Fabrication of vertically aligned PEDOT nanotube arrays on microelectrodes to interface neurons

Chen, Hailan; Tian, Guang-zhao; Yan, Hao; Yang, Songxin; Kim, Dong Hwan

doi:10.1016/j.electacta.2021.139583

Cited by 7 publications

(7 citation statements)

References 46 publications

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“…The PC12 cell has been widely used as a model system to study neuronal differentiation due to its differentiation behavior toward NGF Figure A shows the fluorescence images of PC12 cells cultured on ITO, MWCNTs/Dex-PPy/PGlu/PSS-PLys, and MWCNTs/Dex-PPy/PGlu/PSS-PLys-NGF functional coatings for 4 days.…”

Section: Resultsmentioning

confidence: 99%

“…The PC12 cell has been widely used as a model system to study neuronal differentiation due to its differentiation behavior toward NGF. 26 Figure 7A shows the fluorescence images of PC12 cells cultured on ITO, MWCNTs/Dex-PPy/ PGlu/PSS-PLys, and MWCNTs/Dex-PPy/PGlu/PSS-PLys-NGF functional coatings for 4 days. Most cells cultured on ITO glass exhibited a spherical shape with little or no neurite sprouting, while cells grown on both MWCNTs/Dex-PPy/ PGlu/PSS-PLys and MWCNTs/Dex-PPy/PGlu/PSS-PLys-NGF functional coatings exhibited significantly improved neurite outgrowth and neurite elongation.…”

Section: Biosafety and Anti-inflammatorymentioning

confidence: 99%

“…Conducting polymers (CPs), such as polypyrrole (PPy) and poly(3,4-ethylenedioxythiophene) (PEDOT), are regarded as promising candidates for neural engineering due to their excellent conductivity, biocompatibility, stability, and capabilities to be tailored into various nanostructures on microscale electrodes. , Increased electrode sensitivity and selectivity have been observed from CP-modified neural electrodes via in vivo and in vitro studies. , In our previous studies, significantly lower interfacial impedance, higher charge transfer capability, increased electrochemical stability, and better cell-electrode integration have been obtained from electrodes modified with nanostructured coatings consisting of conductive polymers and/or carbon nanotubes (CNTs). − Besides, anti-inflammatory drugs, nerve growth factor (NGF), proteins, enzymes, DNA, peptides, and other bioactive molecules can be simply incorporated into or linked to the conductive polymer films to create new biological systems with desired functions …”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Presentation of Dexamethasone and Nerve Growth Factor via Layered Carbon Nanotubes and Polypyrrole to Interface Neural Cells

Tian,

Yang,

Chen

et al. 2023

ACS Biomater. Sci. Eng.

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The implantation of neural electrodes usually induces acute and chronic inflammation, which can result in the formation of glial scars encapsulating the implanted electrodes and the loss of neurons near the active electrode sites. Local presentation of anti-inflammatory drugs or neural protective factors has been evidenced as an effective strategy to modulate inflammatory responses and promote electrode–neuron integration. Here, a novel delivery system for the simultaneous presentation of both anti-inflammatory drugs (dexamethasone, Dex) and nerve-growth-promoting factors (nerve growth factor, NGF) from the electrode sites was developed via layer-structured carbon nanotubes and conductive polymers. The modified electrodes exhibited higher charge storage capacitance and lower electrochemical impedance compared to unmodified electrodes and electrodes coated with polypyrrole/Dex. Dex released from the functional coating under controlled electrochemical stimulation was able to inhibit the lipopolysaccharide-induced secretion or mRNA transcription of inflammatory cytokines, including nitric oxide, TNF-α, and IL-6 in RAW264.7 cells, and control the activation of cultured astrocytes. In addition, the functional coatings did not show a toxic effect on PC12 cells and primary neural cells but exhibited promoted activities on the adhesion, growth, and neurite extension of neural cells.

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Section: Resultsmentioning

confidence: 99%

Section: Biosafety and Anti-inflammatorymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous Presentation of Dexamethasone and Nerve Growth Factor via Layered Carbon Nanotubes and Polypyrrole to Interface Neural Cells

Tian,

Yang,

Chen

et al. 2023

ACS Biomater. Sci. Eng.

