Facial porokeratosis: A series of six patients

Abstract

Porokeratosis is a disorder of epidermal keratinization characterized by annular plaques with an atrophic centre and hyperkeratotic edges, and includes a heterogeneous group of disorders that are mostly inherited in an autosomal dominant fashion. Facial porokeratosis is rare and is not well documented. We present six cases of facial porokeratosis seen over a period of 15 years in a hospital in Lima, Peru. In most of the cases, porokeratosis was found in younger women without any significant past medical history. Oral isotretinoin showed moderate improvement in two of our patients.

Localised nasal actinic porokeratosis: An independent subtype of porokeratosis?

“…Interestingly, this case had gross similarity to the single largest published series (12 female and 3 male patients) [1] and the subsequent individual case reports of nasal PK [5,[7][8][9].…”

“…Common sites of predilection are trunk and extremities although sporadic cases of involvement of palms and soles, face, oral mucosa, lips have been reported [5]. The present study highlights the high incidence of nasal PK among the reported cases in the world literature which is clinically and epidemiologically distinct from other types of PK.…”

“…The usual pattern of inheritance is autosomal dominant but at times it may be sporadic. A few of these subtypes exhibit propensity for malignant transformation as conversion into squamous cell carcinoma, Bowen disease and basal cell carcinoma has been described in 6.8 -11.0% cases of PK [5].…”

Off-label uses of retinoids in dermatology

“…Porokeratosis was found in younger women without any significant past medical history. Oral isotretinoin showed moderate improvement [73][74][75].…”

“…Compared with the other current combination or single treatments of lichen planus, acitretin is the first-line therapy for cutaneous lichen planus. Seven patients whose lesions were resistant to other treatments received isotretinoin for painful oral lichen planus as well as generalized pruritic lichen planus, and good to excellent results during the treatment, which never exceeded 2 months, were obtained [74]. Among all systemic retinoids, only acitretin has shown a relatively good level of evidence of its efficacy in the treatment of cutaneous lichen planus [166].…”