Facile fabrication of pH-responsive nanoparticles from cellulose derivatives via Schiff base formation for controlled release

Engineered bovine serum albumin-based nanoparticles with pH-sensitivity for doxorubicin delivery and controlled release

“…Anticancer drug DOX is physically loaded into the BSA-based NPs using desolvation method, resulting in DOXloaded BSA NPs (named after DOX@BSA NPs). And then, glutaraldehyde is used to crosslink the BSA through the interaction between aldehyde and amine residues, resulting in Schiff base bond which is pH-sensitive (named after DOX s @BSA NPs) (Feng et al 2017;Peng et al 2019;Xu et al 2019). The physicochemical properties of DOX s @BSA NPs including particle size, zeta-potential, serum stability, drug release behavior and mechanism, and cytotoxicity were investigated by a variety of experimental techniques.…”

Electrochemical and spectroscopic characterization of biologically important Schiff bases

“…Value of entropy became less negative with increasing temperature and it indicates that electrode reaction becomes less ordered with increased temperature. Dependence of ΔG # and ΔS # on temperature implies that processes are both enthalpy and entropy driven [38][39][40]. This also shows that these redox processes are nonspontaneous, and entropy opposed but become facile to some degree as temperature increases.…”

“…ΔG # , ΔH # and ΔS # at different temperatures were evaluated by using following simple relations [39]. On using Arrhenius type equation and by plotting ln k s vs. 1/T, value of activation energy can be found which is useful in determining the values of ΔH # at corresponding temperatures by utilizing following relation [40] While knowing the values of ΔG # and ΔH # at different temperatures, value of ΔS # at corresponding temperatures can be evaluated by using following well known relation Temperature elevation intensified the peak current which was attributed to the fact that as temperature rise, solvation sphere between the electroactive moiety of the analyte and electrode surface shrinks, subsequently increasing the sensitivity of electrode and making the approach of analyte more viable towards electrode. Moreover, increase in temperature resulted in cathodic shift of peak potential.…”

Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers

“…Polymer‐based prodrugs formed by conjugation of anticancer drugs to polymeric chains using acid‐labile linkers offer several advantages over their free‐form counterparts, including good protection during drug circulation and enhanced drug bioavailability. The cleavage of these chemical linkages in the acidic environment leads to the activation and release of cytotoxic chemotherapy agents at the desired sites of action from the polymeric prodrug and can therefore minimize the side effects . Zhang and co‐workers designed cellulose derivatives by conjugating 2,3‐dialdehyde cellulose (DAC) with oleylamine and aminoethyl rhodamine (AERhB) via Schiff base bonds.…”

“…Zhang and co‐workers designed cellulose derivatives by conjugating 2,3‐dialdehyde cellulose (DAC) with oleylamine and aminoethyl rhodamine (AERhB) via Schiff base bonds. AERhB was used as a model anticancer drug . It was demonstrated that the Schiff base bonds in nanoparticles (NPs) allowed the efficient release of drug in the acidic tumor microenvironment by cleaving the Schiff base linkages.…”