Face transplant: long-term follow-up and results of a prospective open study

Lantieri, Laurent; Grimbert, Philippe; Ortonne, Nicolas; Suberbielle, Caroline; Bories, Dominique; Gil-Vernet, S.; Lemogne, Cédric; Bellivier, Frank; Lefaucheur, Jean Pascal; Schaffer, Nathaniel E.; Martin, Frédéric; Meningaud, Jean Paul; Wolkenstein, Pierre; Hivelin, Mikaël

doi:10.1016/s0140-6736(16)31138-2

Cited by 128 publications

(122 citation statements)

References 29 publications

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“…Multi‐variate and multiscale data‐based and/or physics‐based statistical models of biological tissues built from the results of machine learning (ie, meta‐models) could then replace computationally expensive physics‐based finite element models and be used to predict a variety of scenarios and outcomes. For example, one could ask: What should be the optimal locations/lengths/types of surgical skin sutures in complex reconstructive surgery procedures such as face transplant and what might be the effect of ethnicity and age? The answers to these questions will depend on many factors and hence are likely to be statistical distributions rather than single deterministic values.…”

Section: Future Developmentsmentioning

confidence: 99%

How stiff is skin?

Graham

McConnell

Limbert

et al. 2019

Experimental Dermatology

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The measurement of the mechanical properties of skin (such as stiffness, extensibility and strength) is a key step in characterisation of both dermal ageing and disease mechanisms and in the assessment of tissue‐engineered skin replacements. However, the biomechanical terminology and plethora of mathematical analysis approaches can be daunting to those outside the field. As a consequence, mechanical studies are often inaccessible to a significant proportion of the intended audience. Furthermore, devices for the measurement of skin function in vivo generate relative values rather than formal mechanical measures, therefore limiting the ability to compare studies. In this viewpoint essay, we discuss key biomechanical concepts and the influence of technical and biological factors (including the nature of the testing apparatus, length scale, donor age and anatomical site) on measured mechanical properties such as stiffness. Having discussed the current state‐of‐the‐art in macro‐mechanical and micromechanical measuring techniques and in mathematical and computational modelling methods, we then make suggestions as to how these approaches, in combination with 3D X‐ray imaging and mechanics methods, may be adopted into a single strategy to characterise the mechanical behaviour of skin.

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Section: Future Developmentsmentioning

confidence: 99%

How stiff is skin?

Graham

McConnell

Limbert

et al. 2019

Experimental Dermatology

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“…However, as the numbers of patients have increased, more difficulties and challenges have also been encountered. More refinements and better results have now been achieved in all new cases, especially in centers with higher levels of experience (Giatsidis, Sinha, & Pomahac, ; Khalifian et al, ; Lantieri et al, ; Petruzzo et al, ; Pomahac et al, ; Siemionow, Gharb, & Rampazzo, ).…”

Section: Introductionmentioning

confidence: 99%

Face allotransplantation for various types of facial disfigurements: A series of five cases

Özkan

Ubur

et al. 2017

Microsurgery

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“…However, since the effect of the psychiatric and psychological help was not quantified, the question remains whether a couple in ordinary circumstances, provided with similar professional support, would expect to improve more than this couple. Our results may also underline the importance of good psychosocial support before the transplantation (Lantieri et al ., ) and the need for family involvement and support by the medical team after the transplantation (Lemmens et al ., ). Despite the high dyadic adjustment, the marital depth of the partner decreased at three years follow‐up.…”

Section: Discussionmentioning

confidence: 99%

“…The partner in our study has not reported any psychologically distress from the transplantation . It is likely that the good preoperative psychosocial stability of both partners, their high motivation and compliance with the treatment and rehabilitation programme and the good surgical outcome have contributed to these results (Diaz-Siso and Rodriguez, 2016;Lantieri et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Another four patients showed large improvements in their quality of life, linked to the improvement in their facial function and appearance, one year after face transplantation (Lantieri et al, 2011). However, long-term improvements in social integration and quality of life were highly variable among six face transplant patients and depended on preexisting psychiatric comorbidities and social support (Lantieri et al, 2016). Finally, depression and verbal abuse decreased, quality of life and societal reintegration of a legally blind, female patient improved up to three years after transplantation (Coffman et al, 2010;Coffman and Siemionow, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Long‐term psychosocial outcomes after face transplantation: a patient's and a partner's perspective

Lemmens

Hendrickx

Poppe

et al. 2017

Journal of Family Therapy

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To date, psychosocial outcomes after face transplantation are promising, although the impact on family relationships is less well investigated. Depressive and anxiety symptoms, resilience, spousal support, dyadic adjustment, family functioning of a patient and the partner were assessed before, and two, three and four years after the face transplantation. Most psychological, marital and family scores of both partners remained within a normative and healthy range at follow‐up. Resilience, illness cognitions, physical quality of life, and family affective responsiveness and communication of the patient further improved, whereas the partner reported higher resilience and dyadic consensus at four years after transplantation. The results of this study point to positive long‐term psychosocial outcomes of a blind patient and his partner after face transplantation. Practitioner points Psychological health of patient and partner remains good after face transplantation Marital and family functioning remains stable after face transplantation and may even improve Face transplantation may strengthen the resilience of the patient and the partner

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Face transplant: long-term follow-up and results of a prospective open study

Cited by 128 publications

References 29 publications

How stiff is skin?

How stiff is skin?

Face allotransplantation for various types of facial disfigurements: A series of five cases

Long‐term psychosocial outcomes after face transplantation: a patient's and a partner's perspective

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