Facial affect recognition in symptomatically remitted patients with schizophrenia and bipolar disorder

Yalcin-Siedentopf, Nursen; Hoertnagl, Christine M.; Biedermann, Falko; Baumgartner, Susanne E.; Deisenhammer, E; Hausmann, Armand; Kaufmann, Alexandra; Kemmler, Georg; Mühlbacher, Moritz; Rauch, Anna-Sophia; Fleischhacker, W. Wolfgang; Hofer, Alex

doi:10.1016/j.schres.2013.11.024

Cited by 42 publications

(35 citation statements)

References 49 publications

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“…We do not know whether the results of our study are generalizable to patients in earlier stages of illness or with a less severe disorder. However, facial emotion recognition deficits are observed in first-episode patients as well ( Bediou et al, 2007 , Edwards et al, 2001 ) and there is evidence that social cognitive deficits are relatively stable across phases of illness ( Comparelli et al, 2013 , Green et al, 2012 , Vohs et al, 2014 , Yalcin-Siedentopf et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Specificity of facial emotion recognition impairments in patients with multi-episode schizophrenia

Barkhof

Sonneville

Meijer

et al. 2015

Schizophrenia Research: Cognition

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BackgroundPatients with schizophrenia show impairments in social information processing, such as recognising facial emotions and face identity.GoalThe aim of this study was to explore whether these impairments represent specific deficits or are part of a more general cognitive dysfunction.MethodForty-two patients with schizophrenia and 42 matched controls were compared on facial emotion and face identity recognition versus (non-social) abstract pattern recognition, using three tasks of the Amsterdam Neuropsychological Tasks (ANT) program.ResultsPatients were slower than controls in social information processing as well as in (non-social) abstract pattern recognition. Patients were also less accurate than controls in processing social information, but not in recognition of abstract patterns. Differences between patients and controls were most substantial for facial emotion recognition compared to both face identity recognition (speed) and non-social pattern recognition (speed and accuracy). Finally, differences between patients and controls were largest for the recognition of negative emotions.ConclusionCompared to controls patients with schizophrenia displayed more difficulties in processing of social information compared to non-social information. These results support the hypothesis that facial emotion recognition impairment is a relatively distinct entity within the domain of cognitive dysfunction in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Specificity of facial emotion recognition impairments in patients with multi-episode schizophrenia

Barkhof

Sonneville

Meijer

et al. 2015

Schizophrenia Research: Cognition

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“…Individuals with schizophrenia exhibit marked and disproportional impairments in social cognition (Lee et al, 2013; Savla et al, 2013) which are strongly associated with their community functioning (Fett et al, 2011). Social cognition is considered to be a promising endophenotype for schizophrenia because impairments are evident early in illness, present during symptomatic remission, heritable, and present in milder form in first degree relatives (Comparelli et al, 2013; Green et al, 2015, 2012a; Lavoie et al, 2013; Yalcin-Siedentopf et al, 2014). However, it is unclear whether social cognitive impairment is stable over time, or if impairment worsens as a function of illness chronicity.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal stability of social cognition in schizophrenia: A 5-year follow-up of social perception and emotion processing

McCleery

Lee

Fiske³

et al. 2016

Schizophrenia Research

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Background Individuals with schizophrenia exhibit marked and disproportional impairment in social cognition, which is associated with their level of community functioning. However, it is unclear whether social cognitive impairment is stable over time, or if impairment worsens as a function of illness chronicity. Moreover, little is known about the longitudinal associations between social cognition and community functioning. Method Forty-one outpatients with schizophrenia completed tests of emotion processing (Mayer-Salovey-Caruso Emotional Intelligence Test, MSCEIT) and social perception (Relationships Across Domains, RAD) at baseline and approximately five years later. Stability of performance was assessed using paired t-tests and correlations. Longitudinal associations between social cognition and community functioning (Role Functioning Scale, RFS) were assessed using cross-lagged panel correlation analysis. Results Performance on the two social cognition tasks were stable over follow-up. There were no significant mean differences between assessment points [p's≥0.20, Cohen's d's≤|0.20|], and baseline performance was highly correlated with performance at follow-up [ρ's≥0.70, ICC≥0.83, p's<0.001]. The contemporaneous association between social cognition and community functioning was moderately large at follow-up [ρ=0.49, p=.002]. However, baseline social cognition did not show a significant longitudinal influence on follow-up community functioning [z=0.31, p=0.76]. Conclusions These data support trait-like stability of selected areas of social cognition in schizophrenia. Cross-lagged correlations did not reveal a significant unidirectional influence of baseline social cognition on community functioning five years later. However, consistent with the larger literature, a moderately large cross-sectional association between social cognition and community functioning was observed. Based on stability and cross-sectional associations, these results suggest that social cognition might have short-term implications for functional outcome rather than long-term consequences.

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“…Despite such evidence, little is still known about PM in symptomatically remitted patients with schizophrenia, although prior studies have shown the persistence of neuropsychological deficits in some cognitive domains including theory of mind (Mo et al, 2008 ) and emotional reaction (Yalcin-Siedentopf et al, 2014 ) in those patients. To address this question, we combined an event-based PM paradigm with ERPs in 20 symptomatically remitted patients with schizophrenia and 20 healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Event-related brain potential correlates of prospective memory in symptomatically remitted male patients with schizophrenia

Chen

Zhang

Ding

et al. 2015

Front. Behav. Neurosci.

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Prospective memory (PM) refers to the ability to remember to perform intended actions in the future. Although PM deficits are a prominent impairment in schizophrenia, little is still known about the nature of PM in symptomatically remitted patients with schizophrenia. To address this issue, event-related brain potentials (ERPs) were recorded from 20 symptomatically remitted patients with schizophrenia and 20 healthy controls during an event-based PM paradigm. Behavioral results showed that symptomatically remitted patients with schizophrenia performed poorly on the PM task compared with healthy controls. On the neural level, the N300, a component of the ERPs related to PM cue detection, was reliable across these two groups, suggesting a degree of functional recovery of processes supporting cue detection in patients with symptomatically remitted schizophrenia. By contrast, the amplitude of the prospective positivity, a component of the ERPs related to PM intention retrieval, was significantly attenuated in symptomatically remitted schizophrenia patients relative to healthy controls. Furthermore, a significant positive correlation between the amplitude of the prospective positivity and accuracy on the PM task was found in those patients, indicating that patients’ poor performance on this task may result from the failure to recover PM cue-induced intention from memory. These results provide evidence for the existence of altered PM processing in patients with symptomatically remitted schizophrenia, which is characterized by a selective deficit in retrospective component (intention retrieval) of PM. Therefore, these findings shed new light on the neurophysiological processes underlying PM in schizophrenia patients during clinical remission.

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Facial affect recognition in symptomatically remitted patients with schizophrenia and bipolar disorder

Cited by 42 publications

References 49 publications

Specificity of facial emotion recognition impairments in patients with multi-episode schizophrenia

Specificity of facial emotion recognition impairments in patients with multi-episode schizophrenia

Longitudinal stability of social cognition in schizophrenia: A 5-year follow-up of social perception and emotion processing

Event-related brain potential correlates of prospective memory in symptomatically remitted male patients with schizophrenia

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