Facile Preparation of Doxorubicin‐Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy

Liu, Fuyao; He, Xiuli; Lei, Zhen; Liu, Liang; Zhang, Junping; You, Hongpeng; Zhang, Huimao; Wang, Zhenxin

doi:10.1002/adhm.201400676

Cited by 171 publications

(112 citation statements)

References 72 publications

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“…In that regard, the distinct chemical features of DOX, such as its hydrophobicity and cationic charge, have been exploited for loading DOX into delivery cargos such as the hydrophobic core of liposomes, polymeric micelles, or nanoparticles 18,33,34,35,36,37 . Further, DOX has been adsorbed on the surface of carbon nanomaterials and intercalated into specific DNA sequences via π-π interaction 17,38,39,40,41 . Charge interaction with negatively charged materials such as the surface of silica or polyanions is another common strategy utilized for loading DOX 42,43 .…”

Section: Introductionmentioning

confidence: 99%

Self-assembled nanocomplex between polymerized phenylboronic acid and doxorubicin for efficient tumor-targeted chemotherapy

et al. 2017

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Since the discovery that nano-scaled particulates can easily be incorporated into tumors via the enhanced permeability and retention (EPR) effect, such nanostructures have been exploited as therapeutic small molecule delivery systems. However, the convoluted synthetic process of conventional nanostructures has impeded their feasibility and reproducibility in clinical applications. Herein, we report an easily prepared formulation of self-assembled nanostructures for systemic delivery of the anti-cancer drug doxorubicin (DOX). Phenylboronic acid (PBA) was grafted onto the polymeric backbone of poly(maleic anhydride). pPBA-DOX nanocomplexes were prepared by simple mixing, on the basis of the strong interaction between the 1,3-diol of DOX and the PBA moiety on pPBA. Three nanocomplexes (1, 2, 4) were designed on the basis of [PBA]:[DOX] molar ratios of 1:1, 2:1, and 4:1, respectively, to investigate the function of the residual PBA moiety as a targeting ligand. An acid-labile drug release profile was observed, owing to the intrinsic properties of the phenylboronic ester. Moreover, the tumor-targeting ability of the nanocomplexes was demonstrated, both in vitro by confocal microscopy and in vivo by fluorescence imaging, to be driven by an inherent property of the residual PBA. Ligand competition assays with free PBA pre-treatment demonstrated the targeting effect of the residual PBA from the nanocomplexes 2 and 4. Finally, the nanocomplexes 2 and 4, compared with the free DOX, exhibited significantly greater anti-cancer effects in vitro and even in vivo. Our pPBA-DOX nanocomplex enables a new paradigm for self-assembled nanostructures with potential biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Self-assembled nanocomplex between polymerized phenylboronic acid and doxorubicin for efficient tumor-targeted chemotherapy

et al. 2017

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“…The NIR trigger may be related to the π-π stacking-based drug delivery system in order to contribute to the control of drug dosage at a specific time. 30 The cell viability was measured to investigate the therapeutic effect with different treatments in vitro. Three kinds of PCa cell lines PC3, DU145, and LnCap were used.…”

mentioning

confidence: 99%

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Zhang¹,

Zhao²,

Guo³

et al. 2017

IJN

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Dopamine is a neurotransmitter commonly used in clinical treatment. Polydopamine (PDA) has excellent histocompatibility and biosafety and can efficiently convert near-infrared reflection (NIR) to thermal energy. In this study, PDA was used as a promising carrier, and pH-responsive polymer-coated drug-loaded PDA nanoparticles (NPs; doxorubicin@ poly(allylamine)-citraconic anhydride [Dox@PAH-cit]/PDA NPs) were developed. As expected, the Dox@PAH-cit/PDA NPs exhibited excellent photothermal efficiency. In addition, at a low pH condition, the loaded Dox was released from the NPs due to the amide hydrolysis of PAH-cit. Upon NIR exposure (808 nm), the temperature of the NP solution rapidly increases to kill tumor cells. Compared with unbound chemotherapy drugs, the NPs have a stronger cell uptake ability. In vivo, the PDA NPs were able to efficiently accumulate at the tumor location. After intravenous administration and NIR exposure, tumor growth was significantly inhibited. In summary, the present investigation demonstrated that the Dox@PAH-cit/PDA NPs presented highly effective photothermal chemotherapy for prostate cancer.

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“…[126, 128] Structure, fabrication, characteristics and optical imaging applications of UCNPs have recently been reviewed in excellent articles. [126–131] Owing to the well-established synthetic procedures and facile surface chemistries, UCNPs are increasingly being employed for diverse applications such as cell tracking [132], small animal imaging [130], drug delivery [133], photothermal [134], photodynamic [133] and combination therapies. [135, 136]…”

Section: Radiolabeled Nanomaterials For Cancer Theranosticsmentioning

confidence: 99%

Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics

Goel

England

Chen

et al. 2017

Advanced Drug Delivery Reviews

159

104

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Development of novel imaging probes for cancer diagnosis is critical for early disease detection and management. The past two decades have witnessed a surge in the development and evolution of radiolabeled nanoparticles as a new frontier in personalized cancer nanomedicine. The dynamic synergism of positron emission tomography (PET) and nanotechnology combines the sensitivity and quantitative nature of PET with the multifunctionality and tunability of nanomaterials, which can help overcome certain key challenges in the field. In this review, we discuss the recent advances in radionanomedicine, exemplifying the ability to tailor the physicochemical properties of nanomaterials to achieve optimal in vivo pharmacokinetics and targeted molecular imaging in living subjects. Innovations in development of facile and robust radiolabeling strategies and biomedical applications of such radionanoprobes in cancer theranostics are highlighted. Imminent issues in clinical translation of radiolabeled nanomaterials are also discussed, with emphasis on multidisciplinary efforts needed to quickly move these promising agents from bench to bedside.

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Facile Preparation of Doxorubicin‐Loaded Upconversion@Polydopamine Nanoplatforms for Simultaneous In Vivo Multimodality Imaging and Chemophotothermal Synergistic Therapy

Cited by 171 publications

References 72 publications

Self-assembled nanocomplex between polymerized phenylboronic acid and doxorubicin for efficient tumor-targeted chemotherapy

Self-assembled nanocomplex between polymerized phenylboronic acid and doxorubicin for efficient tumor-targeted chemotherapy

Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles

Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics

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