Facile and Selective Synthesis of Chloromethylpyridines and Chloropyridines Using Diphosgene/Triphosgene.

Narendar, P.; Gangadasu, B.; Ramesh, C.; Raju, B. China; Rao, V. Jayathirtha

doi:10.1002/chin.200432159

Cited by 2 publications

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“…However, there are no reports of the use of ammonium salts as catalysts for the synthesis of benzimidazoles. In continuation, on the synthesis of heterocycles 13,14 and on the development of synthetic methodologies 15,17 , we herein report a facile method for the synthesis of benzimidazoles by the reaction between amines derivatives and o-phenylenediamine in dimethyl formamide (DMF) as solvent in the presence of iodine as a catalyst, in very good yields.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2012

IJPSR

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The synthesis of benzimidazoles derivative involves subsequent synthesis of 4-(2-chloro-ethoxy)-benzaldehyde, 4 methyl benzaldehyde followed by benzimidazoles derivative by reaction between amines derivatives and ophenylenediamine in dimethyl farmamide (DMF) as solvent in the presence of iodine as a catalyst. Iodine is a commercial and environmentally benign catalyst. The yield of all benzimidazole derivatives was found to be in the range of 75-94%. The purity of the compounds was ascertained by melting point and TLC. The synthesized compounds were characterized by using IR, 1 H NMR, and MASS spectral data together with elemental analysis. The synthesized benzimidazole compounds were screened for analgesic and anticonvulsant activity in albino rat (100-200gm) by using Writhing test and maximal electroshock (MES). Out of all compound studied only PS-3, PS-4, PS-5 and PS-6 showed significant analgesic activities and response against MES test.

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Section: Introductionmentioning

confidence: 99%

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2012

IJPSR

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“…[12] However, there are no reports of the use of ammonium salts as catalysts for the synthesis of benzimidazoles. In continuation, on the synthesis of heterocycles[1314] and on the development of synthetic methodologies,[15–17] we herein report a facile method for the synthesis of benzimidazoles by the condensation of 1, 2-phenylenediamine with carbonyl compounds, in the presence of ammonium salts in very good yields. Anxiety is a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Biological Evaluation of Benzimidazole Derivatives as Potential Anxiolytics

Nannapaneni¹,

Av²,

Reddy³

et al. 2010

Journal of Young Pharmacists

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The synthesized benzimidazoles compounds were prepared from the condensation reaction between o-Phenylenediamine and various carbonyl compounds, in the presence of ammonium chloride as a catalyst. Ammonium chloride is a commercial and environmentally benign catalyst. The yield of all benzimidazole derivatives was found to be in the range of 75 – 94%. The purity of the compounds was ascertained by melting point and TLC. The synthesized compounds were characterized by using IR,1H NMR, and MASS spectral data together with elemental analysis. The synthesized benzimidazole compounds were screened for acute and chronic anti-anxiety activity in Wistar rats by using an elevated plus maze model with standard Diazepam. The synthesized compounds ZB, ZE, ZF, ZG, and ZH showed potent anti-anxiety activity when compared to the standard Diazepam. The compound ZH exhibited a higher anti-anxiety activity when compared to other prepared benzimidazoles. The results were subjected to statistical analysis by using one-way ANOVA followed by the Tukey-Kramer test, to calculate the significance.

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Facile and Selective Synthesis of Chloromethylpyridines and Chloropyridines Using Diphosgene/Triphosgene.

Cited by 2 publications

References 1 publication

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Synthesis, Characterization, and Biological Evaluation of Benzimidazole Derivatives as Potential Anxiolytics

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