Facial cytomegalovirus ulcers in transformed mycosis fungoides

Chai, Zi Teng; Oh, Choon Chiat

doi:10.1016/j.jdcr.2020.04.009

Cited by 1 publication

(2 citation statements)

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“…[2][3][4] Overall, the most common presentation of cutaneous CMV infection among immunocompromised patients including hematopoietic stem cell transplantation recipients is anogenital ulcers, but extensive or disseminated cutaneous CMV infection following radiation therapy has also been described in patients with cutaneous T-cell lymphoma. [12][13] Nevertheless, CMV infection presenting as cellulitis has scarcely been reported. This disease entity is probably under-recognized because it relies largely on histopathological examination.…”

Section: Discussionmentioning

confidence: 99%

“…While grouped vesicles in a dermatomal pattern suggest varicella zoster virus reactivation, cutaneous manifestations of CMV infection are variable and include ulcers, maculopapules, plaques, vesicles and nodules (Table 1). [2–4] Overall, the most common presentation of cutaneous CMV infection among immunocompromised patients including hematopoietic stem cell transplantation recipients is anogenital ulcers, but extensive or disseminated cutaneous CMV infection following radiation therapy has also been described in patients with cutaneous T-cell lymphoma [12–13] . Nevertheless, CMV infection presenting as cellulitis has scarcely been reported.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous presentation of disseminated cytomegalovirus infection in a non-transplant patient with hematological malignancy

Liu

Kuo

et al. 2022

Medicine

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Rationale: Cytomegalovirus (CMV) disease is relatively uncommon in nontransplant hematological patients. Moreover, cutaneous manifestations of CMV diseases have scarcely been reported and are probably under-recognized.Patient concerns: We describe a patient with large B-cell lymphoma who developed a band-form, erythematous lesion over his left abdomen soon after the second course of rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone chemotherapy.Diagnoses: The lesion was initially mistaken for bacterial cellulitis or herpes zoster and was histologically confirmed as cutaneous CMV infection. Subsequent work-up also detected CMV viremia and the presence of CMV meningoencephalitis. Interventions:The patient was treated with ganciclovir plus CMV immune globulin followed by foscarnet.Outcomes: Although the patient's cutaneous lesion resolved, his cognitive impairment did not recover, and he developed a fatal multi-organ failure 1 month later.Lessons: Cutaneous CMV disease can herald multisystem involvement and an unfavorable prognosis in immunocompromised hosts. It should be ruled out with biopsy in patients with hematological malignancy who have cutaneous lesions refractory to antibacterial therapy.

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