Facial basal cell carcinomas treated with hypo-fractionated radiotherapy: A retrospective analysis in 117 elderly patients

Pelissero, Antonio; Russi, Elvio; Melano, Antonella; Fillini, C.; Vigna‐Taglianti, Riccardo; Settineri, Nicola; Lucio, Francesco; Girolomoni, Giampiero; Pergolizzi, Stefano

doi:10.1016/j.jaad.2015.03.030

Cited by 13 publications

(13 citation statements)

References 6 publications

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“…Patients with many mild comorbidities or several severe comorbidities can have a poor treatment outcome even though they may otherwise have good KPS. Data observed in our patients seem to confirm the feasibility of curative treatment in patients with high Charlson score value such as observed in other articles (14)(15)(16)(17)(18)(19). In fact, our patients tolerated the treatment well although they had many illnesses with a median CCI score of 6.5.…”

Section: Discussionsupporting

confidence: 90%

Very Elderly (>80 Years), Frail Patients with Muscle-invasive Bladder Cancer and Comorbidities: Is Curative Irradiation Feasible?

Santacaterina

Platania

Palazzolo

et al. 2015

Tumori

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Section: Discussionsupporting

confidence: 90%

Very Elderly (>80 Years), Frail Patients with Muscle-invasive Bladder Cancer and Comorbidities: Is Curative Irradiation Feasible?

Santacaterina

Platania

Palazzolo

et al. 2015

Tumori

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“…22 Older age has been identified as a risk factor for refusing surgery in breast cancer patients. 51 Most studies on primary RT in elderly patients assessed the effectiveness of treatment schedules that were less intensive than traditional schemes, such as hypofractionated RT (weekly irradiation as opposed to daily fractions) and found that hypofractionated RT was effective and well-tolerated in elderly patients 38,[52][53][54][55] , as summarized in Table 2. However, these results should be handled with care as the studies suffer from the lack of control groups and short follow-up.…”

Section: Effect Of Age On Treatment Outcomes Of Common Treatment Modamentioning

confidence: 99%

Treatment of keratinocyte carcinoma in elderly patients – a review of the current literature

Leus

Frie

Haisma

et al. 2020

Acad Dermatol Venereol

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A large percentage of the patients with keratinocyte carcinoma (KC, formerly known as non‐melanoma skin cancer) is of advanced age and often too frail for standard therapies. However, no specific treatment recommendations are given for this population. This review aimed to give an overview of the current literature on the best practice for the treatment of elderly patients with KC. A literature search was performed in MEDLINE, using ‘keratinocyte carcinoma’, ‘elderly’, ‘treatment’ and various synonyms. Case reports, reviews, comments, non‐English literature and studies with a sample size <15 were excluded. After selection, a total of 47 studies were reviewed. Two types of studies were identified, focusing on (I) the effect of age on treatment outcomes and (II) alternative treatment schedules for elderly patients. Studies on surgery, the gold standard, describe larger lesions and defect size in the elderly population. Recurrence rate, complication rate and disease‐specific survival were not affected by age. Depending on the expected morbidity of a suggested (re‐)excision and patient preferences, a conservative watchful waiting policy can be agreed upon as a shared decision. Other common treatment modalities, such as adjuvant radiotherapy, photodynamic therapy and systemic therapy for basal cell carcinoma (BCC), show comparable results in the elderly and younger population. Alternative treatment schedules for elderly patients include primary hypofractionated radiotherapy, which seems effective and well‐tolerated, although research is limited to case series. Additionally, localized and topical treatments seem safe and effective especially for low‐risk tumours. Data are lacking on the efficacy of systemic therapies of metastatic KC in elderly patients. Efficacy of most treatments (with the exception of photodynamic therapy) is not dependent on age. There is need for more research on the efficacy of adjusted treatment modalities, such as hypofractionated radiotherapy and palliative or curative systemic treatment.

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“…The best cosmetic and functional result can be obtained with radiotherapy in cases of SCC of the lip, nose, and ear [ 3 ]. Additionally, long-term results of SCC treated with radiotherapy are similar to those of other treatment modalities [ 9 10 11 12 ]. Using SBRT we obtained a long-term and complete clinical remission, preserving anatomical functionality.…”

Section: Discussionmentioning

confidence: 89%

A case report of a patient with squamous cell carcinoma of the face irradiated using a stereotactic technique

2015

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External beam radiotherapy can be used to treat cutaneous squamous cell carcinomas (SCC). Acute skin toxicity is the most common adverse event. In this case study we report on an elderly patient with nasal root cutaneous SCC treated with stereotactic technique using a dedicated linear accelerator (CyberKnife system). Grade 3 skin toxicity was observed but it was resolved after 6 weeks. The use of stereotactic radiotherapy permitted a clinical remission of SCC with good cosmetic results.

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Facial basal cell carcinomas treated with hypo-fractionated radiotherapy: A retrospective analysis in 117 elderly patients

Cited by 13 publications

References 6 publications

Very Elderly (>80 Years), Frail Patients with Muscle-invasive Bladder Cancer and Comorbidities: Is Curative Irradiation Feasible?

Very Elderly (>80 Years), Frail Patients with Muscle-invasive Bladder Cancer and Comorbidities: Is Curative Irradiation Feasible?

Treatment of keratinocyte carcinoma in elderly patients – a review of the current literature

A case report of a patient with squamous cell carcinoma of the face irradiated using a stereotactic technique

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