Abstract:Photothermal therapy has attracted much interest for use in cancer treatment in recent years. In this study, Cu Se nanoparticles as a novel photothermal agent modified by chitosan (CS-Cu SeNPs) were successfully synthesized through a facile route at room temperature. The as-synthesized CS-Cu SeNPs exhibited good water solubility and significant stability. CS-Cu SeNPs can efficiently convert near-infrared (NIR) light into heat and exhibit excellent thermostability. In vitro experiments showed that CS-Cu SeNPs h… Show more
“…The PLGA ‑SS‑ DMMA-FITC was prepared to study the cellular fluorescence localization of the nanosystem . A 2 mL amount of A375 cells at 4 × 10 4 cells/mL was seeded on a 2 cm dish and incubated with PLGA ‑SS‑ DMMA-FITC (1 μg/mL).…”
Section: Methodsmentioning
confidence: 99%
“…The PLGA -SS-DMMA-FITC was prepared to study the cellular fluorescence localization of the nanosystem. 52 A 2 mL amount of A375 cells at 4 × 10 4 cells/mL was seeded on a 2 cm dish and incubated with PLGA -SS-DMMA-FITC (1 μg/mL). DAPI and Lysotracker were used to stain the cells before observation at 0.5 and 2 h. The cells were washed by PBS and observed by fluorescence microscopy (IX51, Olympus).…”
Cancer
radiotherapy suffers from drawbacks such as radiation resistance
of hypoxic cells, excessive radiation that causes damage of adjacent
healthy tissues, and concomitant side effects. Hence, radiotherapy
sensitizers with improved radiotherapeutic performance and requiring
a relatively small radiation dose are highly desirable. In this study,
a nanosystem based on poly(lactic-co-glycolic acid)
(PLGA) and ultrasmall black phosphorus quantum dots (BPQDs) is designed
and prepared to accomplish precise tumor radiosensitization. The PLGA
nanoparticles act as carriers to package the BPQDs to avoid off-target
release and rapid degradation during blood circulation. The nanosystem
that targets the polypeptide peptide motif Arg-Gly-Asp-Gys actively
accumulates in tumor tissues. The 2,3-dimethylmaleic anhydride shell
decomposes in an acidic microenvironment, and the nanoparticles become
positively charged, thereby favoring cellular uptake. Furthermore,
glutathione (GSH) deoxidizes the disulfide bond of cystamine and sequentially
triggers release of BPQDs, rendering tumor cells sensitive to radiotherapy.
The treatment utilizing the PLGA‑SS‑D@BPQDs
nanosystem and X-ray induces cell apoptosis triggered by overproduction
of reactive oxygen species. In the in vivo study,
the nanosystem shows excellent radiotherapy sensitization efficiency
but negligible histological damage of the major organs. This study
provides insights into the design and fabrication of surface-charge-switching
and pH-responsive nanosystems as potent radiosensitizers to achieve
excellent radiotherapy sensitization efficacy and negligible toxic
side effects.
“…The PLGA ‑SS‑ DMMA-FITC was prepared to study the cellular fluorescence localization of the nanosystem . A 2 mL amount of A375 cells at 4 × 10 4 cells/mL was seeded on a 2 cm dish and incubated with PLGA ‑SS‑ DMMA-FITC (1 μg/mL).…”
Section: Methodsmentioning
confidence: 99%
“…The PLGA -SS-DMMA-FITC was prepared to study the cellular fluorescence localization of the nanosystem. 52 A 2 mL amount of A375 cells at 4 × 10 4 cells/mL was seeded on a 2 cm dish and incubated with PLGA -SS-DMMA-FITC (1 μg/mL). DAPI and Lysotracker were used to stain the cells before observation at 0.5 and 2 h. The cells were washed by PBS and observed by fluorescence microscopy (IX51, Olympus).…”
Cancer
radiotherapy suffers from drawbacks such as radiation resistance
of hypoxic cells, excessive radiation that causes damage of adjacent
healthy tissues, and concomitant side effects. Hence, radiotherapy
sensitizers with improved radiotherapeutic performance and requiring
a relatively small radiation dose are highly desirable. In this study,
a nanosystem based on poly(lactic-co-glycolic acid)
(PLGA) and ultrasmall black phosphorus quantum dots (BPQDs) is designed
and prepared to accomplish precise tumor radiosensitization. The PLGA
nanoparticles act as carriers to package the BPQDs to avoid off-target
release and rapid degradation during blood circulation. The nanosystem
that targets the polypeptide peptide motif Arg-Gly-Asp-Gys actively
accumulates in tumor tissues. The 2,3-dimethylmaleic anhydride shell
decomposes in an acidic microenvironment, and the nanoparticles become
positively charged, thereby favoring cellular uptake. Furthermore,
glutathione (GSH) deoxidizes the disulfide bond of cystamine and sequentially
triggers release of BPQDs, rendering tumor cells sensitive to radiotherapy.
