Facile preparation and characterization of pH sensitive Mt/CMC nanocomposite hydrogel beads for propranolol controlled release

Farhadnejad, Hassan; Mortazavi, Seyed Alireza; Erfan, Mohammad; Darbasizadeh, Behzad; Motasadizadeh, Hamidreza; Fatahi, Yousef

doi:10.1016/j.ijbiomac.2018.01.061

Cited by 62 publications

(21 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With further increase of pH to 7.4, the hydrogenbonding interaction of hydrogel beads disintegrated and the electrostatic repulsion of -COO − within the test hydrogel beads strengthened, which led to the further increase of the swelling ratio. The above information indicated the hydrogel beads had a benign pH-responsive behaviour with an external pH solution, which was also similar to the previous research reports in the literature [50,51].…”

Section: Swelling Properties 361 Effect Of the Pgs Content On Swellingsupporting

confidence: 91%

Preparation and application of pH-responsive composite hydrogel beads as potential delivery carrier candidates for controlled release of berberine hydrochloride

et al. 2020

View full text Add to dashboard Cite

For improving the effective concentration of berberine hydrochloride (BH) in the gastrointestinal tract, a series of pH-responsive hydrogel beads were prepared based on carboxymethylstarch-g-poly (acrylic acid)/palygorskite/starch/sodium alginate (CMS-g-PAA/PGS/ST/SA) in the present work. The developed hydrogel beads were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and thermogravimetric analysis (TG). Effect of palygorskite (PGS) content on the swelling properties of hydrogel beads and BH cumulative release were discussed. The pH responsiveness of hydrogel beads was also investigated in different media. Results illustrated that swelling of hydrogel beads and BH cumulative release from hydrogel beads were obviously affected by PGS content. The swelling ratio and BH cumulative release of composite hydrogel beads remarkably slowed down with PGS content increasing in the range from 10 to 40 wt%. The composite hydrogel beads were pH-responsive. At pH 7.4, the swelling ratio and BH cumulative release from composite hydrogel beads were the fastest among the dissolution media of pH 1.2, pH 6.8 and pH 7.4. The BH cumulative release from hydrogel beads was related to the swelling and relaxation of composite hydrogel beads and could be fitted better by the Higuchi model. The obtained composite hydrogel beads could be potentially used for the development of BH pharmaceutical dosage forms.

show abstract

Section: Swelling Properties 361 Effect Of the Pgs Content On Swellingsupporting

confidence: 91%

Preparation and application of pH-responsive composite hydrogel beads as potential delivery carrier candidates for controlled release of berberine hydrochloride

et al. 2020

View full text Add to dashboard Cite

show abstract

“…X-ray diffractometer (X ray analytical Xpert powder diffractometer) was operated and peaks in the form of diffractograms were recorded at a scanning range of 10–100° with an angle of 2θ at a rate of 3°per min. Copper k α was used as radiation source with wavelength 1.542 Å 24…”

Section: Methodsmentioning

confidence: 99%

“…Surface morphology was recorded by using SEM. JEOL Analytical Scanning Electron Microscope (JSM-6490A, JEOL, Tokyo, Japan) was operated at different magnification powers and photomicrographs were captured 24…”

Section: Methodsmentioning

confidence: 99%

<p>Development and in vitro evaluation of (β-cyclodextrin-g-methacrylic acid)/Na<sup>+</sup>-montmorillonite nanocomposite hydrogels for controlled delivery of lovastatin</p>

