Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy

Wan, Hao; Zhang, Yi; Liu, Zheyi; Xu, Guiju; Huang, Guang; Ji, Yongsheng; Xiong, Zhi‐Chao; Zhang, Quanqing; Dong, Jing; Zhang, Weibing; Zou, Hanfa

doi:10.1039/c4nr01044b

Cited by 64 publications

(35 citation statements)

References 56 publications

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“…214 Reduced GO nanosheets decorated with mesoporous silica shells have been developed for use in assisted spatiotemporally controlled chemo-photothermal synergistic cancer therapy; they can generate heat under NIR irradiation, and can kill cancer cells very efficiently through the hypothermia effect. 215 Drug delivery systems aim to localize delivery of therapeutic agents, in which GO is predominantly used because it can create barrier layers in multilayer thin films, trapping molecules of interest for controlled release. 216 NGO-PEG has been used as a nanocarrier for delivery of water-insoluble aromatic anticancer drugs into cells.…”

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confidence: 99%

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Gurunathan¹,

Kim²

2016

IJN

239

140

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Graphene is a two-dimensional atomic crystal, and since its development it has been applied in many novel ways in both research and industry. Graphene possesses unique properties, and it has been used in many applications including sensors, batteries, fuel cells, supercapacitors, transistors, components of high-strength machinery, and display screens in mobile devices. In the past decade, the biomedical applications of graphene have attracted much interest. Graphene has been reported to have antibacterial, antiplatelet, and anticancer activities. Several salient features of graphene make it a potential candidate for biological and biomedical applications. The synthesis, toxicity, biocompatibility, and biomedical applications of graphene are fundamental issues that require thorough investigation in any kind of applications related to human welfare. Therefore, this review addresses the various methods available for the synthesis of graphene, with special reference to biological synthesis, and highlights the biological applications of graphene with a focus on cancer therapy, drug delivery, bio-imaging, and tissue engineering, together with a brief discussion of the challenges and future perspectives of graphene. We hope to provide a comprehensive review of the latest progress in research on graphene, from synthesis to applications.

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confidence: 99%

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Gurunathan¹,

Kim²

2016

IJN

239

140

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“…There are many reports on biocompatibility of near-IR irradiation. As described, due to convenient and precise manipulation, deep penetration through tissues and excellent biocompatibility, near-IR irradiation is a preferred external stimulus for triggering the release of loaded drugs [23].…”

Section: Discussionmentioning

confidence: 99%

Near-IR absorbing quantum dots might be usable for growth factor-based differentiation of stem cells

Niknejad

Mirmasoumi

Torabi

et al. 2015

Journal of Medical Hypotheses and Ideas

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For stem cell therapy of degenerative diseases, it is necessary to differentiate stem cells into the specific lineage. There are several growth factors which have been used for differentiation of stem cells. Some growth factors can dose-dependently induce differentiation of stem cells so that the increase of growth factor concentration results in production of the higher level of differentiated cells. However, due to the toxicity of some differentiation factors (e.g. retinoic acid), the lower dose of growth factors for the specific lineage differentiation of stem cells is desirable. This paper suggests a new approach in the field of controlled growth factor delivery system using semiconductor nanocrystals; known as quantum dots (QDs). This system contains polymeric microencapsulated growth factor which is conjugated to near infrared (NIR) absorbing QDs. The control release of growth factors from microcapsules in the culture plates can be achieved by irradiation. To modulate growth factor release in response to stem cells needs for differentiation, the intensity and period of irradiation will be controlled. Our hypothesis is based on the fact that QDs can absorb NIR energy and by excitation of electrons and then vibrational relaxation of them become heated when they were irradiated and then release growth factors. We believe that controlled growth factors delivery through the suggested system is an effective method to reduce the amount of growth factors required for differentiation of stem cells.

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“…In addition to all these studies, several other graphene-based nanotherapeutic platforms such as CuS nanoparticle decorated GO, PEGylated graphene nanoribbons, Fe 3 O 4 nanoparticle loaded GO nanocomposites have been developed for combined chemo-photothermal therapy of cancer. [103][104][105][106][107][108] …”

Section: Combined Chemo-pttmentioning

confidence: 99%

Graphene-Based Nanomaterials for Theranostic Applications

Roy

Jaiswal

2017

Rep. Adv. Phys. Sci.

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Graphene and graphene-based nanomaterials such as graphene oxide (GO), reduced graphene oxide (rGO) and graphene quantum dots (GQDs) have gained a lot of attention from diverse scienti¯c¯elds for applications in sensing, catalysis, nanoelectronics, material engineering, energy storage and biomedicine due to its unique structural, optical, electrical and mechanical properties. Graphene-based nanomaterials emerge as a novel class of nanomedicine for cancer therapy for several reasons. Firstly, its structural properties like high surface area and aromaticity enables easy loading of hydrophobic drugs. Secondly, presence of oxygen containing functional groups improve its physiological stability and also act as site for biofunctionalization. Thirdly, its optical absorption in the NIR region enable them to act as photoagents for photothermal and photodynamic therapies of cancer, both in vitro and in vivo. Finally, its intrinsic°u orescence property helps in bioimaging of cancer cells. Overall, graphene-based nanomaterials can act as agents for developing multifunctional theranostic platforms for carrying out more e±cient detection and treatment of cancers. This review provides a detailed summary of the di®erent applications of graphene-based nanomaterials in drug delivery, nucleic acid delivery, phototherapy, bioimaging and theranostics.

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Facile fabrication of a near-infrared responsive nanocarrier for spatiotemporally controlled chemo-photothermal synergistic cancer therapy

Cited by 64 publications

References 56 publications

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Near-IR absorbing quantum dots might be usable for growth factor-based differentiation of stem cells

Graphene-Based Nanomaterials for Theranostic Applications

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