Facile one-pot synthesis of 2-oxazoline

Poly(2‐oxazoline)s: a comprehensive overview of polymer structures and their physical properties—an update

“…40 Very recently, Liu and colleagues developed a weak organic base 4-dimethylaminopyridine (DMAP) catalysed facile one-pot synthesis of differently substituted 2-oxazoline monomers with high yield from easily accessible carboxylic acids and 2-chloroethyl isocyanate. 41 The CROP mechanism for the polymerization of 2-oxazoline monomers follows three common steps: 'initiation' via electrophilic addition, 'propagation' via nucleophilic substitution and 'termination' through externally added nucleophiles (Fig. 1).…”

“…Other (less known) synthetic pathways are also available for the synthesis of (complex) 2‐oxazoline monomers such as α‐deprotonation of MeOx followed by alkylation 40 . Very recently, Liu and colleagues developed a weak organic base 4‐dimethylaminopyridine (DMAP) catalysed facile one‐pot synthesis of differently substituted 2‐oxazoline monomers with high yield from easily accessible carboxylic acids and 2‐chloroethyl isocyanate 41 …”

“…A facile one‐pot synthesis approach has been introduced recently by Liu and colleagues to prepare diverse functional 2‐oxazoline monomers from easily accessible carboxylic acids and 2‐chloroethyl isocyanate 41 (Fig. 4).…”

“…(A), and chemical structures of 2‐oxazoline monomers synthesized by following the approach (B). Reproduced from reference 41 with permission from Elsevier.…”