Abstract:A multistep and diversity‐oriented synthetic route aiming at the A3 coupling/domino cyclization of o‐ethynyl anilines, aldehydes and s‐amines is described. The preparation of the corresponding precursors included a series of transformations, such as haloperoxidation and Sonogashira cross‐coupling reactions, amine protection, desilylation and amine reduction. Some products of the multicomponent reaction underwent further detosylation and Suzuki coupling. The resulting library of structurally diverse compounds w… Show more
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