Facile One‐pot Synthesis of Arylsulfonyl‐4H‐pyrans Catalyzed by Ru Loaded Fluorapatite

Abstract

We report a novel ecofriendly cascade reaction for the synthesis of arylsulfonyl-4H-pyran derivatives by a three component fusion reaction of chosen aldehyde, dimedone and phenylsulphonyl acetonitrile at room temperature using ruthenia doped fluorapatite (RuO 2 /FAp) as recyclable catalyst. Different percentages of RuO 2 /FAp materials were prepared and characterized by FT-IR, P-XRD, BET, SEM-EDX and TEM analysis. Attractive features of the synthetic approach are operational simplicity, cost-effectiveness, short reaction time and excellent yields. Easily recoverable and reusable catalyst material without any deceptive loss of catalytic activity up to seven cycles is additional benefit.

Advances in Pyranopyrazole Scaffolds’ Syntheses Using Sustainable Catalysts—A Review

“…Shaterian and co-workers [61] developed titanium dioxide as a nanocatalyst for the generation of dihydropyrano-[2,3-c]-pyrazoles (13) through a one-step process. The condensation was carried under solvent-free conditions at RT by reacting the substituted aldehydes (10), malononitrile (3), hydrazine hydrate (11) and ethyl acetoacetate (12). Additionally, 0.25 mmol of nano-titania showed excellent product yields (81-96%) (Scheme 3).…”

“…Diverse conceptualisations have proven helpful in interpreting activity associated with different heterogeneous catalysts. In supported catalyst materials, the active phase experience phase-support associations [ 11 ]. The surface free dynamics of the active phase, with catalytic support materials and the interfacial free energy between the two constituents, help such interactions.…”

“…Additionally, easy recovery and recyclability (compared to homogeneous catalysts) sustained interest in them [8][9][10]. The tunable strong acid and base properties and catalytic activity of heterogeneous materials played a crucial role in organic synthesis [10][11][12]. Generally, it is challenging to design and develop eco-friendly, costeffective and stable composites that show good activity.…”

“…The surface free dynamics of the active phase, with catalytic support materials and the interfacial free energy between the two constituents, help such interactions. Transition metal oxides possess considerably low surface free energies, similar to support materials like alumina, titania, zirconia, and silica [9][10][11][12]. The active transition metal oxide develops a monolayer through the wetting of the support surface.…”

A Facile and Catalyst-Free Microwave-Promoted Multicomponent Reaction for the Synthesis of Functionalised 1,4-Dihydropyridines With Superb Selectivity and Yields

“…The one-pot processes afford a high atom economy, high functional group tolerance, avoidance of the separation and purification methods, and minimizing the chemical waste (Kerru et al, 2020c , d ). Thus, the MCR strategy is an economical approach for the synthesis of libraries of heterocyclic molecules for medicinal chemistry benefits (Maddila et al, 2020a ).…”