Fabrication of Three-Dimensional Composite Scaffold for Simultaneous Alveolar Bone Regeneration in Dental Implant Installation

Jeong, Hun‐Jin; Gwak, So‐Jung; Seo, Kyoung Duck; Lee, SaYa; Yun, Jin-Mun; Cho, Young‐Sam; Lee, Seung-Jae

doi:10.3390/ijms21051863

Cited by 30 publications

(26 citation statements)

References 40 publications

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“…Meanwhile in PCL composite scaffold group, it was assumed that the HA and β-TCP particles were primarily responsible for delivery of rhBMP-2, both because PCL has been reported to be relatively hydrophobic, and because a recent in vitro study conducted by our research group determined that the wettability of the PCL composite scaffold was significantly higher than that of the PCL scaffold without HA and β-TCP. 28 This study used experimental implants with a distinctive thread configuration, with the thread height in the apical part of implant being longer than that of the coronal part. This macroscopic thread design was opposite to the conventional typical tapered design.…”

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of 3D printed polycaprolactone composite scaffold and recombinant human bone morphogenetic protein‐2 for vertical bone augmentation with simultaneous implant placement on rabbit calvaria

Chang¹,

Lee

Jeong

et al. 2021

J Biomed Mater Res

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This study evaluated 3D printed polycaprolactone (PCL) composite scaffold and recombinant human bone morphogenetic protein-2 (rhBMP-2), loaded either onto a PCL composite scaffold or implant surface, for vertical bone augmentation with implant placement. Three-dimensional printed PCL frames were filled with powdered PCL, hydroxyapatite, and β-tricalcium phosphate. RhBMP-2 was loaded to the PCL composite scaffolds and implant surfaces, and rhBMP-2 release was quantified for 21 days. Experimental implants were placed bilaterally on 20 rabbit calvaria, and the PCL composite scaffolds were vertically augmented. The randomly allocated experimental groups were divided by carrier and rhBMP-2 dosage as no rhBMP-2 (control), 5 μg rhBMP-2 loaded to PCL composite (Scaffold/rhBMP-2[5 μg]), 5 μg rhBMP-2 loaded to implant (Implant/rhBMP-2[5 μg]), 30 μg rhBMP-2 loaded to PCL composite (Scaffold/rhBMP-2[30 μg]), and 30 μg rhBMP-2 loaded to implant (Implant/rhBMP-2 [30 μg]). Histologic and histometric analyses were conducted after 8 weeks. In both scaffold-loading and implant-loading, rhBMP-2 released initially rapidly, then slowly and constantly. Released rhBMP-2 totaled 23.02 ± 1.03% and 24.69 ± 1.14% in the scaffold-loaded and implant-loaded groups, respectively. There were no significant differences in histologic bone-implant contact (%). Peri-implant bone density (%) was significantly higher in the Scaffold/rhBMP-2(30 μg) and Implant/rhBMP-2(30 μg) groups. Total bone density (%) was not significantly different between the Scaffold/ rhBMP-2(5 μg), Implant/rhBMP-2(5 μg), and control groups, or between the Scaffold/rhBMP-2(30 μg) and Implant/rhBMP-2(30 μg) groups, but was significantly higher in the Scaffold/rhBMP-2(30 μg) and Implant/rhBMP-2(30 μg) groups than in the controls. Three-dimensional printed PCL composite scaffold with rhBMP-2 produced vertical osteogenesis and osseointegration, regardless of rhBMP-2 loading to the PCL composite scaffold or implant surface.Yun-Young Chang and Sa-Ya Lee contributed equally to this study.

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Section: Discussionmentioning

confidence: 99%

In vivo evaluation of 3D printed polycaprolactone composite scaffold and recombinant human bone morphogenetic protein‐2 for vertical bone augmentation with simultaneous implant placement on rabbit calvaria

Chang¹,

Lee

Jeong

et al. 2021

J Biomed Mater Res

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“…Another option is the incorporation of TCP into the PCL. In recent years, a novel hybrid scaffold composed of a three-dimensionally (3D) printed polycaprolactone (PCL) HA/β-TCP scaffold was developed with simultaneous implant fixtures use in mind [ 119 ]. Clinically, another novel 3D printed PCL-TCP (Osteo-plug ® ; Ostepore International, Singapore) device for ridge preservation has been tested and is in the midst of undergoing further clinical trials.…”

