using an in vivo model. Furthermore, we investigate the molecular mechanisms involved in CD-NHF antitumour effects. In vivo mammary tumours were induced in Balb/c female mice by injecting 4T1 cells into the mammary fat pad. Conditional treatment with CD-NHF significantly impair both migration and invasion of metastatic breast cancer cells. The presence of CD-NHF within the 3D cell cultures strongly inhibited the malignant phenotype of MDA-MB-231, 4T1 and MCF-7 cells in 3D culture, resulting in culture colonies lacking invasive projections and reduction of mammospheres formation. Importantly, breast tumour growth and metastasis dissemination was significantly reduced upon CD-NHF treatments in a syngeneic mouse model and is associated with down-regulation of Ki67 and HSP90 expression. CD-NHF nanostructures provide exciting perspective for improving treatment outcome in breast cancer.

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Section: Discussionmentioning

confidence: 96%

“…Nano-technologies, has provided very exciting modalities for optimizing treatment outcomes in cancer and other types of disease. In this paper CD-NHF were prepared in a modified way of previously described method 14 (e.g. 10 min pyrolysis instead of 20) and their effect was investigated in different cancer micro-environments.…”

Section: Introductionmentioning

confidence: 99%

NHF-derived carbon dots: prevalidation approach in breast cancer treatment

Tiron

Luta

Butura

et al. 2020

Sci Rep

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“…Knowing that the orbitals can be defined as the regions of space around the nucleus in which the probability of finding the electron has a maximum value, analyzing, by comparison, the figures 6a and 6b, the modification of electron density distribution can be observed: from the main chain to the branch chain and towards one terminal residue of the polymer, determining thus a weak affinity for chemical reactions for the atoms with no drawn orbitals. This indicates that in the complexation reaction [22], the bonding appears between the lanthanide ion and the oxygen atoms of one terminal residuu.…”

Section: Spectral Properties Of Hema and Poly(hema) In Electrically Cmentioning

confidence: 96%

“…Luminescent polymer complexes based on poly(2hydroxy ethyl)methacrylate (P-HEMA) and Eu 3+ were prepared (for details, see [22]). XPS and FT-IT investigations revealed that the lanthanide ion bonds to the HEMA structure by: (1) a covalent bond with the oxygen atom in the hydroxyl group located on the side of the HEMA monomer chain and (2) a coordinative bond with the oxygen atom in the carbonyl group.…”

Section: Experimental Partmentioning

confidence: 99%

Spectral Properties of HEMA/poly(HEMA) as Ligand in Luminescent Europium Based Complexes Through Computational Investigation

Băcăiță¹,

Stan²,

Agop³

et al. 2018

Rev. Chim.

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“…Those methods can be classified into “bottom‐up” and “top‐down” routes . Additionally, their applications range from energy‐related devices to biology and composite films . CQD particles were also applied in UV‐shielding film preparation because of their broad UV region and strong absorbance …”

Section: Introductionmentioning

confidence: 99%

Synthesis of carbon quantum dots to fabricate ultraviolet‐shielding poly(vinylidene fluoride) films

Dong

Xiong

Liu

et al. 2019

J of Applied Polymer Sci

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The paper presents a simple and effective approach to fabricating a poly(vinylidene fluoride) (PVDF) film with excellent ultraviolet (UV) shielding performance. Carbon quantum dots (CQDs) with a highly UV absorbing property were made via a hydrothermal reaction and were then added to a poly(vinyl alcohol) (PVA) solution. The PVDF membrane pretreated with an alkaline solution was immersed in the prepared CQD/PVA solution to coat a UV‐shielding layer on the film surface. Fourier transform infrared spectroscopy, X‐ray photoelectron spectrometry, X‐ray diffraction, transmission electron microscopy, and UV–visible spectrophotometry were applied to study the structure, morphology, and optical performance of the CQD particles. The stability and UV‐shielding performance of the obtained PVDF‐OH@CQDs/PVA composite film were further investigated. The results showed that the CQD particles with diameter of 18 nm could be well dispersed in solution. Additionally, the CQDs had fairly high UV absorbance, and the PVDF‐OH@CQDs/PVA composite film could shield the UV light completely. The method described in this paper is a promising one for fabricating UV‐shielding composite films. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47555.

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Facile preparation of highly luminescent composites by polymer embedding of carbon dots derived from N-hydroxyphthalimide

Cited by 22 publications

References 31 publications

NHF-derived carbon dots: prevalidation approach in breast cancer treatment

NHF-derived carbon dots: prevalidation approach in breast cancer treatment

Spectral Properties of HEMA/poly(HEMA) as Ligand in Luminescent Europium Based Complexes Through Computational Investigation

Synthesis of carbon quantum dots to fabricate ultraviolet‐shielding poly(vinylidene fluoride) films

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