Abstract:In this work, we present a simple, straightforward, and robust method for spontaneously digitizing samples into an array of dis-crete volumes. The method is based on an oil-triggered, template-confined dewetting phenomenon. To realize the dewetting-induced sample digitization, an aqueous sample is firstly infused into a networked microwell array (NMA) through a predegassing-based self-pumping mechanism, and then an immiscible oil phase is applied over the surface of NMA chip to induce the templated dewetting. … Show more
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