Facile, Large-Quantity Synthesis of Stable, Tunable-Color Silicon Nanoparticles and Their Application for Long-Term Cellular Imaging

Zhong, Yiling; Sun, Xiaotian; Wang, Siyi; Peng, Fei; Bao, Feng; Su, Yuanyuan; Li, Youyong; Lee, Shuit‐Tong; He, Yao

doi:10.1021/acsnano.5b00683

Cited by 210 publications

(163 citation statements)

References 73 publications

(175 reference statements)

Supporting

Mentioning

156

Contrasting

Order By: Relevance

“…However, for application in biological systems, SiQDs must be water-soluble. Based on this evidence, several methods for the aqueous synthesis of silicon quantum dots have been described in the literature [3,4,18,19,20]. Despite the intense efforts to construct numerous drug nanocarriers for tumor-target drug delivery, knowledge about the toxic, pharmacokinetic, and pharmacodynamic effects of these nanomaterials is still lacking [21].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines

et al. 2018

View full text Add to dashboard Cite

Luminescent mesoporous silica nanoparticles, CdTeQDs@MNs@PEG1, SiQDs@Isoc@MNs and SiQDs@Isoc@MNs@PEG2, were successfully synthetized and characterized by SEM, TEM, XRD, N2 nitrogen isotherms, 1H NMR, IR, absorption, and emission spectroscopy. Cytotoxic evaluation of these nanoparticles was performed in relevant in vitro cell models, such as human hepatoma HepG2, human brain endothelial (hCMEC/D3), and human epithelial colorectal adenocarcinoma (Caco-2) cell lines. None of the tested nanoparticles showed significant cytotoxicity in any of the three performed assays (MTT/NR/ LDH) compared with the respective solvent and/or coating controls, excepting for CdTeQDs@MNs@PEG1 nanoparticles, where significant toxicity was noticed in hCMEC/D3 cells. The results presented reveal that SiQDs-based mesoporous silica nanoparticles are promising nanoplatforms for cancer treatment, with a pH-responsive drug release profile and the ability to load 80% of doxorubicin.

show abstract

Section: Introductionmentioning

confidence: 99%

Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines

et al. 2018

View full text Add to dashboard Cite

show abstract

“…[ 14,15 ] This is largely due to the nontoxicity and abundance of Si and the compatibility of Si-NC technology with well-established bulkSi technology. Analogous to bulk Si, signifi cant efforts have been devoted to doping Si NCs to realize the full potential of Si NCs.…”

Section: Introductionmentioning

confidence: 99%

Size‐Dependent Structures and Optical Absorption of Boron‐Hyperdoped Silicon Nanocrystals

Zhou

et al. 2016

Advanced Optical Materials

View full text Add to dashboard Cite

and intermediate-band transition for bulk Si. [ 19,20 ] For Si NCs, hyperdoping is also emerging as an effective means to obtain novel properties. [21][22][23][24][25][26] For instance, localized surface plasmon resonance (LSPR) may occur to hyperdoped Si NCs. [21][22][23] And the energy of the LSPR can be conveniently tuned by the doping level.It is well known that the properties of intrinsic Si NCs are critically dependent on the NC size. [ 27,28 ] However, the size effect for hyperdoped Si NCs has been hardly explored. Previous work simply focused on the effect of the doping level. It has been recently predicted that the LSPR of hyperdoped Si NCs can be controlled by not only the doping level but also the NC size. [ 29 ] This highlights that the critical role played by the size effect may remain for Si NCs after hyperdoping. Therefore, it is of great interest to also investigate the size effect for hyperdoped Si NCs. Knowledge concerning the effect of the NC size on the dependence of the properties of hyperdoped Si NCs on the doping level should be invaluable for the synthesis of hyperdoped Si NCs with desired functionality.In this work, Si NCs hyperdoped with different B-doping levels are considered. The dependence of the physical properties of hyperdoped Si NCs on the NC size is examined. It is shown that the largest Si NCs undergo a stronger reduction of the average lattice spacing upon doping with respect to the smallest ones. While Raman, subbandgap optical absorption and the LSPR spectra are all modifi ed with increasing B concentrations in Si NCs, they also indicate that the largest Si NCs are less affected by disorder and charge carrier surface scattering. As a result, there exists a range of doping concentrations where the LSPR energy can be blueshifted as the NC size decreases. Results and DiscussionBoth B-hyperdoped and undoped Si NCs with different sizes have been synthesized by using SiH 4 -based nonthermal plasma. [ 6,[30][31][32] The atomic concentrations of B in B-hyperdoped Si NCs are ≈17%, 36%, and 60%, which are measured with inductively coupled plasma-atomic emission spectroscopy (ICP-AES). Transmission electron microscopy (TEM) and Raman

show abstract

“…Silicon nanocrystals (Si NCs) have been intensively investigated during past decades for their promising applications in various fields such as optoelectronics [1][2][3][4][5][6], photovoltaics [7][8][9][10][11], energy storage [12,13], and bioimaging [14,15]. This is mainly due to their nontoxicity, low cost, and compatibility with well-established Si-based microelectronic technology.…”

Section: Introductionmentioning

confidence: 99%

Density functional theory study on the B doping and B/P codoping of Si nanocrystals embedded in SiO2

Cottenier

et al. 2017

Phys. Rev. B

View full text Add to dashboard Cite

Doping silicon nanocrystals (Si NCs) embedded in silicon dioxide (SiO 2 ) with boron (B) and phosphorus (P) is a promising way of tuning the properties of Si NCs. Here we take advantage of density functional theory to investigate the dependence of the structural and electronic properties of Si NCs embedded in SiO 2 on the doping of B and P. The locations and energy-level schemes are examined for singularly B-doped or B/P-codoped Si NCs embedded in SiO 2 with a perfect or defective Si/SiO 2 interface at which a Si dangling bond exists. A dangling bond plays an important role in the doping of Si NCs with B or B/P. The doping behavior of B in Si NCs embedded in SiO 2 vastly differs from that of P. The electronic structure of a B/P-codoped Si NC largely depends on the distribution of the dopants in the NC.

show abstract

Facile, Large-Quantity Synthesis of Stable, Tunable-Color Silicon Nanoparticles and Their Application for Long-Term Cellular Imaging

Cited by 210 publications

References 73 publications

Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines

Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines

Size‐Dependent Structures and Optical Absorption of Boron‐Hyperdoped Silicon Nanocrystals

Density functional theory study on the B doping and B/P codoping of Si nanocrystals embedded in SiO2

Contact Info

Product

Resources

About