Facile Preparation of Anticancer Drug Encapsulated Chitosan Nanospheres and Their pH Stimulus Responsive Release Property

Jia, Ang; Yang, Tiezhu; Wan, Zhanghui; Lv, Xinyan; Zhao, Mengen; Wang, Hao; Chen, Zhenhua; Ren, Xiuli; Mei, Xifan

doi:10.1166/jbt.2016.1458

Cited by 4 publications

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“…As far as we know, capillary coated with uniform structure, controllable thickness and good anchoring, which is used for separation and enrichment targets, has rarely been reported. Chitosan (Cts), obtained by deacetylation of chitin, is a positively charged natural polysaccharide with abundant amino and hydroxyl groups under acidic condition [34] . It has been widely used in many fields including medicine, food, chemical industry, biochemical and biomedical engineering due to its excellent biodegradation, biocompatibility and non‐toxicity [35] .…”

Section: Introductionmentioning

confidence: 99%

Facile Preparation of Chitosan‐modified Mesoporous Titanium Dioxide Film on Fused‐silica Capillary for Selective Enrichment of Phosphopeptides

Jiao

Wei

et al. 2021

ChemNanoMat

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Chitosan (Cts), a positively charged natural polysaccharide, is employed to functionalize mesoporous titanium dioxide (mTiO2) nanoparticles. The prepared Cts/mTiO2 composite was used as a stationary phase to coat the inner wall of fused‐silica capillary and obtain uniform Cts/mTiO2 film. The Cts/mTiO2 film is applied to detect and enrich phosphopeptides in complex biological samples based on typical in‐tube solid phase microextraction (IT‐SPME) system. This unique Cts/mTiO2 film exhibits excellent enrichment performances of high selectivity (β‐casein and BSA in molar ratio of 1 : 1000), sensitivity (detection limit as low as 40 fmol of β‐casein tryptic digest solution) and high adsorption capacity (124.5 μg mg−1). Meanwhile, the Cts/mTiO2 film possesses preferable reusability and can be reused more than 10 times. These results confirm that the Cts/mTiO2 film possesses potential and satisfactory prospects in phosphoproteomics analysis.

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Section: Introductionmentioning

confidence: 99%