Facile fabrication of biocompatible PLGA drug-carrying microspheres by O/W pickering emulsions

An Overview of Pickering Emulsions: Solid-Particle Materials, Classification, Morphology, and Applications

“…Besides, the use of SiO 2 has another convenience, since the outer silica shell can get removed by simply washing with HF aqueous solution, so that bare polymer-MSs could be obtained with better biocompatibility (Wei et al, 2012a). …”

“…In this respect, pure PLGA micro-particles could be an ideal goal for in vivo drug delivery, which has already been fabricated by firstly forming Pickering emulsion using SiO 2 nanoparticles as stabilizer, and etching off SiO 2 after solvent evaporation (Wei et al, 2012a). Drug-loading and drug-releasing experiments indicated that pH had significant influence on both IBU-loading efficiency and releasing profile.…”

Mesoporous silica core–shell composite functionalized with polyelectrolytes for drug delivery

“…The shell is usually non-toxic, biodegradable, inert and biocompatible, such as polyethylene-glycol (PEG), poly(D,L-lactic acid) and poly(D,L-lactic-co-glycolic acid) (PLGA) [18,19]. PEI has been used in gene therapy as a delivery agent because it can bind to anionic cell surface [20,21].…”

Mineralization and drug release of hydroxyapatite/poly( l -lactic acid) nanocomposite scaffolds prepared by Pickering emulsion templating

“…The fabrication procedure involves first preparing a Pickering emulsion and then solidifying the emulsion continuous phase. Pickering emulsion is a solid particle-stabilized emulsion [26][27][28][29][30][31][32], where solid particles are nearly irreversibly adsorbed at liquid-liquid interfaces and act as a barrier against coalescence making the resulted emulsions extremely stable [33][34][35][36]. Thus, Pickering emulsion templates are stable enough to maintain the designed porous structures in the fabrication procedure.…”