Facile preparation of bioactive silk fibroin/hyaluronic acid hydrogels

Yan, Shuqin; Wang, Qiusheng; Tariq, Zeeshan; You, Renchuan; Li, Xiufang; Li, Mingzhong; Zhang, Qiang

doi:10.1016/j.ijbiomac.2018.06.138

Cited by 50 publications

(36 citation statements)

References 32 publications

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“…During the process of fabricating functional silk scaffold, blending with high-molecular weight biocompatible polymers can be used to change the pore structure, porosity, microstructure, and mechanical properties; these important characteristics play a significant role in regulating the biology of grafted and resident cells (Jin et al, 2005;Lu et al, 2011). Silk has been blended with HA to mimic the ECM composition of cartilage (Jaipaew et al, 2016;Raia et al, 2017;Yan et al, 2018). The biological properties of HA are closely related to the molecular weight, and the high molecular weight HA displays superior biological and physical benefits.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair

Liu

et al. 2020

Front. Bioeng. Biotechnol.

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Interest is rapidly growing in the design and preparation of bioactive scaffolds, mimicking the biochemical composition and physical microstructure for tissue repair. In this study, a biomimetic biomaterial with nanofibrous architecture composed of silk fibroin and hyaluronic acid (HA) was prepared. Silk fibroin nanofiber was firstly assembled in water and then used as the nanostructural cue; after blending with hyaluronan (silk:HA = 10:1) and the process of freeze-drying, the resulting composite scaffolds exhibited a desirable 3D porous structure and specific nanofiber features. These scaffolds were very porous with the porosity up to 99%. The mean compressive modulus of silk-HA scaffolds with HA MW of 0.6, 1.6, and 2.6 × 106 Da was about 28.3, 30.2, and 29.8 kPa, respectively, all these values were much higher than that of pure silk scaffold (27.5 kPa). This scaffold showed good biocompatibility with bone marrow mesenchymal stem cells, and it enhanced the cellular proliferation significantly when compared with the plain silk fibroin. Collectively, the silk-hyaluronan composite scaffold with a nanofibrous structure and good biocompatibility was successfully prepared, which deserved further exploration as a biomimetic platform for mesenchymal stem cell-based therapy for tissue repair.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair

Liu

et al. 2020

Front. Bioeng. Biotechnol.

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“…The combination of silk fibroin with GAG can be a strategy to improve and modulate the brittleness of produced hydrogels [114]. Silk fibroin has been combined with GAGs, mainly HA [115][116][117], with or without other polysaccharides such as alginate [118,119] or chitosan [120], for applications in skin wound healing [116,119], vascular growth factor delivery [121] and cartilage tissue [122]. HA has been reported to improve mechanical properties of silk fibroin scaffolds partially by supporting silk fibroin transitions to β-sheet conformations [114,123], in a pH dependent complexation mechanism, and by leading to the formation of crystalline and non-crystalline phases [124].…”

Section: Silk Fibroinmentioning

confidence: 99%

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

et al. 2020

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Glycosaminoglycans (GAG) are long, linear polysaccharides that display a wide range of relevant biological roles. Particularly, in the extracellular matrix (ECM) GAG specifically interact with other biological molecules, such as growth factors, protecting them from proteolysis or inhibiting factors. Additionally, ECM GAG are partially responsible for the mechanical stability of tissues due to their capacity to retain high amounts of water, enabling hydration of the ECM and rendering it resistant to compressive forces. In this review, the use of GAG for developing hydrogel networks with improved biological activity and/or mechanical properties is discussed. Greater focus is given to strategies involving the production of hydrogels that are composed of GAG alone or in combination with other materials. Additionally, approaches used to introduce GAG-inspired features in biomaterials of different sources will also be presented.

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“…Fibroin has a molecular mass of 370 kDa and contains 18 types of amino acid such as glycine, alanine, and serine (Figure ) . Fibroin is a promising and popular biomaterial because of its outstanding thermal stability, ease of processability, mechanical superiority, tunable degradation, low inflammatory, abundance, nontoxicity, low cost, and environmental sustainability . It shows great potential applications in blood vessel engineering, medical and biological materials, drug delivery, wound dressing, porous silk scaffolds, and food and cosmetic industry .…”

Section: Introductionmentioning

confidence: 99%

Fibroin‐functionalized magnetic carbon nanotube as a green support for anchoring silver nanoparticles as a biocatalyst for A³ coupling reaction

Akbarzadeh

Koukabi

2019

Applied Organom Chemis

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Novel and powerful fibroin‐functionalized magnetic carbon nanotube–supported silver nanoparticles (CNT–Fe3O4–fibroin–Ag) were successfully synthesized as a nontoxic and inexpensive biocatalyst. The structure of the organic–inorganic hybrid bionanocomposite was characterized by various techniques such as Fourier transform infrared spectroscopy, thermogravimetric analysis, energy‐dispersive X‐ray, field emission‐scanning electron microscopy, transmission electron microscopy, X‐ray diffraction, vibrating sample magnetometry, atomic absorption spectroscopy, and inductively coupled plasma‐optical emission spectrometry. Then, the catalytic activity of synthesized bionanocomposite was evaluated in the three‐component A3 coupling reaction under solvent‐free conditions with good to excellent yields. Several propargylamine derivatives were synthesized by the reaction of different aldehydes with amines and phenylacetylene. Biodegradability, biocompatibility, availability, easy synthesis, high stability, high‐throughput, cost‐effectiveness, and efficient magnetic separation are some advantages of this catalyst that make it economically justified and sustainable. Moreover, the catalyst can be recycled for several runs without appreciable loss in its catalytic activity.

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Facile preparation of bioactive silk fibroin/hyaluronic acid hydrogels

Cited by 50 publications

References 32 publications

Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair

Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

Fibroin‐functionalized magnetic carbon nanotube as a green support for anchoring silver nanoparticles as a biocatalyst for A³ coupling reaction

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Facile preparation of bioactive silk fibroin/hyaluronic acid hydrogels

Cited by 50 publications

References 32 publications

Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair

Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair

Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks

Fibroin‐functionalized magnetic carbon nanotube as a green support for anchoring silver nanoparticles as a biocatalyst for A3 coupling reaction

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Fibroin‐functionalized magnetic carbon nanotube as a green support for anchoring silver nanoparticles as a biocatalyst for A³ coupling reaction