Facial Cosmetic Filler Injections as Possible Target for Systemic Sarcoidosis in Patients Treated with Interferon for Chronic Hepatitis C: Two Cases

Descamps, V.; Landry, Jennifer; Françès, Camille; Marinho, E.; Ratziu, Vlad; Chosidow, Olivier

doi:10.1159/000128281

Cited by 54 publications

(21 citation statements)

References 34 publications

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“…Skin lesions are usually erythematous papules or nodules arising at the sites of drug injection, tattoos or old scars (2). Cases occurring at the sites of injection of resorbable or pennanent facial fillers have also been recently reported (10).…”

Section: Discussionmentioning

confidence: 99%

HLA Typing in an IFN- -induced Scar Sarcoidosis: Possible Pathogenetic and Clinical Implications

Zampino¹,

Corazza²,

Borghi³

et al. 2009

Acta Derm Venerol

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SinSarcoidosis as a complication ofinterferon (IFN) administration was first described in 1987 in a patient with renal cancer (I). Since then, more than 50 cases of pulmonary and/or cxtra-puhnonary sarcoidosis. mainly occurring in middle-aged women, have been correlated with IFN-a therapy, sometimes associated with ribavirin, in patients with chronic viral hepatitis C (2.3). Several lines of evidence suggest that HLA class I and class II alíeles may be considered possible markers for susceptibility, clinical behaviour and prognosis of sarcoidosis (4, 5).We report here a case of scar sarcoidosis that occurred one month after completion of a course of pegylatedlFN-a therapy for chronic hepatitis C virus (HC V) infection. HLAtyping was perfomied to evaluate the potential role of an immunogenetic predisposition factor. CASE REPORTA 59-year-old woman was evaluated for a paitiless nodule that had developed slowly on her right foreami over the previous 2 months. Physical examination revealed a well-demarcated, hard, .subcutaneous nodule. 4 cm in diameter, underlying a linear posttraiimalic scar acquired during childhood (Fig. I ). The patient had previously undergone a 24-week treatment for active chronic HCV genotype 2a/2c, consisting of 180 |.ig of PEG-lFN-a, administered subcutaneously once weekly, and 800 mg/day of oral ribavirin. This treatment had had a successful outcome, leading to an undetectahle viral load and an improvement in the results of liver enzyme tests by the tburth week of therapy. The treatment was completed one month prior to the appearance of the nodule.The nodule was surgically removed and the specimen was stained with haematoxylin and eosin. Histopathologiea! examination revealed the presence of Langhans giant ceils and sarcoidal-type, non-necrotizing, round, epithelioid granulomas in both dermis and hypodermis. cireumseribed by peripheral fibrosis (Fig. 2).The patient showed neither pulmonary symptoms nor other signs of systemic sarcoidat involvement. Chest X-ray and angiotensinFig. I. Subcutaneous nodule underlying a linear post-traumatic scar on the right forearm.

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Section: Discussionmentioning

confidence: 99%

HLA Typing in an IFN- -induced Scar Sarcoidosis: Possible Pathogenetic and Clinical Implications

Zampino¹,

Corazza²,

Borghi³

et al. 2009

Acta Derm Venerol

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“…We find several case reports describing granulomatous inflammation and cutaneous sarcoidosis after injection of silicone for cosmetic purposes (21)(22)(23)(24)(25). Remission of assumed sarcoidosis after removal of silicone breast implants has also been described (26).…”

Section: Discussionmentioning

confidence: 99%

En kvinne i 30-årene med feber av ukjent årsak

Bø¹,

Erikson²,

Lyngøy³

et al. 2017

Tidsskriftet

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“…In our review, we found that in 29% of cases skin sarcoidosis was triggered by a classical KP (table 1). Typical triggers of the KP in sarcoidosis are foreign material present in tattoos [19,20,21], synthetic fillers used for cosmetic procedures [22], or talc injected in the context of intravenous drug abuse [23,24]. Scars are also a typical trigger of KP and sarcoidosis [25,26], although most of the time foreign particles are undetectable in cutaneous biopsies, namely in 51 (78%) of 65 patients with scar sarcoidosis [25].…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Interferon-Alpha-Induced Sarcoidosis Koebnerized along Venous Drainage Lines: New Pathogenic Insights and Review of the Literature of Interferon-Induced Sarcoidosis

Buss¹,

Cattin

Spring

et al. 2013

Dermatology

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Sarcoidosis is a systemic granulomatous disorder of unknown origin commonly affecting the lung, the lymphoid system and the skin. We report here two cases of cutaneous sarcoidosis in two former intravenous drug users following interferon (IFN)-α and ribavirin therapy for chronic hepatitis C. Both patients developed skin sarcoidosis along venous drainage lines of both forearms, coinciding with the areas of prior drug injections. The unique distribution of the skin lesions suggests that tissue damage induced by repeated percutaneous drug injections represents a trigger for the local skin manifestation of sarcoidosis. Interestingly, skin damage was recently found to induce the local expression IFN-α, a well-known trigger of sarcoidosis in predisposed individuals. Here we review the literature on sarcoidosis elicited in the context of IFN-α therapy and propose a new link between the endogenous expression of IFN-α and the induction of disease manifestations in injured skin.

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Facial Cosmetic Filler Injections as Possible Target for Systemic Sarcoidosis in Patients Treated with Interferon for Chronic Hepatitis C: Two Cases

Cited by 54 publications

References 34 publications

HLA Typing in an IFN- -induced Scar Sarcoidosis: Possible Pathogenetic and Clinical Implications

HLA Typing in an IFN- -induced Scar Sarcoidosis: Possible Pathogenetic and Clinical Implications

En kvinne i 30-årene med feber av ukjent årsak

Two Cases of Interferon-Alpha-Induced Sarcoidosis Koebnerized along Venous Drainage Lines: New Pathogenic Insights and Review of the Literature of Interferon-Induced Sarcoidosis

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