Facile pathway to construct mesoporous silica nanoparticles loaded with pyraclostrobin: Physicochemical properties, antifungal activity, and biosafety

Abstract

BACKGROUND A controlled‐release formulation based on mesoporous silica nanoparticles (MSNs) provides an effective way for reducing pesticide use and protecting the ecological environment. In this study, MSNs loaded with pyraclostrobin (PYR@MSNs) were prepared using a one‐pot method. RESULTS The characteristics of PYR@MSNs were systematically investigated, including morphology, loading content, ultraviolet (UV) resistance, release behavior, control effects against pathogens, and safety to nontarget organisms. The results show that the prepared PYR@MSNs presented characteristics of regular spherical shapes, uniform particle size (200 nm), high drug loading (38.9%), and enhanced UV resistance. Compared with traditional formulation, PYR@MSNs exhibited improved control effects against Fusarium graminearum, an extended control period, and lower toxicity to zebrafish, earthworms and BEAS‐2B cells. CONCLUSIONS This research will facilitate the development of efficient and safe pesticide delivery systems. The PYR@MSNs has showed its potential as a new controlled‐release formulation with increased efficacy and is expected to benefit the sustainable development of agriculture. © 2022 Society of Chemical Industry.

Nanobiopesticides in sustainable agriculture: developments, challenges, and perspectives

“…129 Nanotechnology can offer ecofriendly and green alternatives for plant disease control, and the use of nanotechnology to develop safe antifungal agents is of great significance. [129][130][131][132][133][134] Nanobiofungicides are fungicides formulated at the nanometer size with novel properties and can be designated as nanohybrids or nanocomposites. 135,136 It has been reported that microorganisms (including bacteria, fungi, actinomyces, yeast, and algae) and plants are able to synthesize nanofungicides, [137][138][139] and the biosynthesis of nanofungicides has been recognized as an efficient and green method.…”

Porous Silica Nanocarriers: Advances in Structural Orientation and Modification to Develop Sustainable Pesticide Delivery Systems

“…Similar results of lower toxicity from PSNdelivered pesticide on earthworms were also found on several other studies. 82,83 Further, several studies reported reduced phytotoxicity of PSN-delivered pesticides in terms of chromosome aberration (CA) and mitotic index (MI), where a lower CA and higher MI indicate safer molecules. The Vicia faba chromosomal aberration indexes of lambda cyhalothrin EC were 0.21, 0.25, and 0.31 at concentrations of 10, 50, and 100 mg/L, whereas those of dopamine-conjugated MSN-encapsulated lambda cyhalothrin were 0.04, 0.05, and 0.06, respectively, at the same concentration.…”

“…Several studies have also reported lower apoptosis rates of PSN-delivered pesticides compared to conventional formulations. 82,83 Thus, the sustained cell viability with lower apoptosis rate demonstrates that PSNs are a safer nanocarrier for both pesticide applicators and neighbors.…”

“…However, the loading capacity can also be improved by using presynthesis loading techniques. ,,,, For instance, Feng and co-workers loaded prothioconazole into MSNs using a preloading technique, resulting in a 38.8% loading content. This process requires less time, but maintaining porous structure and particle size in nanoscale is sometimes difficult.…”

Construction and biological effects of a redox‐enzyme dual‐responsive lufenuron nano‐controlled release formulation

“…The cells were allowed to stain at 4 °C for 15 min in the dark. [57][58][59] 3 RESULTS AND DISCUSSION…”