Self Cite

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“…Michigan arrays were recognized as ideal for the in situ embedding of integrated electrodes and large-channel counting probes to record from various cortical layers were subsequently constructed using them (Figure c). , Current advances include improved biocompatibility and enhanced integration. To ensure that the probe has the potential for long-term high-definition recording in vivo, the original flexible silicon wafer was replaced with a polymer material matrix, and the electrode interface was coated with a semiconducting polymer to retain low impedance. − Chung et al fabricated a multihandled polyimide electrode array to form a modular implantable device for multidepth recordings in the rat brain cortex . Each handle had 16 channels, with PEDOT covering the Pt electrodes.…”

Section: Applications and Devicesmentioning

confidence: 99%

Soft Fiber Electronics Based on Semiconducting Polymer

et al. 2023

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Fibers, originating from nature and mastered by human, have woven their way throughout the entire history of human civilization. Recent developments in semiconducting polymer materials have further endowed fibers and textiles with various electronic functions, which are attractive in applications such as information interfacing, personalized medicine, and clean energy. Owing to their ability to be easily integrated into daily life, soft fiber electronics based on semiconducting polymers have gained popularity recently for wearable and implantable applications. Herein, we present a review of the previous and current progress in semiconducting polymer-based fiber electronics, particularly focusing on smart-wearable and implantable areas. First, we provide a brief overview of semiconducting polymers from the viewpoint of materials based on the basic concepts and functionality requirements of different devices. Then we analyze the existing applications and associated devices such as information interfaces, healthcare and medicine, and energy conversion and storage. The working principle and performance of semiconducting polymer-based fiber devices are summarized. Furthermore, we focus on the fabrication techniques of fiber devices. Based on the continuous fabrication of one-dimensional fiber and yarn, we introduce two-and three-dimensional fabric fabricating methods. Finally, we review challenges and relevant perspectives and potential solutions to address the related problems.

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“…Analogous trends have already been obtained on PEDOT-coated microthreads, [60] PEDOT-coated 3D-structured microelectrodes, [10] and PEDOT nanotubescovered electrodes. [61] The thermal noise can be extracted from these impedance measurements, for PtSi-and PEDOT:PSScoated electrodes (layer thickness 400 nm) following the method described in Section S3 (Supporting Information). The thermal noise is found to be slightly lower with PEDOT: PSS coated electrodes (4.10 μV ± 0.10 μV) that PtSi NWs-based electrodes (4.37 μV ± 0.29 μV).…”

Section: Electrochemical Impedance Spectroscopymentioning

confidence: 99%

Combining PEDOT:PSS Polymer Coating with Metallic 3D Nanowires Electrodes to Achieve High Electrochemical Performances for Neuronal Interfacing Applications

et al. 2023

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This study presents a novel approach to improve the performance of microelectrode arrays (MEAs) used for electrophysiological studies of neuronal networks. The integration of 3D nanowires (NWs) with MEAs increases the surface‐to‐volume ratio, which enables subcellular interactions and high‐resolution neuronal signal recording. However, these devices suffer from high initial interface impedance and limited charge transfer capacity due to their small effective area. To overcome these limitations, the integration of conductive polymer coatings, poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS) is investigated as a mean of improving the charge transfer capacity and biocompatibility of MEAs. The study combines platinum silicide‐based metallic 3D nanowires electrodes with electrodeposited PEDOT:PSS coatings to deposit ultra‐thin (<50 nm) layers of conductive polymer onto metallic electrodes with very high selectivity. The polymer‐coated electrodes were fully characterized electrochemically and morphologically to establish a direct relationship between synthesis conditions, morphology, and conductive features. Results show that PEDOT‐coated electrodes exhibit thickness‐dependent improved stimulation and recording performances, offering new perspectives for neuronal interfacing with optimal cell engulfment to enable the study of neuronal activity with acute spatial and signal resolution at the sub‐cellular level.

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Fabrication of vertically aligned PEDOT nanotube arrays on microelectrodes to interface neurons

Cited by 7 publications

References 46 publications

Simultaneous Presentation of Dexamethasone and Nerve Growth Factor via Layered Carbon Nanotubes and Polypyrrole to Interface Neural Cells

Simultaneous Presentation of Dexamethasone and Nerve Growth Factor via Layered Carbon Nanotubes and Polypyrrole to Interface Neural Cells

Soft Fiber Electronics Based on Semiconducting Polymer

Combining PEDOT:PSS Polymer Coating with Metallic 3D Nanowires Electrodes to Achieve High Electrochemical Performances for Neuronal Interfacing Applications

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