Facial emotion perception in depression and bipolar disorder: A quantitative review

Kohler, Christian G.; Hoffman, L. Richard; Eastman, Lucas B.; Healey, Kristin M.; Moberg, Paul J.

doi:10.1016/j.psychres.2011.04.019

Cited by 196 publications

(171 citation statements)

References 53 publications

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“…51 Amygdala hyperactivity has been reported consistently in individuals with BD during facial emotion processing. 9,10,13,14 In children and adults with BD, VLPFC hypoactivity in response to emotional stimuli is also well documented. 12,13 Therefore, the reduced attention to eye regions that we observed in children with BD may be associated with amygdala and VLPFC dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] In both adults and children with BD, amygdala dysfunction during facial emotion processing is among the most replicated findings. [9][10][11][12][13][14][15] Given the associations between amygdala dysfunction and deficits in eye gaze, 16 a study of visual scan paths in individuals with BD is a logical extension of the neuroimaging literature on this illness. With regard to SMD, the neural dysfunction data are considerably more limited, although data do suggest both amygdala and parietal dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation

Kim

Arizpe²,

Rosen³

et al. 2013

J Psychiatry Neurosci

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IntroductionSevere mood disorders in children, specifically bipolar disorder (BD) and severe mood dysregulation (SMD), have recently received increased attention, as researchers and clin icians acknowledge the substantial impairment and treatment needs of these populations. The BD and SMD phenotypes differ in that BD is characterized by distinct episodes of mania (and, frequently, depression), whereas SMD is characterized by severe, chronic, impairing irritability.1 Importantly, however, the 2 phenotypes are similar in that both are severe pediatric mood disorders that share Background: Children with bipolar disorder (BD) or severe mood dysregulation (SMD) show behavioural and neural deficits during facial emotion processing. In those with other psychiatric disorders, such deficits have been associated with reduced attention to eye regions while looking at faces. Methods: We examined gaze fixation patterns during a facial emotion labelling task among children with pediatric BD and SMD and among healthy controls. Participants viewed facial expressions with varying emotions (anger, fear, sadness, happiness, neutral) and emotional levels (60%, 80%, 100%) and labelled emotional expressions. Results: Our study included 22 children with BD, 28 with SMD and 22 controls. Across all facial emotions, children with BD and SMD made more labelling errors than controls. Compared with controls, children with BD spent less time looking at eyes and made fewer eye fixations across emotional expressions. Gaze patterns in children with SMD tended to fall between those of children with BD and controls, although they did not differ significantly from either of these groups on most measures. Decreased fixations to eyes correlated with lower labelling accuracy in children with BD, but not in those with SMD or in controls. Limitations: Most children with BD were medicated, which precluded our ability to evaluate medication effects on gaze patterns. Conclusion: Facial emotion labelling deficits in children with BD are associated with impaired attention to eyes. Future research should examine whether impaired attention to eyes is associated with neural dysfunction. Eye gaze deficits in children with BD during facial emotion labelling may also have treatment implications. Finally, children with SMD exhibited decreased attention to eyes to a lesser extent than those with BD, and these equivocal findings are worthy of further study.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation

Kim

Arizpe²,

Rosen³

et al. 2013

J Psychiatry Neurosci

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“…Behavioral findings: Similar to adults with BD (Kohler et al 2011;Lembke and Ketter 2002), face emotion labeling deficits have been observed in children with BD (Guyer et al 2007;Rich et al 2006) and youth at familial risk for BD (Brotman et al 2008a, b). Youth with BD make more errors identifying emotions, compared to healthy controls (Guyer et al 2007;McClure et al 2005) or youth with anxiety and depression (Guyer et al 2007).…”

Section: Face Emotion Processingmentioning

confidence: 91%

“…Together, these difficulties in emotional processing may contribute to the social impairment commonly observed in BD, since the ability to read social cues and facial expressions is essential for adaptive social functioning. fMRI findings: Research examining the neural circuitry mediating face emotion processing in BD implicates dysfunction in the fronto-limbic-striatal network (for reviews, see Blond et al 2012;Chen et al 2011;Delvecchio et al 2012;Houenou et al 2011;Kohler et al 2011;Kupferschmidt and Zakzanis 2011;Pavuluri and Passarotti 2008;Strakowski et al 2012). Abnormalities in amygdala function during face emotion processing are observed consistently in both children (for a review, see Pavuluri and Passarotti 2008) and adults with BD (for a review, see Strakowski et al 2012).…”

Section: Face Emotion Processingmentioning

confidence: 99%

A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders

Tseng¹,

Leibenluft²,

Brotman³

2013

The Neurobiology of Childhood

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Emotional dysregulation is a core feature of pediatric mood and anxiety disorders. Emerging evidence suggests that these disorders are mediated by abnormalities in the functions and structures of the developing brain. This chapter reviews recent behavioral and functional magnetic resonance imaging (fMRI) research on pediatric mood and anxiety disorders, focusing on the neural mechanisms underlying these disorders. Throughout the chapter, we highlight the relationship between neural and behavioral findings, and potential novel treatments. The chapter concludes with directions for future research.

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“…Bipolar disorder (BD) is an affective disorder characterised by mood fluctuation and is associated with social, emotional and cognitive impairment 1,2,3 .…”

Section: Introductionmentioning

confidence: 99%

Emotional Processing, P50 Sensory Gating, and Social Functioning in Bipolar Disorder

et al. 2014

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Emotional processing has been reported to affect sensory gating as measured by the event-related potential known as P50. As both P50 and emotional processing are dysfunctional in bipolar disorder, we sought to investigate the impact that concurrent emotion processing has on sensory gating in this psychiatric population. P50 was recorded using a paired click paradigm. Peak-to-peak amplitudes for stimulus 1 (S1) and stimulus 2 (S2) were acquired during the presentation of disgust and neutral faces to young adults with bipolar disorder (N=19) and controls (N=20). Social functioning and quality of life self-reported measures were also obtained. The bipolar disorder group had significantly larger P50 amplitudes elicited by the S2-disgust response compared to controls, however no significant difference in overall P50 sensory gating was found between the groups. There were also no differences between groups in S1-disgust, nor in either of the neutral P50 amplitudes. The bipolar disorder group showed significant associations between sensory gating to disgust and measures of social functioning. Importantly, bipolar disorder showed impaired filtering of auditory information when paired to an emotionally salient image. Thus, it appears that patients with the greatest impairment in sensory gating also have the most difficulty to engage in social situations.

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Facial emotion perception in depression and bipolar disorder: A quantitative review

Cited by 196 publications

References 53 publications

Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation

Impaired fixation to eyes during facial emotion labelling in children with bipolar disorder or severe mood dysregulation

A Systems Neuroscience Approach to the Pathophysiology of Pediatric Mood and Anxiety Disorders

Emotional Processing, P50 Sensory Gating, and Social Functioning in Bipolar Disorder

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