Facial emotion recognition, face scan paths, and face perception in children with neurofibromatosis type 1.

Lewis, Amelia K.; Porter, Melanie; Williams, Tracey; Bzishvili, Samantha; North, Klaus; Payne, Jonathan M.

doi:10.1037/neu0000340

Cited by 15 publications

(22 citation statements)

References 52 publications

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“…Investigating the relationship between attention to faces and day‐to‐day social functioning in children with NF1 will also be an important focus for future research. There is increasing evidence to suggest that NF1 is associated with both face‐processing abnormalities and significantly poorer social outcomes compared with the general population . While the findings of the current study indicate preliminary support for a relationship between atypical face‐directed attention and ASD‐related behavioural difficulties, the associations between these variables in children with NF1 remain unclear and the psychological constructs driving the observed poor attention to faces are not known.…”

Section: Discussioncontrasting

confidence: 49%

“…Furthermore, by analysing the adjusted ‘mean dwell time per cent’, our results reflect attention allocated to faces within social scenes rather than time spent looking off‐screen, thereby accounting for elevated levels of ‘off‐task behaviour’ that might be expected owing to the attention deficits that are common in children with NF1 . These findings add to the growing body of research supporting face‐processing abnormalities in individuals with NF1 …”

Section: Discussionmentioning

confidence: 74%

“…However, there are some differences between behavioural features typically seen in ASD and those reported in NF1. For example, our previous eye‐tracking study reported normal face‐scan paths in children with NF1, including attention to the eye region . While too few studies exist to form firm conclusions, emerging findings also suggest that ASD features observed in NF1 are characterized by better eye contact than idiopathic ASD .…”

Section: Discussionmentioning

confidence: 93%

“…Face perception was examined using the Facial Recognition Test, which assessed identification and discrimination of unfamiliar human faces based on black‐and‐white photographs . Our examination and scoring procedures have been previously described …”

Section: Methodsmentioning

confidence: 99%

“…While eye gaze is not completely analogous to attention, evidence suggests that scan path analysis allows researchers to map the spatiotemporal locations of visual attention to develop a better understanding of how individuals analyse and perceive visual material . To date, only one study has used eye‐tracking technology to investigate face processing in children with NF1 and found that the amount of time spent viewing key individual facial features, such as the eyes, did not differ from a typically developing comparison group . Nevertheless, children with NF1 spent significantly less time viewing internal facial features overall than controls, suggesting the degree of visual attention they allocate to faces, at least when presented in isolation, is reduced.…”

mentioning

confidence: 99%

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Attention to faces in social context in children with neurofibromatosis type 1

Lewis

Porter

Williams

et al. 2018

Develop Med Child Neuro

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Attention to faces in social context in children with neurofibromatosis type 1

Lewis

Porter

Williams

et al. 2018

Develop Med Child Neuro

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A systematic review and meta‐analysis of intellectual, neuropsychological, and psychoeducational functioning in neurofibromatosis type 1

Crow

Janssen

Marshall

et al. 2022

American J of Med Genetics Pt A

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Neurofibromatosis Type 1 (NF1) is a common genetic disorder frequently associated with cognitive deficits. Despite cognitive deficits being a key feature of NF1, the profile of such impairments in NF1 has been shown to be heterogeneous. Thus, we sought to quantitatively synthesize the extant literature on cognitive functioning in NF1. A random-effects meta-analysis of cross-sectional studies was carried out comparing cognitive functioning of patients with NF1 to typically developing or unaffected sibling comparison subjects of all ages. Analyses included 50 articles (Total N NF1 = 1,522; M Age = 15.70 years, range = 0.52-69.60), yielding 460 effect sizes. Overall moderate deficits were observed [g = À0.64, 95% CI = (À0.69, À0.60)] wherein impairments differed at the level of cognitive domain. Deficits ranged from large [general intelligence: g = À0.95, 95% CI = (À1.12, À0.79)] to small [emotion: g = À0.37, 95% CI = (À0.63, À0.11)]. Moderation analyses revealed nonsignificant contributions of age, sex, educational attainment, and parental level of education to outcomes. These results illustrate that cognitive impairments are diffuse and salient across the lifespan in NF1. Taken together, these results further demonstrate efforts should be made to evaluate and address cognitive morbidity in patients with NF1 in conjunction with existing best practices.

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Social Function and Autism Spectrum Disorder in Children and Adults with Neurofibromatosis Type 1: a Systematic Review and Meta-Analysis

et al. 2018

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In light of the proliferation of recent research into social function in neurofibromatosis type 1 (NF1), a systematic review and meta-analysis is required to synthesise data and place findings within the context of a theoretical framework. This paper reviews findings from research into social function and autism spectrum disorder (ASD) in children and adults with NF1 and integrates these findings with the Socio-Cognitive Integration Abilities Model (SOCIAL). It also critically appraises links between social outcomes, internal and external factors moderating social functioning, cognitive domains implicated in social functioning, and underlying neural pathology in NF1. A systematic literature search conducted in MedLine (Ovid), PsycINFO (Ovid), Embase (Ovid), and PubMed electronic databases yielded 35 papers that met inclusion criteria for the systematic review. Out of these papers, 22 papers provided sufficient data for meta-analysis. Findings from this review and meta-analysis provide evidence that children and adults with NF1 exhibit significantly higher prevalence and severity of social dysfunction and ASD symptomatology. To date, very few studies have examined social cognition in NF1 but results indicate the presence of both perceptual and higher-level impairments in this population. The results of this review also provide support for age, gender, and comorbid ADHD as moderating factors for social outcomes in NF1. Suggestions for future research are offered to further our understanding of the social phenotype in NF1 and to facilitate the development of targeted interventions.

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Facial emotion recognition, face scan paths, and face perception in children with neurofibromatosis type 1.

Abstract: These results suggest that impairments in the perception, identification, and interpretation of information from faces are important aspects of the social-cognitive phenotype of NF1. (PsycINFO Database Record

Cited by 15 publications

References 52 publications

Attention to faces in social context in children with neurofibromatosis type 1

Attention to faces in social context in children with neurofibromatosis type 1

A systematic review and meta‐analysis of intellectual, neuropsychological, and psychoeducational functioning in neurofibromatosis type 1

Social Function and Autism Spectrum Disorder in Children and Adults with Neurofibromatosis Type 1: a Systematic Review and Meta-Analysis

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