Facile preparation of biocompatible macroporous chitosan hydrogel by hydrothermal reaction of a mixture of chitosan-succinic acid-urea

Govindaraj, Prabha; Narayanan, Abathodharanan; Ravishankar, K.; Dhamodharan, R.

doi:10.1016/j.msec.2019.109845

Cited by 18 publications

(8 citation statements)

References 36 publications

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“…The PXRD patterns of collagen, chitosan and the selected scaffolds (SC3-2 and SCGL3-2) are illustrated in Figure 4B. PXRD of pure chitosan displayed a strong diffraction peak at 2θ = 19.79 • [68], while collagen showed one broad peak at 2θ = 22 • . This broad peak in collagen is related to the diameter of the triple-helix chain of the collagen molecule [69].…”

Section: Powder X-ray Diffraction (Pxrd)mentioning

confidence: 99%

Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

et al. 2021

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Skin restoration following full-thickness injury poses significant clinical challenges including inflammation and scarring. Medicated scaffolds formulated from natural bioactive polymers present an attractive platform for promoting wound healing. Glibenclamide was formulated in collagen/chitosan composite scaffolds to fulfill this aim. Glibenclamide was forged into nanocrystals with optimized colloidal properties (particle size of 352.2 nm, and polydispersity index of 0.29) using Kolliphor as a stabilizer to allow loading into the hydrophilic polymeric matrix. Scaffolds were prepared by the freeze drying method using different total polymer contents (3–6%) and collagen/chitosan ratios (0.25–2). A total polymer content of 3% at a collagen/chitosan ratio of 2:1 (SCGL3-2) was selected based on the results of in vitro characterization including the swelling index (1095.21), porosity (94.08%), mechanical strength, rate of degradation and in vitro drug release. SCGL3-2 was shown to be hemocompatible based on the results of protein binding, blood clotting and percentage hemolysis assays. In vitro cell culture studies on HSF cells demonstrated the biocompatibility of nanocrystals and SCGL3-2. In vivo studies on a rat model of a full-thickness wound presented rapid closure with enhanced histological and immunohistochemical parameters, revealing the success of the scaffold in reducing inflammation and promoting wound healing without scar formation. Hence, SCGL3-2 could be considered a potential dermal substitute for skin regeneration.

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Section: Powder X-ray Diffraction (Pxrd)mentioning

confidence: 99%

Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

et al. 2021

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“…(not confirmed) urea-isocyanate [77] physical( pH change) or -NH-CO-NH-, -NH-CO-NH 2 ac hemical cross-linker or ap hysical coagulator by thermal decomposition. [77,78] Them echanical properties of wet gels and the final aerogels are strongly affected by the degree of cross-linking, which was investigated in few cases using IR and NMR analyses,and/or ninhydrin assays. [35,36,79] In addition, one must pay careful attention to the starting solution.…”

Section: Cross-linkermentioning

confidence: 99%

Chemistry of Chitosan Aerogels: Three‐Dimensional Pore Control for Tailored Applications

et al. 2020

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Chitosan is an abundant biopolymer derived from food waste with attractive properties, particularly its high biocompatibility and easy chemical processability. Here, we review the rapidly expanding literature on chitosan‐based porous materials with a focus on the gelation mechanisms, the three‐dimensional multiscale structural control, and the diverse chemical functionality not accessible by other biopolymers. The properties vary widely: from supercritically dried, mesoporous chitosan aerogels to very light, freeze‐dried macroporous scaffolds. Porous chitosan displays impressive performance at the laboratory scale, but the highly (meso)porous nature amplifies not only the beneficial functionality of chitosan, but also its drawbacks, resulting in serious barriers to industrialization. In order to facilitate technology transfer, we critically discuss the practical feasibility of chitosan aerogels in potential applications compared to conventional and other biopolymer‐based porous or nonporous materials.

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“…Harnstoff kann entweder als chemischer Vernetzer oder, durch thermische Zersetzung, als physikalischer Koagulator wirken. [77,78] Die mechanischen Eigenschaften von feuchten Gelen und den abschließenden Aerogelen werden stark vom Grad der Vernetzung beeinflusst, der in einigen Fällen mithilfe von IR-, NMR-und/oder Ninhydrin-Analysen untersucht wurde. [35,36,79] Außerdem verdient die Ausgangslçsung sorgfältige Beachtung.D aC hitosan aus natürlichen Rohstoffen stammt, variieren Molekulargewicht und Deacetylierungsgrad stark.…”

Section: Chemische Vernetzungunclassified

Chemie der Chitosan‐Aerogele: Lenkung der dreidimensionalen Poren für maßgeschneiderte Anwendungen

et al. 2020

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Indiesem Aufsatz diskutieren wir die schnell wachsende Zahl an Literaturbeiträgen zu Chitosan-basierten porçsen Materialien, mit Schwerpunkt auf Gelierungsmechanismen, dreidimensionaler multiskaliger Strukturkontrolle sowie der mannigfaltigen chemischen Funktionalität, die mit anderen Biopolymeren nicht erreichbar ist. Die Eigenschaften unterscheiden sich von letzteren teils stark:v on überkritischg etrockneten, mesoporçsen Chitosan-Aerogelen bis hin zu äußerst leichten, gefriergetrockneten makroporçsen Gerüsten. Im Labormaßstab erreicht porçses Chitosan beeindruckende Eigenschaften, der hoch(meso)porçse Charakter verstärkt jedoch nicht nur die vorteilhafte Funktionalitätdes Chitosans,sondern auchseine Nachteile,was eine mçgliche Industrialisierung ernsthaft einschränkt. Zur Fçrderung des Technologietransfers diskutieren wir in kritischer Weise die praktische Umsetzbarkeit mçglicher Anwendungen von Chitosan-Aerogelen im Vergleich zu konventionellen und anderen biopolymerbasierten porçsen oder nichtporçsen Materialien. Aus dem Inhalt 1. Einleitung 9914 2. Synthese von Chitosan-Aerogelen 9916 3. Prozess-Struktur-Eigenschafts-Beziehungen 9920 4. Oberflächenchemie und Funktionalisierung 9925 5. Anwendungen 9927 6. Zusammenfassung und Ausblick: auf dem Wegz ur Industrialisierung 9932

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Facile preparation of biocompatible macroporous chitosan hydrogel by hydrothermal reaction of a mixture of chitosan-succinic acid-urea

Cited by 18 publications

References 36 publications

Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation

Chemistry of Chitosan Aerogels: Three‐Dimensional Pore Control for Tailored Applications

Chemie der Chitosan‐Aerogele: Lenkung der dreidimensionalen Poren für maßgeschneiderte Anwendungen

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