Facile, One-Pot Synthesis, and Antibacterial Activity of Mesoporous Silica Nanoparticles Decorated with Well-Dispersed Silver Nanoparticles

Abstract

In this study, we exploit a facile, one-pot method to prepare MCM-41 type mesoporous silica nanoparticles decorated with silver nanoparticles (Ag-MSNs). Silver nanoparticles with diameter of 2-10 nm are highly dispersed in the framework of mesoporous silica nanoparticles. These Ag-MSNs possess an enhanced antibacterial effect against both Gram-positive and Gram-negative bacteria by preventing the aggregation of silver nanoparticles and continuously releasing silver ions for one month. The cytotoxicity assay indicates that the effective antibacterial concentration of Ag-MSNs shows little effect on human cells. This report describes an efficient and economical route to synthesize mesoporous silica nanoparticles with uniform silver nanoparticles, and these nanoparticles show promising applications as antibiotics.

Antibiotic-loaded, silver core-embedded mesoporous silica nanovehicles as a synergistic antibacterial agent for the treatment of drug-resistant infections

“…This is of particular relevance to the released Ag þ , as they are well known for their high affinity with thiol groups of proteins [47]. In addition, the biocompatible mesoporous silica coating should be regarded as another account for the biosafety of Ag@MSNs@LEVO, which has been proven in a previous report [24]. Even though the nanoplatform of Ag@MSNs@LEVO exhibits an excellent biocompatibility in the short term evaluation, the potential risks of long term toxicity still need to be carefully investigated in the future.…”

Aminopropyl-modified mesoporous molecular sieves as efficient adsorbents for removal of auxins

“…According to the IUPAC nomenclature mesoporous structures are characterized by the pore size from 2 to 50 nm [2]. Particularly, mesoporous silica materials have been extensively studied due to their applications in catalysis [3], sorption and separation processes [4], enzyme immobilization [5], sensor design [6], energy storage [7], antimicrobial carriers [8], and drug delivery [9] among others. Mesoporous silicas have gathered a significant attention in diverse fields of applications for their high chemical stability, large pore volume, high specific surface area and possibility of surface modification [10].…”

Synergistic bactericidal activity of chlorhexidine-loaded, silver-decorated mesoporous silica nanoparticles

“…[22][23][24][25][26][27] Conventionally, silver NPs are immobilized onto or embedded into MSNs to avoid the aggregation of silver NPs. 28,29 Thus, these nanocarriers slowly release silver ions, leading to enhanced efficacy against bacteria. 30,31 In addition, MSNs with entrapped CHX can exhibit sustainable CHX release behavior and inhibit bacterial growth while maintaining their surface integrity.…”