Facial frequency manipulation normalizes face discrimination in AD

Cronin‐Golomb, Alice; Cronin-Golomb, M.; Dunne, T.E.; Brown, Alston; Jain, Kajal; Cipolloni, Patsy Benny; Auerbach, Sanford

doi:10.1212/wnl.54.12.2316

Cited by 29 publications

(17 citation statements)

References 9 publications

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“…However, we excluded studies where prosopagnosia was a symptom of a more global deficit such as in cases of neurodegenerative disease (Cronin-Golomb et al, 2000; Turan et al, 2013) and autism spectrum disorder (Weigelt et al, 2012). …”

Section: Methods Of Search and Selection Criteriamentioning

confidence: 99%

Face processing improvements in prosopagnosia: successes and failures over the last 50 years

DeGutis

Chiu

Grosso

et al. 2014

Front. Hum. Neurosci.

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Clinicians and researchers have widely believed that face processing cannot be improved in prosopagnosia. Though more than a dozen reported studies have attempted to enhance face processing in prosopagnosics over the last 50 years, evidence for effective treatment approaches has only begun to emerge. Here, we review the current literature on spontaneous recovery in acquired prosopagnosia (AP), as well as treatment attempts in acquired and developmental prosopagnosia (DP), differentiating between compensatory and remedial approaches. We find that for AP, rather than remedial methods, strategic compensatory training such as verbalizing distinctive facial features has shown to be the most effective approach (despite limited evidence of generalization). In children with DP, compensatory training has also shown some effectiveness. In adults with DP, two recent larger-scale studies, one using remedial training and another administering oxytocin, have demonstrated group-level improvements and evidence of generalization. These results suggest that DPs, perhaps because of their more intact face processing infrastructure, may benefit more from treatments targeting face processing than APs.

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Section: Methods Of Search and Selection Criteriamentioning

confidence: 99%

Face processing improvements in prosopagnosia: successes and failures over the last 50 years

DeGutis

Chiu

Grosso

et al. 2014

Front. Hum. Neurosci.

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“…These visual capacities include color discrimination, especially on the blue-yellow axis, 17,[19][20][21] and contrast sensitivity. [17][18][19][22][23][24][25][26] Reductions in contrast sensitivity alone have been linked with numerous perceptual, cognitive, and behavioral abnormalities in AD. 18,[27][28][29] In normal observers, increased stimulus contrast is associated with decreases in search time, number of fixations per search, and fixation duration.…”

mentioning

confidence: 99%

Characteristics of Visual Target Influence Detection of Change in Naturalistic Scenes in Alzheimer Disease

Neargarder

Cronin‐Golomb²

2005

Cognitive and Behavioral Neurology

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“…For most people, contrast sensitivity is less acute at low and high relative to mid-range frequencies, producing the characteristic contrast sensitivity curve. Many investigators have reported contrast sensitivity deficits in AD patients [1][2][3][4][23][24][25][26][27][28], but the extent of impairment varies from study to study. In our recent investigation [7], we examined the two main potential explanations for such variability in the degree of impairment besides sample differences: acuity differences between AD and control groups, discussed above, and choice of assessment methods.…”

Section: Contrast Sensitivitymentioning

confidence: 99%

“…Deficits in spatial frequency contrast sensitivity result in increased difficulty in face discrimination in healthy elderly individuals [e.g., 29] and especially in patients with AD [24,28]. As described above, the spatial frequency of conventional grating stimuli is measured in cpd.…”

Section: Contrast Sensitivity Relation To Face Discriminationmentioning

confidence: 99%

“…When the stimulus is a face, face-width is the measure of overall size, the unit of measure is cycles per face (cpf) rather than cpd, and we refer to the facial frequency. In our study of the relation of contrast sensitivity to face discrimination in AD [24], we varied the size of target faces to induce shifts in the sensitivity curve. The hypothesis was that we could use the natural frequency response of the visual system to enhance the perception of the low facial frequency content and thereby enhance discrimination of face stimuli in AD patients, who have poor sensitivity especially at low spatial frequencies, as described above [1][2][3].…”

Section: Contrast Sensitivity Relation To Face Discriminationmentioning

confidence: 99%

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Heterogeneity of Visual Presentation in Alzheimer's Disease

Cronin‐Golomb¹

2004

Interdisciplinary Topics in Gerontology

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Researchers who study Alzheimer's disease (AD) are well acquainted with the heterogeneity of its presentation, and clinicians are challenged daily to apply research findings to the behavior of individuals with the disorder. With the growing consensus that visual deficits are common and significant in AD, as illustrated by the work described in the chapters of this volume, it becomes important to begin a discussion of the relevance of the group findings to the individual case. As is true for most aspects of cognitive and perceptual function in AD, the visual profile is characterized by heterogeneity. Our study of samples may indicate that most patients perform well on certain tests and poorly on others, but how well does this information describe what one is likely to see in an individual case?In order to address this question, this chapter summarizes some of the recent research on group differences in visual performance between patients with AD and healthy adults, focusing on studies that assessed a range of visual functions. Then, it examines the heterogeneity of performance in an attempt to identify demographic, neuropathological and other factors that are most salient to the visual profile of individual cases. Behavioral studies described here that use the term 'AD' were conducted with patients who had a diagnosis of probable or possible AD in the absence of neuropathological confirmation of the disease. Deficits in Basic Vision in Patients with ADThe prevalence of visual deficits is high in AD, with impairments found in a wide range of visual functions in a large sample of participants that we assessed [1]. This study included 77 patients with probable AD and 111 healthy control

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Facial frequency manipulation normalizes face discrimination in AD

Cited by 29 publications

References 9 publications

Face processing improvements in prosopagnosia: successes and failures over the last 50 years

Face processing improvements in prosopagnosia: successes and failures over the last 50 years

Characteristics of Visual Target Influence Detection of Change in Naturalistic Scenes in Alzheimer Disease

Heterogeneity of Visual Presentation in Alzheimer's Disease

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