Mahmood¹,

A²,

Muhammad³

et al. 2019

IJN

View full text Add to dashboard Cite

Background: Hyperlipidemia is the elevation of low density lipoprotein levels resulting in fat deposites in arteries and their hardening and blockage. It is the leading cause of several life threatening pathological conditions like hypertension, cardiovascular diseases, diabetes etc. Purpose: The objective of this study was to prepare and optimize nontoxic, biocompatible β-CD-g-MAA/Na + -MMT nanocomposite hydrogels with varying content of polymer, monomer and montmorillonite. Moreover, lipid lowering potentials were determined and compared with other approaches. Methods: β-CD-g-MAA/Na + -MMT nanocomposite hydrogels (BM-1 to BM9) were prepared through free radical polymerization by using β-CD as polymer, MAA as monomer, MBA as crosslinker and montmorillonite as clay. Developed networks were evaluated for FTIR, DSC, TGA, PXRD, SEM, sol-gel fraction (%), swelling studies, antihyperlipidemic studies and toxicity studies. Results: Optimum swelling (94.24%) and release (93.16%) were obtained at higher pH values. Based on R 2 and “n” value LVT release followed zero order kinetics with Super Case II transport release mechanism, respectively. Tensile strength and elongation at break were found to be 0.0283MPa and 94.68%, respectively. Gel fraction was between 80.55 – 98.16%. Antihyperlipidemic studies revealed that LDL levels were markedly reduced from 522.24 ± 21.88mg/dl to 147.63 ± 31.5mg/dl. Toxicity studies assured the safety of developed network. Conclusion: A novel pH responsive crosslinked network containing β-CD – g – poly (methacrylic acid) polymer and MMT was developed and optimized with excellent mechanical, swelling and release properties and lipid lowering potentials.

show abstract

“…It is used with pH responsive polymers and explored for their competency in targeted drug delivery 29 , 30 . Pure polysaccharide hydrogels have very low mechanical strength and break quickly in the fluid system resulted in a burst drug delivery 31 . To enhance the mechanical strength, synthetic polymers like polyethylene glycol, polyvinyl pyrrolidone (PVP) and polyvinyl alcohol etc.…”

Section: Introductionmentioning

confidence: 99%

“…To enhance the mechanical strength, synthetic polymers like polyethylene glycol, polyvinyl pyrrolidone (PVP) and polyvinyl alcohol etc. can be added to the hydrogel blends 31 . Blending is the mixing of different polymers to achieve desirable properties 32 , 33 .…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of pH-sensitive biodegradable ternary blended hydrogel films (chitosan/guar gum/PVP) for drug delivery application

Ghauri

Islam

Qadir

et al. 2021

Sci Rep

View full text Add to dashboard Cite

AbstractpH responsive hydrogels have gained much attraction in biomedical fields. We have formulated ternary hydrogel films as a new carrier of drug. Polyelectrolyte complex of chitosan/guar gum/polyvinyl pyrrolidone cross-linked via sodium tripolyphosphate was developed by solution casting method. Fourier transform infrared spectroscopy, scanning electron microscopy and thermogravimetric analysis were conducted to examine the interactions between the polymeric chains, surface morphology and thermal stability, respectively. The swelling tests resulted that the swelling was reduced with the increase in the concentration of crosslinker due to the more entangled arrangement and less availability of pores in hydrogels. Ciprofloxacin hydrochloride was used as a model drug and its release in simulated gastric fluid, simulated intestinal fluid and phosphate buffer saline solution was studied. pH responsive behaviour of the hydrogels have subjected these hydrogels for drug release applications.

show abstract

Facile preparation and characterization of pH sensitive Mt/CMC nanocomposite hydrogel beads for propranolol controlled release

Cited by 62 publications

References 45 publications

Preparation and application of pH-responsive composite hydrogel beads as potential delivery carrier candidates for controlled release of berberine hydrochloride

Preparation and application of pH-responsive composite hydrogel beads as potential delivery carrier candidates for controlled release of berberine hydrochloride

<p>Development and in vitro evaluation of (β-cyclodextrin-g-methacrylic acid)/Na<sup>+</sup>-montmorillonite nanocomposite hydrogels for controlled delivery of lovastatin</p>

Development and evaluation of pH-sensitive biodegradable ternary blended hydrogel films (chitosan/guar gum/PVP) for drug delivery application

Contact Info

Product

Resources

About