Facile preparation of coating fluorescent hollow mesoporous silica nanoparticles with pH-sensitive amphiphilic diblock copolymer for controlled drug release and cell imaging

Xiao, Mao; Chen, Dongyun; Li, Najun; Xu, Qingfeng; Ge, Jian‐Feng; Li, Hua; Yang, Bai-Xia; Xu, Yu-Jie; Lu, Jianmei

doi:10.1039/c2sm07320j

Cited by 51 publications

(32 citation statements)

References 49 publications

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“…Current efforts are focusing on optimizing the pore parameters and the yield of mesoporous structures by changing material ratios or fabrication parameters, such as pH [34,35] and synthesis temperature [36]. From a technical point of view, an insight into the micelle organization mechanism could contribute to an improvement in silica structure including stability, pore size and volume.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery

She

Chen

Velleman

et al. 2015

Journal of Colloid and Interface Science

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Section: Introductionmentioning

confidence: 99%

Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery

She

Chen

Velleman

et al. 2015

Journal of Colloid and Interface Science

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“…Therefore, on increasing the thickness of meso-silica layer over magnetite clusters, a higher amount of drug could be loaded. The drug-loading capacity of our composite nanoparticles is comparable to the drug-loading capacity of pure mesoporous silica nanoparticles reported by Mei et al [21]. Table 1 Preparation conditions of the Fe3O4@mSiO2 samples, their texture properties and drug holding capacities Figure 6 shows the release profiles of the ibuprofen-loaded SG-1, SG-2, and SG-3 samples up to 72 hours in SBF solution.…”

Section: Figmentioning

confidence: 69%

“…Therefore, it is necessary to functionalize magnetite nanoparticles modifying their surface characteristics or cover them properly by another biocompatible material to avoid these disadvantages [15][16][17][18]. Frequently, mesoporous silica (meso-silica) has been utilized as vehicle for the delivery of special drugs [19][20][21] due its good biocompatibility in human body and high specific surface area (high drug loading capacity). However, the problem arises when we need to bring the drug to a specific site using meso-silica as vehicle.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Fe3O4@mSiO2 Core-Shell Composite Nanoparticles for Drug Delivery Applications

Madrid¹,

Pal²,

Kang³

et al. 2016

Nano Online

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(http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.We report the synthesis of Fe3O4@mSiO2 nanostructures of different meso-silica (mSiO2) shell thickness, their biocompatibility and behaviors for loading and release of a model drug ibuprofen. The composite nanostructures have superparamagnetic magnetite cores of 208 nm average size and meso-silica shells of 15 to 40 nm thickness. A modified Stöber method was used to grow the meso-silica shells over the hydrothermally grown monodispersed magnetite particles. The composite nanoparticles show very promising drug holding and releasing behaviors, which depend on the thickness of meso-silica shell. The biocompatibility of the meso-silica-coated and uncoated magnetite nanoparticles was tested through cytotoxicity assay on breast cancer (MCF-7), ovarian cancer (SKOV3), normal human lung fibroblasts MRC-5, and IMR-90 cells. The high drug holding capacity and reasonable biocompatibility of the nanostructures make them ideal agents for targeted drug delivery applications in human body.

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“…The IR spectrum of the Fe 3 O 4 @SiO 2 MNPs contained two absorption bands at 797 and 1095 cm −1 corresponding to the asymmetrical and symmetrical vibration modes of the Si− O−Si bond, 33 respectively ( Figure S1B). Additionally, the band at 948 cm −1 representing Si−OH 34 Figure S1C). The results confirmed that an alumina layer was successfully coated on the surface of the MNPs.…”

Section: ■ Results and Discussionmentioning

confidence: 97%

Magnetic Nanoparticle-Based Platform for Characterization of Shiga-like Toxin 1 from Complex Samples

Kuo

Chang

et al. 2015

Anal. Chem.

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Foodborne illness outbreaks resulting from contamination of Escherichia coli O157:H7 remain a serious concern in food safety. E. coli O157:H7 can cause bloody diarrhea, hemolytic uremic syndrome, or even death. The pathogenicity of E. coli O157:H7 is mainly caused by the expression of Shiga-like toxins (SLTs), i.e., SLT-1 and SLT-2. SLTs are pentamers composed of a single A and five B subunits. In this study, we propose a magnetic nanoparticle (MNP)-based platform to rapidly identify SLT-1 from the complex cell lysate of E. coli O157:H7. The core of the MNPs is made of iron oxide, whereas the surface of the core is coated with a thin layer of alumina (Fe3O4@Al2O3 MNPs). The Fe3O4@Al2O3 MNPs are functionalized with pigeon ovalbumin (POA), which contains Gal-α(1→4)-Gal-β(1→4)-GlcNAc termini that can bind SLT-1B selectively. Furthermore, POA is a phosphate protein. Thus, it can be easily immobilized on the surface of the Fe3O4@Al2O3 MNPs through aluminum phosphate chelation under microwave heating within 1.5 min. The generated POA-Fe3O4@Al2O3 MNPs are capable of effectively enriching SLT-1B from complex cell lysates simply by pipetting 20 μL of the sample in and out of the tip in a vial for ∼1 min. To release SLT-1 from the MNPs, Gal-α(1→4)-Gal disaccharides were used for displacement. The released target species are sufficient to be identified by matrix-assisted laser desorption/ionization mass spectrometry. Although the sample volume used in this approach is small (20 μL) and the enrichment time is short (1 min), the selectivity of this approach toward SLT-1B is quite good. We have demonstrated the effectiveness of this approach for rapid determination of the presence of SLT-1 from complex cell lysates and ham/juice samples based on the detection of SLT-1B.

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Facile preparation of coating fluorescent hollow mesoporous silica nanoparticles with pH-sensitive amphiphilic diblock copolymer for controlled drug release and cell imaging

Cited by 51 publications

References 49 publications

Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery

Fabrication of high specificity hollow mesoporous silica nanoparticles assisted by Eudragit for targeted drug delivery

Fabrication of Fe3O4@mSiO2 Core-Shell Composite Nanoparticles for Drug Delivery Applications

Magnetic Nanoparticle-Based Platform for Characterization of Shiga-like Toxin 1 from Complex Samples

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