Facial calcinosis cutis in a patient with systemic lupus erythematosus: A case report of tissue injury owing to photosensitivity as the cause of dystrophic calcification

López, Ana M.; Grossman, Marc E.

doi:10.1016/j.jdcr.2017.06.018

Cited by 8 publications

(6 citation statements)

References 13 publications

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“…Calcinotic lesions in SLE patients characteristically involve interphalangeal joints, forearms, elbows, buttocks, peri-auricular area, and tissue underneath cutaneous lupus lesions [ 91 , 92 , 93 ]. Facial calcinosis cutis has occasionally been described in SLE patients, even if it remains uncommon in all connective tissue disorders [ 94 , 95 ]. Calcinosis cutis is considered a late-stage complication, occurring on average 21.5 years after SLE onset [ 14 ].…”

Section: Calcinosis Cutis and Systemic Lupus Erythematosusmentioning

confidence: 99%

Calcinosis Cutis and Calciphylaxis in Autoimmune Connective Tissue Diseases

et al. 2023

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Calcinosis represents a severe complication of several autoimmune disorders. Soft-tissue calcifications have been classified into five major types: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis. Autoimmune diseases are usually associated with dystrophic calcifications, including calcinosis cutis, occurring in damaged or devitalized tissues in the presence of normal serum levels of calcium and phosphate. In particular, calcinosis cutis has been described in dermatomyositis, polymyositis, juvenile dermatomyositis, systemic sclerosis, systemic lupus erythematosus, primary Sjögren’s syndrome, overlap syndrome, mixed connective tissue disease, and rheumatoid arthritis. Calciphylaxis, a severe and life-threatening syndrome presenting with vascular calcifications and thrombosis, has also been associated with some autoimmune conditions. Due to the potentially disabling character of calcinosis cutis and calciphylaxis, physicians’ awareness about the clinical presentation and management of these diseases should be increased to select the most appropriate treatment option and avoid long-term complications. In this review, we aim to analyze the clinical features of calcinosis cutis and calciphylaxis associated with autoimmune diseases, and the main treatment strategies evaluated up to now for treating this potentially disabling disease.

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Section: Calcinosis Cutis and Systemic Lupus Erythematosusmentioning

confidence: 99%

Calcinosis Cutis and Calciphylaxis in Autoimmune Connective Tissue Diseases

et al. 2023

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“… 7 There is a report of a young woman with facial calcinosis in the setting of uncontrolled SLE, wherein her calcinosis was limited to the preauricular area. 8 In addition to preauricular calcinosis cutis, there have been several reports of calcinosis occurring on the skin overlying the mandible; however these were associated with underlying connective tissue disease. 9 , 10 To our knowledge, there have been no reported cases of calcinosis cutis of the nasal dorsum, nor any cases of idiopathic disease arising in the nose.…”

Section: Discussionmentioning

confidence: 99%

Calcinosis Cutis of the Nasal Dorsum

Marsh

Miyake

Alamiri

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Summary: Calcinosis cutis is a common dermatological problem in patients with systemic sclerosis, dermatomyositis, and systemic lupus erythematous; however, it is rare to occur outside of these diseases. It represents a multidisciplinary problem that involves primary care physicians, dermatologists, and surgeons. The pathophysiology is defined by deposition of calcium salts in the subcutaneous tissue as hydroxyapatite, but the underlying mechanism has yet to be determined. The most common locations of lesions are the scalp, scrotum, extremities, and joints. Rarely does calcinosis cutis occur on the face. We present a unique case of idiopathic calcinosis cutis that occurred in a healthy patient with normal serum calcium and phosphate levels on the nasal dorsum, which was managed surgically. The histology of the calcinosis showed normal morphology, dominated by large deposits of calcium and normal surrounding tissues. This case represents a rare but clinically relevant presentation of idiopathic calcinosis cutis in an otherwise healthy individual.

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“…To date, there are approximately 45 documented cases of cutaneous cutis occurring in SLE, and no randomized controlled trials elevating the efficacy of existing and emerging therapies. While not universally efficacious, oral therapies including diltiazem, colchicine, and minocycline are often used as initial agents in patients with generalized, dystrophic calcinosis given their relative safety [1,2,4,5]. Diltiazem, when used at high doses (2-4 mg/kg/day), inhibits intracellular calcium absorption in damaged tissue [4].…”

Section: Discussionmentioning

confidence: 99%

“…While common in connective tissue diseases, specifically dermatomyositis, and scleroderma, calcinosis cutis less frequently occurs as a complication of systemic lupus erythematosus (SLE) [ 2 - 4 ]. While the pathophysiology is still poorly understood, calcinosis cutis can be divided into five subtypes depending on mechanism of action: dystrophic, metastatic, idiopathic, iatrogenic, and calciphylaxis [ 1 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Dystrophic Calcinosis Cutis in Systemic Lupus Erythematosus

Achebe

Mbachi

Asotibe

et al. 2020

Cureus

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Calcinosis cutis is a disorder of pathologic calcium deposition in the cutaneous and subcutaneous layers of skin. While common in dermatomyositis and scleroderma, calcinosis cutis less frequently occurs in systemic lupus erythematosus (SLE) and is infrequently described in literature. In this report, we discuss the case of a 36-year-old patient with SLE, presenting with vascular compromise, ulceration, and superimposed infection of her left hand as a consequence of severe calcinosis cutis. This report includes a review of the current literature, and highlights the importance of early detection and intervention in preventing disease complications.

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Facial calcinosis cutis in a patient with systemic lupus erythematosus: A case report of tissue injury owing to photosensitivity as the cause of dystrophic calcification

Cited by 8 publications

References 13 publications

Calcinosis Cutis and Calciphylaxis in Autoimmune Connective Tissue Diseases

Calcinosis Cutis and Calciphylaxis in Autoimmune Connective Tissue Diseases

Calcinosis Cutis of the Nasal Dorsum

Dystrophic Calcinosis Cutis in Systemic Lupus Erythematosus

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