Facile Functionalization of Polymer Surfaces in Aqueous and Polar Organic Solvents via 3-Mercaptopropylsilatrane

Tseng, Yen Ta; Lu, Hsin Yu; Li, Jie Ren; Tung, Wan Ju; Chen, Wen Hao; Chau, Lai-Kwan

doi:10.1021/acsami.6b13926

Cited by 25 publications

(19 citation statements)

References 56 publications

(138 reference statements)

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“…Furthermore, research also focuses on the functionalization of macromolecules (Tseng et al, 2016; Cao et al, 2018; Wu et al, 2018). Although methods for macromolecule modification are numerous, a flexible, moderate, and a reliable reaction is still an effective and efficient method of polymer modification.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, Investigation, and Application of a Macromolecule Photoswitch

et al. 2019

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Azobenzene (AZO) has attracted increasing interest due to its reversible structural change upon a light stimulus. However, poor fatigue durability and the photobleaching phenomenon restricts its further application. Herein, the AZO domain as a pendent group, was incorporated into copolymers, which was synthesized by radical copolymerization in the research. Structure-properties of synthesized copolymer can be adjusted by monomer ratios. Emphatically, responsive properties of copolymer in different solutions were investigated. In the DMSO solution, copolymer exhibited effective structural change, stable rapid responsive time (1 min) upon UV light at room temperature, stable relative acceptable recovery time (100 min) upon white light at room temperature, and good fatigue resistance property. In an aqueous solution, even more controllable responsive properties and fatigue resistance properties for copolymer were verified by results. More pervasively, the recovery process could be controlled by light density and temperature. In order to clarify reasons for the difference between the AZO molecule and the AZO domain of copolymer, energy barrier or interactions between single atoms or even structural units was calculated using the density functional theory (DFT). Furthermore, the status of copolymer was characterized by dynamic light scattering (DLS) and transmission electron microscope (TEM). Finally, copolymer was further functionalized with bioactive protein (concanavalin, ConA) to reduce the cytotoxicity of the AZO molecule.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis, Investigation, and Application of a Macromolecule Photoswitch

et al. 2019

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“…The ubiquitous linker 11‐mercaptoundecanoic acid can grab the noble metal surface through a sulfur bond and immobilize the amino groups of biomolecules via the EDC/NHS system (EDC represents 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide hydrochloride and NHS represents N‐hydroxysuccinimide) . Another molecule, 3‐mercaptopropylsilatrane, can also serve as a linker at the interface between polymer and metallic surfaces …”

Section: Principle and Fabrication Of Lspr Biosensorsmentioning

confidence: 99%

Construction of Plasmonic Nano‐Biosensor‐Based Devices for Point‐of‐Care Testing

Wang

Zhou

2017

Small Methods

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rapid detection technique for the future of home healthcare, mobile healthcare, and public health security. [4] At present, POCTs mainly use conventional lateral flow assays (LFAs) and electrochemical biosensors (such as blood glucose meter) for biosensing. [4,5] To promote the wider application of POCT, new sensing components are expected to appear. Plasmonic nano-biosensor, which stems from the interaction of light and metal nanostructures, is an advancing and promising optical sensor for ultrasensitive, ultrahighspatial-resolution and label-free biodetection. Plasmonic biosensors are mainly divided into propagating surface plasmon resonance (PSPR) and localized surface plasmon resonance (LSPR) biosensors. PSPR arises from the interaction between incident light and a planar metal surface; LSPR confines light to metal nanostructures that are smaller than the wavelength of light, thereby enabling the measurement of the dielectric changes near the metallic surface. [6] Compared with commercially available PSPR sensors, LSPR sensors are simple, cost effective, easy to integrate into miniaturized devices, and suitable for measuring changes in local refractive index (RI) caused by the adsorption of target molecules. [4] Since RI is related to the dielectric property of the environment near the metal nanostructures, LSPR sensors can realize RI biosensing in a convenient way. LSPR nano-biosensors are expected to be easily integrated into miniaturized devices for POCT. Due to the high sensitivity of LSPR biosensor and its possibility to achieve full automation, as therefore to attain time-saving and avoid human error, the integration of LSPR biosensors into portable devices will promote the wider applications of POCT for enhanced healthcare (e.g., on-site diagnosis, personalized medicine, wearable devices, etc.), higher public security (e.g., antiterrorism), environmental monitoring, and food safety. [7][8][9] The evolving of LSPR biosensing into POCT mainly involves four core requirements (Figure 1): i) sensing nanosubstrates with high RI sensitivity; ii) detection strategies to realize specific detection; iii) integrated microfluidic chips for sample pretreatment and multiplex analysis, and iv) portable POCT devices to perform automated and easy-to-use biodetections. Through the advances on plasmonics and nanofabrication in the last few years, highly sensitive as well as large-area producible nanosubstrates for LSPR biosensing have been developed. [10][11][12] In the meanwhile, high specificity and strong anti-interference Next-generation healthcare equipment and devices are in great demand for point-of-care testing (POCT), in view of their applications in rapid disease diagnosis, personalized medicine, portable or mobile health care, nontechnician assays, etc. Localized surface plasmon resonance (LSPR) biosensors, which are based on noble-metal nanostructures and which provide fast, realtime, nonlabeled, and sensitive biochemical detections, have become one of the leading candidates for POCT. The advances in nanofabr...

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“…It has been shown that silatrane coatings, in contrast to alkoxysilane ones, ensure a more facile formation of thin and uniform films, as well as better molecular regularity and availability of the functional groups on the various surfaces (glass, mica, paper, cotton, natural and synthetic polymers, silica gels, metal oxides) (see Refs. [ 24 , 25 , 26 , 27 , 28 ] and literature cited therein).…”

Section: Introductionmentioning

confidence: 99%

3-Aminopropylsilatrane and Its Derivatives: A Variety of Applications

et al. 2022

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Silatranes arouse much research interest owing to their unique structure, unusual physical–chemical properties, and diverse biological activity. The application of some silatranes and their analogues has been discussed in several works. Meanwhile, a comprehensive review of the wide practical usage of silatranes is still absent in the literature. The ability of silatranes to mildly control hydrolysis allows them to form extremely stable and smooth siloxane monolayers almost on any surface. The high physiological activity of silatranes makes them prospective drug candidates. In the present review, based on the results of numerous previous studies, using the commercially available 3-aminopropylsilatrane and its hybrid derivatives, we have demonstrated the high potential of 1-organylsilatranes in various fields, including chemistry, biology, pharmaceuticals, medicine, agriculture, and industry. For example, these compounds can be employed as plant growth biostimulants, drugs, optical, catalytic, sorption, and special polymeric materials, as well as modern high-tech devices.

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Facile Functionalization of Polymer Surfaces in Aqueous and Polar Organic Solvents via 3-Mercaptopropylsilatrane

Cited by 25 publications

References 56 publications

Design, Synthesis, Investigation, and Application of a Macromolecule Photoswitch

Design, Synthesis, Investigation, and Application of a Macromolecule Photoswitch

Construction of Plasmonic Nano‐Biosensor‐Based Devices for Point‐of‐Care Testing

3-Aminopropylsilatrane and Its Derivatives: A Variety of Applications

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