The treatment utilizing the PLGA‑SS‑D@BPQDs
nanosystem and X-ray induces cell apoptosis triggered by overproduction
of reactive oxygen species. In the in vivo study,
the nanosystem shows excellent radiotherapy sensitization efficiency
but negligible histological damage of the major organs. This study
provides insights into the design and fabrication of surface-charge-switching
and pH-responsive nanosystems as potent radiosensitizers to achieve
excellent radiotherapy sensitization efficacy and negligible toxic
side effects.
“…Copper-based nanomaterials have been receiving great attention due to their unique properties. Especially for copper selenide (Cu 2 Se) and copper oxide (CuO), as typical p-type semiconductors, they have potential applications in the fields of thermoelectric conversion, catalysis, therapy, sensors, and so on. − Generally, the structure and morphology of nanomaterials can make a significant impact on their properties. On the basis of this view, various nanostructures of the above-mentioned two materials have also been developed.…”
Cu 2 Se nanobelts have been developed via a facile cation-exchange approach at room temperature, employing ZnSe•0.5N 2 H 4 hybrid nanobelts as the templated precursors. Detailed characterizations demonstrate that the morphologies of the templated precursors are well-preserved in the cation-exchange reaction, because of the spatial confinement effect from the coated layer of poly-(vinylpyrrolidone) (PVP) surfactant. Simultaneously, Cu 2+ cations diffusing through the coated layer of PVP are in situ reduced to be Cu + cations by the ligands of N 2 H 4 , thereby forming Cu 2 Se nanobelts with the complete replacement of Zn 2+ cations in the templated precursors. After thermal oxidation in air, the obtained Cu 2 Se nanobelts are further converted into porous CuO nanobelts. Considering that this special morphology processes a large active surface area and is favorable for gas diffusion, gas-sensing properties of porous CuO nanobelts have been explored. The results indicate that porous CuO nanobelts exhibit highly selective sensing toward H 2 S with a low detection limit less than 10 ppb. Moreover, they also present a good sensing reproducibility. Finally, their sensing mechanism toward H 2 S has been discussed.
“…Among exogenous stimuli, lasers have the advantages of convenience and effectiveness, leading to the wide application of photocontrolled GRNs [ 33 – 37 ]. Compared to ultraviolet or visible light with limited tissue penetration depth, NIR light has higher tissue penetration depth and lower phototoxicity and therefore exhibits broader application prospects in cancer gas treatment [ 38 – 40 ]. Scheme 1 Schematic illustration of NIR light triggered nano-prodrug for cancer gas therapy …”
Gas therapy (GT) has attracted increasing attention in recent years as a new cancer treatment method with favorable therapeutic efficacy and reduced side effects. Several gas molecules, such as nitric oxide (NO), carbon monoxide (CO), hydrogen (H2), hydrogen sulfide (H2S) and sulfur dioxide (SO2), have been employed to treat cancers by directly killing tumor cells, enhancing drug accumulation in tumors or sensitizing tumor cells to chemotherapy, photodynamic therapy or radiotherapy. Despite the great progress of gas therapy, most gas molecules are prone to nonspecific distribution when administered systemically, resulting in strong toxicity to normal tissues. Therefore, how to deliver and release gas molecules to targeted tissues on demand is the main issue to be considered before clinical applications of gas therapy. As a specific and noninvasive stimulus with deep penetration, near-infrared (NIR) light has been widely used to trigger the cleavage and release of gas from nano-prodrugs via photothermal or photodynamic effects, achieving the on-demand release of gas molecules with high controllability. In this review, we will summarize the recent progress in cancer gas therapy triggered by NIR light. Furthermore, the prospects and challenges in this field are presented, with the hope for ongoing development.
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