Facile Fabrication of Stimuli‐Responsive Polymer Capsules with Gated Pores and Tunable Shell Thickness and Composite

Lin, Changxu; Wang, Zhu; Yang, Haowei; An, Qi; Tao, Cheng‐an; Li, Weina; Cui, Jiecheng; Li, Zilu; Li, Guangtao

doi:10.1002/anie.201007747

Cited by 29 publications

(16 citation statements)

References 45 publications

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“…Hollow nanoparticles or nanocapsules 1,2 are emerging as one of the most promising tools in medical biotechnology for a variety of therapeutic applications, such as target drug delivery for treating cancer or tumour cells, [3][4][5][6][7][8] gene delivery and in molecular bio-imaging. [9][10][11] To date, an enormous research effort has been devoted to the search for suitable materials and methods to achieve hollow nanocapsules based on polymers, 3,5,6 liposomes, 12 inorganic metals [13][14][15] and oxides, 4 with specific surface properties, as these are very important for their therapeutic applications, otherwise drug-loaded capsules can fall off the target tissues, due to cell turnover. 16,17 Selective etching based on structural differences has also been employed to produce hollow inorganic and mesoporous coreshell nanocapsules.…”

Section: Introductionmentioning

confidence: 99%

CPMV-induced synthesis of hollow mesoporous SiO₂nanocapsules with excellent performance in drug delivery

et al. 2015

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Hollow mesoporous-SiO2 nanocapsules have been synthesized at room temperature using unmodified cowpea Mosaic Virus (CPMV) as a template, and without using any catalyst or surfactant during the synthesis. The average size of the capsules synthesized was ∼200-250 nm with a 60-100 nm hollow core. The resulting nanocapsules were characterized using high resolution transmission electron microscopy (HRTEM). The biocompatibility of the hollow mesoporous SiO2 nanocapsules was investigated with an MTT assay using the RAW 264.7 cells, HepG2 cells (human liver carcinoma cells), and Hek293 cells (human embryonic kidney cells). The nanocapsules were loaded with fluorescent molecules (rhodamine 6G), doxorubicin (DOX) – an anticancer drug, and chloroquine diphosphate (CQDP) – an antimalarial drug, and their release was studied using a UV-Vis spectrometer. The development of surfactant free, bio-safe, hollow and mesoporous SiO2 nanocapsules with CPMV provides a route for the synthesis of porous nanocapsules for drug loading and the sustained delivery of drugs. The synthesis method for hollow mesoporous SiO2 nanocapsules using CPMV is novel, straightforward, and further demonstrates that, in general, nanoformulated capsules can be used for various drug-delivery-based therapeutic applications. To check the in vitro efficacy in medical biotechnology, Hek293 and HepG2 cell lines were used to study the cell viability of DOX-loaded hollow silica nanocapsules. The results show that the bio SiO2 nanocapsules synthesized with CPMV present an effective cargo and are suitable for nanoformulating with DOX, with the resultant nanoformulation showing good promise for killing cancer specific cells.

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Section: Introductionmentioning

confidence: 99%

CPMV-induced synthesis of hollow mesoporous SiO₂nanocapsules with excellent performance in drug delivery

et al. 2015

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“…The most commonly used method for preparing hollow polymer particles requires layer-by-layer polymer shell assembly and a colloidal template. 10,15,16 Other approaches to preparing hollow polymer particles involve in situ polymerisation, 17,18 solid stabilised emulsions, 19 or coacervation. 20 Recently, calcium carbonate has been used as a colloidal template.…”

Section: Introductionmentioning

confidence: 99%

Tuning the properties of pH-responsive and redox sensitive hollow particles and gels using copolymer composition

2012

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Biodegradable pH-responsive hollow polymer particles offer excellent potential for preparing high performance biomaterials. Unfortunately, the established methods for pH-responsive hollow particle preparation are laborious and difficult to scale up. Recently, we reported that pH-responsive hollow particles could be prepared using solvent evaporation [Bird et al., Chem. Commun., 2011, 47, 1443. Here, we greatly expand and extend that work by investigating four new pH-responsive hollow particle systems based on poly(MMA-co-MAA) (methyl methacrylate and methacrylic acid) and poly(EA-co-MAA) (EA is ethyl acrylate). The hollow polymer particles were crosslinked with cystamine after preparation to give redox sensitive, biodegradable, hollow particles. For one of the systems a remarkable particle-in-hollow particle morphology was observed. The pH-triggered swelling of the hollow particles was studied and pH-triggered release of a model solute from these new hollow particles was demonstrated. The dispersions formed physical gels in the physiological pH range. The hollow particle physical gels had elastic modulus values as high as 4000 Pa at low total polymer concentrations. The swelling properties of the particles and the mechanical properties of the gels were tuneable using copolymer composition. The particles and gels could be disassembled with glutathione. The properties of these new gel-forming dispersions imply they have good potential for future application as injectable gels for regenerative medicine.

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“…The fabrication is based on the set-wise assembly of oppositely charged polyelectrolytes onto a sacricial template before the decomposition of its core. 2,3 PMCs have attracted immense attention due to their great applicability in various scientic elds, such as in medical imaging, 4,5 controlled drug delivery systems, 6 biosensors, 7,8 synthetic vaccines, 9 cell encapsulation, 10 nanoreactors, 11 catalysts 12 and many others. Due to the high versatility of the LbL technique, different properties of the capsules can be easily tailored, e.g.…”

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confidence: 99%

Liquified chitosan–alginate multilayer capsules incorporating poly(l-lactic acid) microparticles as cell carriers

Correia¹,

Sher²,

Reis³

et al. 2013

Soft Matter

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Facile Fabrication of Stimuli‐Responsive Polymer Capsules with Gated Pores and Tunable Shell Thickness and Composite

Cited by 29 publications

References 45 publications

CPMV-induced synthesis of hollow mesoporous SiO₂nanocapsules with excellent performance in drug delivery

CPMV-induced synthesis of hollow mesoporous SiO₂nanocapsules with excellent performance in drug delivery

Tuning the properties of pH-responsive and redox sensitive hollow particles and gels using copolymer composition

Liquified chitosan–alginate multilayer capsules incorporating poly(l-lactic acid) microparticles as cell carriers

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Facile Fabrication of Stimuli‐Responsive Polymer Capsules with Gated Pores and Tunable Shell Thickness and Composite

Cited by 29 publications

References 45 publications

CPMV-induced synthesis of hollow mesoporous SiO2nanocapsules with excellent performance in drug delivery

CPMV-induced synthesis of hollow mesoporous SiO2nanocapsules with excellent performance in drug delivery

Tuning the properties of pH-responsive and redox sensitive hollow particles and gels using copolymer composition

Liquified chitosan–alginate multilayer capsules incorporating poly(l-lactic acid) microparticles as cell carriers

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Product

Resources

About

CPMV-induced synthesis of hollow mesoporous SiO₂nanocapsules with excellent performance in drug delivery

CPMV-induced synthesis of hollow mesoporous SiO₂nanocapsules with excellent performance in drug delivery