Facial rash and ocular pain

Fernández‐Nieto, Diego; Salvá-Palomeque, Teresa

doi:10.1136/bmj.n1965

Cited by 1 publication

(3 citation statements)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SARS-CoV-2 pandemic rapidly spread around the entire globe and continues to pose a major global health challenge [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ]. Although the involvement of the lungs and airways was immediately clear [ 56 ], as time went on, the possibility of the involvement of different organs, including the skin, became increasingly evident.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, our data are in agreement with the paper by Garduno-Soto et al [ 80 ], which describes a near-absence of TMRPSS2 expression at the skin level, postulating that cutaneous manifestations from SARS-CoV-2 were more attributable to paracrine or endocrine (circulating) factors than to the “effective” binding of the virion to a specific skin cell type. With regard to this aspect, there are also different interpretations in the various works present in the literature [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ,…”

Section: Discussionmentioning

confidence: 99%

“…Regarding skin involvement, reports of different eruption patterns became very frequent and numerous, both in the adult and pediatric population, first in China and then gradually throughout the globe [ 14 , 15 , 16 ]. Among the different cutaneous manifestations of COVID-19, erythematous rashes [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ], pseudo-chilblains [ 24 , 25 , 26 ], acro-ischemia and livedoid lesions [ 27 , 28 , 29 , 30 , 31 , 32 ] or other cutaneous manifestations resembling pityriasis rosea, erythema elevatum diutinum, erythema multiforme and Grover disease have been reported [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

SARS-CoV-2 and Skin: New Insights and Perspectives

Cazzato

Cascardi²,

Colagrande³

et al. 2022

Biomolecules

View full text Add to dashboard Cite

The SARS-CoV-2 pandemic has disrupted global health systems and brought the entire globe to its knees. Although born as a disease of the respiratory system, COVID-19 can affect different parts of the body, including the skin. Reports of ongoing skin manifestations of COVID-19 have gradually multiplied, pushing researchers to investigate the etiopathogenic mechanisms underlying these phenomena in more depth. In an attempt to investigate the possible association between SARS-CoV-2, ACE2, TMPRSS2 and skin manifestations, we performed immunohistochemical investigations of the ACE2 receptor and TMPRSS2 in nine skin samples from SARS-CoV-2-positive patients compared to a cohort of healthy controls. Furthermore, after consulting public databases regarding ACE2 mRNA expression in various cell populations resident in the skin, we conducted a literature review aimed at outlining the current state of this topic. We did not find statistically different immuno-expression of ACE2 and TMPRSS2 between the group of SARS-CoV-2-positive patients (nine skin biopsies) and the control group. Regarding ACE2, major immunolabeling was present in the epidermal keratinocytes and, rarely, in the fibroblasts and in the adenomeres of the eccrine sweat glands. Regarding the immune expression of TMPRSS2, we found no significant differences between the two groups, with a weak immune staining only in some skin cytotypes. From the review of the literature, we isolated 35 relevant articles according to the inclusion criteria adopted. ACE2 appears to be a target of SARS-CoV-2, although, other receptor molecules may potentially be implicated, such as TMPRSS2. Future studies with large cases and different molecular investigative methods are needed to further elucidate the mechanisms underlying the skin manifestations of SARS-CoV-2.

show abstract