Facial Palsy in Melkersson-Rosenthal Syndrome and Bell’s Palsy

Sun, Baochun; Zhou, Changjiang; Han, Zeli

doi:10.1177/0003489414546398

Cited by 10 publications

(7 citation statements)

References 17 publications

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“…In a Chinese case series of 16 patients with facial palsy in MRS, familial history was positive in about one third of the patients (31.3%) 27 . However, none of the patients of our cohort presented familial history.…”

Section: Discussionmentioning

confidence: 56%

“…In a Chinese case series of 16 patients with facial palsy in MRS, familial history was positive in about one third of the patients (31.3%). 27 However, none of the patients of our cohort presented familial history. In some cases, neuroimaging is helpful to identify edema and thickening of facial soft tissues, as well as inflammation of the cranial nerves.…”

Section: Pathogenesis Histological Aspects and Differential Diagnosismentioning

confidence: 78%

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Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature

Galdiero

Maio

Arcoleo

et al. 2021

Allergy

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Background Orofacial granulomatosis (OFG) is characterized by granulomatous inflammation of the soft tissues of maxillofacial region. We explored OFG patients from 10 different Italian centers and summarized the most recent literature data. Methods A review of patients with OFG was carried out. An extensive online literature search was performed to identify studies reporting diagnosis and management of OFG. Results Thirty‐nine patients were recruited between January 2018 and February 2020. Most of them (97.4%) displayed involvement of the lips, and 28.2% suffered from Melkersson‐Rosenthal syndrome. Two patients received diagnosis of CD and one patient of sarcoidosis, suggesting secondary OFG. Oral aphthosis and cervical lymphadenopathy were also described. The mean diagnostic delay was 3.4 years. Histological evaluation was performed in 34/39 patients (87.2%); non‐caseating granulomas were found in 73.5% of them. Neurological symptoms (28.2%), gastrointestinal symptoms in absence of overt inflammatory bowel disease (IBD) (20.5%), and atopy (35.9%) were also identified. Therapeutic approaches varied among the centers. Steroids (51.3%) were used with good or partial results. Anti‐TNF‐α and anti‐IgE monoclonal antibodies were used in 6 (15.4%) and 1 (2.6%) patients, respectively, with variable results. Surgery was the choice for 2 patients with good response. Conclusions OFG is a rare and neglected disease showing multiple clinical phenotypes. While early diagnosis is crucial, management is difficult and highly dependent on the expertise of clinicians due to the lack of international guidelines. There is a need to establish registry databases and address challenges of long‐term management.

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Section: Discussionmentioning

confidence: 56%

Section: Pathogenesis Histological Aspects and Differential Diagnosismentioning

confidence: 78%

Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature

Galdiero

Maio

Arcoleo

et al. 2021

Allergy

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“…Only Patient 1 had a positive family history for signs and symptoms of MRS, her father being affected by recurrent peripheral facial palsy. A prospective investigation by Sun and colleagues showed that familial history for recurrent facial palsy was significantly higher in MRS (31.3%) than in Bell’s palsy (6.5%) [43]. However, genetic investigations have not yet identified single causative genes, and there is both clinical and genetic heterogeneity in MRS patients [44].…”

Section: Discussionmentioning

confidence: 99%

Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature

Savasta

Rossi

Foiadelli

et al. 2019

IJERPH

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Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses.

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“…3 The patient's family history indicates a possible autosomal dominant inheritance with female-to-female vertical transmission with affected members in 3 generations, and this pattern has been described by other authors as well. 4 However, no single genetic alteration has been associated with MRS up todate. 5 The prognosis of MRS is more guarded compared with Bell palsy because the orofacial edema tends to be recurrent and unresponsive to therapy and facial palsy may recur over a long period of time, even up to 60 years of age.…”

Section: Recurrent Facial Palsy In a Teenagermentioning

confidence: 99%

Recurrent Facial Palsy in a Teenager

Angeli

Vergadi

Tsiverdis

et al. 2021

The Journal of Pediatrics

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Facial Palsy in Melkersson-Rosenthal Syndrome and Bell’s Palsy

Abstract: Compared to Bell's palsy, facial palsy in MRS has an obvious genetic predilection and recurrence tendency.

Cited by 10 publications

References 17 publications

Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature

Orofacial granulomatosis: Clinical and therapeutic features in an Italian cohort and review of the literature

Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature

Recurrent Facial Palsy in a Teenager

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