Facile Ionic Liquid–Mediated Protocol for the Regioselective Synthesis of 1,5-Benzothiazepines

Green Synthetic Approaches for Medium Ring-Sized Heterocycles of Biological Interest

“…Recently, an efficient one-step IL-mediated green protocol for the regioselective synthesis of stereoisomeric 2-aryl-3-hydroxy-1,5-benzothiazepines-4-ones (Scheme 25) from the reaction of 2-aminothiophenol with glycidates has been reported [86]. Recently, an efficient one-step IL-mediated green protocol for the regioselective synthesis of stereoisomeric 2-aryl-3-hydroxy-1,5-benzothiazepines-4-ones (Scheme 25) from the reaction of 2-aminothiophenol with glycidates has been reported [86].…”

Triton B promoted highly regio- and chemoselective ring opening of epoxides with 2-aminobenzenethiol under solvent-free conditions

“…1, 2-Amino thiols are structural units of undoubted synthetic interest in organic chemistry 24 because they contain both an amine function and a thiol group. The cleavage of epoxides with amino thiols is interesting since the resultant amino hydroxysulfides are important for the synthesis of many biologically interesting molecules 25 and heterocycles such as benzothiazepines 26 .…”