Facile hydrothermal synthesis of NiTe nanorods for non-enzymatic electrochemical sensing of whole blood hemoglobin in pregnant anemic women

Fatima, Batool; Saeed, Ummama; Hussain, Dilshad; Jawad, Shan-e-Zahra; Rafiq, Hafiza Sana; Majeed, Saadat; Manzoor, Sumaira; Qadir, Saima Yasmin; Ashiq, Muhammad Naeem; Najam‐ul‐Haq, Muhammad

doi:10.1016/j.aca.2021.339204

Cited by 9 publications

(8 citation statements)

References 39 publications

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“…In addition, electrochemical determination with screen-printed electrodes (SPEs) has been a widespread utilization in clinical and biomedical areas for the detection of biological molecules (proteins/peptides, DNA, amino acids, and various metabolites) to diagnose or prognose diseases. These electrodes have easy modification techniques, including quickness, disposability, affordability, robustness, trace volume consumption, higher reproducibility, and decreased pretreatment requirements for samples, which would be encouraging to detect biological molecules in complex matrices [34].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of GO/ZIF-67 Nanocomposite: Investigation of Catalytic Activity for the Determination of Epinine in the Presence of Dobutamine

et al. 2022

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In this study, we prepared graphene oxide (GO)/ZIF-67 nanocomposites. Therefore, GO/ZIF-67 nanocomposites were used as a modifier on a screen-printed electrode (GO/ZIF-67/SPE) for studying the electrochemical behavior of epinine in phosphate buffer saline (PBS) at pH 7.0 with voltammetry techniques. The GO/ZIF-67/SPE showed greater electrocatalytic activities than the bare SPE. As a result, the GO/ZIF-67/SPE was utilized for additional electrochemical examinations. The epinine concentration determination was in the range 9.0 × 10−8 M to 5.0 × 10−4 M, and the limit of detection (LOD) as well as the limit of quantification (LOQ) equaled 2.0 and 6.6 nM, respectively. From the scan rate study, the oxidation of epinine was found to be diffusion-controlled, and the simultaneous detection of epinine and dobutamine were well achieved with the differential pulse voltammetric (DPV) technique. Moreover, the stability and reproducibility of epinine at the GO/ZIF-67/SPE was studied, and the use of the GO/ZIF-67/SPE to detect epinine and dobutamine in real samples was furthermore successfully demonstrated.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of GO/ZIF-67 Nanocomposite: Investigation of Catalytic Activity for the Determination of Epinine in the Presence of Dobutamine

et al. 2022

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“…Hemoglobin in anemic pregnant women was quantified in a study using the development of NiTe nanorods-based non-enzymatic sensors and demonstrated the use of the nanorods in an electrochemical analysis of hemoglobin in thalassemic patients [ 95 ]. Dolak et al successfully synthesized a molecularly imprinted cryogel based on lanthanide-chelate, in accordance with the cryopolymerization techniques, for the selective separation of hemoglobin from serum, demonstrating a 94.34% recovery, thus, could successfully be used in the diagnosis of thalassemia [ 96 ].…”

Section: Nanobiosensor For the Diagnosis Of Thalassemiamentioning

confidence: 99%

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Tariq

Qadeer²,

Anjum

et al. 2023

Biosensors

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Thalassemia is a monogenic autosomal recessive disorder caused by mutations, which lead to abnormal or reduced production of hemoglobin. Ineffective erythropoiesis, hemolysis, hepcidin suppression, and iron overload are common manifestations that vary according to genotypes and dictate, which diagnosis and therapeutic modalities, including transfusion therapy, iron chelation therapy, HbF induction, gene therapy, and editing, are performed. These conventional therapeutic methods have proven to be effective, yet have several disadvantages, specifically iron toxicity, associated with them; therefore, there are demands for advanced therapeutic methods. Nanotechnology-based applications, such as the use of nanoparticles and nanomedicines for theragnostic purposes have emerged that are simple, convenient, and cost-effective methods. The therapeutic potential of various nanoparticles has been explored by developing artificial hemoglobin, nano-based iron chelating agents, and nanocarriers for globin gene editing by CRISPR/Cas9. Au, Ag, carbon, graphene, silicon, porous nanoparticles, dendrimers, hydrogels, quantum dots, etc., have been used in electrochemical biosensors development for diagnosis of thalassemia, quantification of hemoglobin in these patients, and analysis of conventional iron chelating agents. This review summarizes the potential of nanotechnology in the development of various theragnostic approaches to determine thalassemia-causing gene mutations using various nano-based biosensors along with the employment of efficacious nano-based therapeutic procedures, in contrast to conventional therapies.