Section: Polymer-based Bone Substitutesmentioning

confidence: 99%

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

et al. 2021

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Alloplasts are synthetic, inorganic, biocompatible bone substitutes that function as defect fillers to repair skeletal defects. The acceptance of these substitutes by host tissues is determined by the pore diameter and the porosity and inter-connectivity. This narrative review appraises recent developments, characterization, and biological performance of different synthetic materials for bone, periodontal, and dental tissue regeneration. They include calcium phosphate cements and their variants β-tricalcium phosphate (β-TCP) ceramics and biphasic calcium phosphates (hydroxyapatite (HA) and β-TCP ceramics), calcium sulfate, bioactive glasses and polymer-based bone substitutes which include variants of polycaprolactone. In summary, the search for synthetic bone substitutes remains elusive with calcium compounds providing the best synthetic substitute. The combination of calcium sulphate and β-TCP provides improved handling of the materials, dispensing with the need for a traditional membrane in guided bone regeneration. Evidence is supportive of improved angiogenesis at the recipient sites. One such product, (EthOss® Regeneration, Silesden UK) has won numerous awards internationally as a commercial success. Bioglasses and polymers, which have been used as medical devices, are still in the experimental stage for dental application. Polycaprolactone-TCP, one of the products in this category is currently undergoing further randomized clinical trials as a 3D socket preservation filler. These aforementioned products may have vast potential for substituting human/animal-based bone grafts.

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“…Despite numerous evidence-based efforts to preserve alveolar bone, minimal vertical bone resorption has been found to be unpredictable. Although there are positive results in the prevention of horizontal resorption of the alveolar ridge, further research is needed to prevent vertical resorption of the alveolar part of the mandible 29,30 . Depending on the indication, the size of the defect in the bone, the location of the defect, etc., surgeons will choose the procedure and type of membrane that will give the best results in relation to atrophy of the alveolar ridge of the mandible and the possible occurrence of inflammatory complications.…”

Section: Discussionmentioning

confidence: 99%

Application of bio-resorbable membranes in preventing complications of lower jaw surgery

Tušek¹,

Pohodenko-Chudakova²,

Nikolaevna

et al. 2022

Balkan J Dent Med

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Summary Background/Aim: Prevention of inflammation and alveolar bone atrophy is very important in oral surgery. The aim of this study was to compare the use of two osteoplastic bio-resorbable membranes in order to prevent inflammatory complications and atrophy of the alveolar part of the mandible after surgical interventions. Material and Methods: We examined 86 patients 45-70 years old who were classified into four groups. In group 1, there were 21 patients who had a “bio-resorbable membrane type 1 implanted. The group 2 consisted of 23 persons treated with bio-resorbable membrane type 2. Only the occurrence of inflammatory complications after the placement of these membranes was monitored. Group 3 included 20 persons treated with membrane type 1 and group 4 included 22 patients treated with membrane type 2 to prevent both inflammatory complications and atrophy of the alveolar part of the mandible. The level of atrophy of the alveolar bone after one year was determined by cone-beam computed tomography. The obtained data were statistically evaluated. Results: Six inflammatory complications (“dry socket”) have been identified in operated patients treated with a membrane type 1 (the first and the third groups). Only two “dry socket” occurred in patients treated with membrane type 2 (the second and fourth groups). Group 4 had significant advantages in the alveolar crest height 14.6 (11.2-22.3) and in its width 7.7 (5.1-10.2) both in relation to the indices of group 3 (11.1 (9.7-20.4) and 6.2 (4.2-9.0). Conclusions: The bio-resorbable membrane type 2 prevented inflammatory complications in the short postoperative period after surgical interventions, as well as, the atrophy of the mandible.

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Fabrication of Three-Dimensional Composite Scaffold for Simultaneous Alveolar Bone Regeneration in Dental Implant Installation

Cited by 30 publications

References 40 publications

In vivo evaluation of 3D printed polycaprolactone composite scaffold and recombinant human bone morphogenetic protein‐2 for vertical bone augmentation with simultaneous implant placement on rabbit calvaria

In vivo evaluation of 3D printed polycaprolactone composite scaffold and recombinant human bone morphogenetic protein‐2 for vertical bone augmentation with simultaneous implant placement on rabbit calvaria

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

Application of bio-resorbable membranes in preventing complications of lower jaw surgery

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