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“…Chronoamperometry was used to assess the response of the biosensor toward HbA1c; the sensor response was linear in 0.01−1.0 mg/mL range, with a sensitivity of 0.09 μA mm −2 μg −1 mL. A non-enzymatic sensor was prepared by the deposition of NiTe on a glassy carbon electrode (NiTe/GCE), where the electrode is found to be sensitive for Hb anemic pregnant women using cyclic voltammetry (CV) in the 0.025− 0.90 nM range with a limit of detection (LOD) of 0.012 nM, a limit of quantitation (LOQ) of 0.040 nM, and a stability of 12 h. 22 In this study, a simple and cheap method for the determination of Hb is developed. Our knowledge of Hb detection is largely based on iron coordinated with porphyrin; many electrochemical studies of Hb detection are based on the fouling of Hb on the surface of the electrode; therefore, the signal obtained gets always lower with higher spikes of Hb.…”

Section: Introductionmentioning

confidence: 99%

“…Chronoamperometry was used to assess the response of the biosensor toward HbA1c; the sensor response was linear in 0.01–1.0 mg/mL range, with a sensitivity of 0.09 μA mm –2 μg –1 mL. A non-enzymatic sensor was prepared by the deposition of NiTe on a glassy carbon electrode (NiTe/GCE), where the electrode is found to be sensitive for Hb anemic pregnant women using cyclic voltammetry (CV) in the 0.025–0.90 nM range with a limit of detection (LOD) of 0.012 nM, a limit of quantitation (LOQ) of 0.040 nM, and a stability of 12 h. 22 …”

Section: Introductionmentioning

confidence: 99%

Modified Graphite Pencil Electrode Based on Graphene Oxide-Modified Fe₃O₄ for Ferrocene-Mediated Electrochemical Detection of Hemoglobin

et al. 2023

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This study describes the synthesis of graphene oxide-modified magnetite (rGO/Fe3O4) and its use as an electrochemical sensor for the quantitative detection of hemoglobin (Hb). rGO is characterized by a 2θ peak at 10.03° in its X-ray diffraction, 1353 and 1586 cm–1 vibrations in Raman spectroscopy, while scanning electron microscopy coupled with energy-dispersive spectroscopy of rGO and rGO/Fe3O4 revealed the presence of microplate structures in both materials and high presence of iron in rGO/Fe3O4 with 50 wt %. The modified graphite pencil electrode, GPE/rGO/Fe3O4, is characterized using cyclic voltammetry. Higher electrochemical surface area is obtained when the GPE is modified with rGO/Fe3O4. Linear scan voltammetry is used to quantify Hb at the surface of the sensor using ferrocene (FC) as an electrochemical amplifier. Linear response for Hb is obtained in the 0.1–1.8 μM range with a regression coefficient of 0.995, a lower limit of detection of 0.090 μM, and a limit of quantitation of 0.28 μM. The sensor was free from interferents and successfully used to sense Hb in human urine. Due to the above-stated qualities, the GPE/rGO/Fe3O4 electrode could be a potential competitive sensor for trace quantities of Hb in physiological media.

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Facile hydrothermal synthesis of NiTe nanorods for non-enzymatic electrochemical sensing of whole blood hemoglobin in pregnant anemic women

Cited by 9 publications

References 39 publications

Synthesis and Characterization of GO/ZIF-67 Nanocomposite: Investigation of Catalytic Activity for the Determination of Epinine in the Presence of Dobutamine

Synthesis and Characterization of GO/ZIF-67 Nanocomposite: Investigation of Catalytic Activity for the Determination of Epinine in the Presence of Dobutamine

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Modified Graphite Pencil Electrode Based on Graphene Oxide-Modified Fe₃O₄ for Ferrocene-Mediated Electrochemical Detection of Hemoglobin

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Facile hydrothermal synthesis of NiTe nanorods for non-enzymatic electrochemical sensing of whole blood hemoglobin in pregnant anemic women

Cited by 9 publications

References 39 publications

Synthesis and Characterization of GO/ZIF-67 Nanocomposite: Investigation of Catalytic Activity for the Determination of Epinine in the Presence of Dobutamine

Synthesis and Characterization of GO/ZIF-67 Nanocomposite: Investigation of Catalytic Activity for the Determination of Epinine in the Presence of Dobutamine

Thalassemia and Nanotheragnostics: Advanced Approaches for Diagnosis and Treatment

Modified Graphite Pencil Electrode Based on Graphene Oxide-Modified Fe3O4 for Ferrocene-Mediated Electrochemical Detection of Hemoglobin

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Product

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Modified Graphite Pencil Electrode Based on Graphene Oxide-Modified Fe₃O₄ for Ferrocene-Mediated Electrochemical Detection of Hemoglobin