Fabrication of thermoset polymer nanofibers by co-electrospinning of uniform core-shell structures

Reddy, Chaganti Srinivasa; Arinstein, Arkadii; Avrahami, Ron; Zussman, Eyal

doi:10.1039/b916185f

Cited by 27 publications

(29 citation statements)

References 16 publications

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“…In addition, these elements are both non‐toxic and non‐immunogenic, which are two essential requirements for biocompatible implantable materials. Photopolymerization of this oligomer leads to the formation of flexible elastomeric hydrogel films and nanofibers . Assessment of the tissue engineering capacities of the described compound fiber scaffolds embedded with rabbit cardiac cells, demonstrated their low stiffness and balanced hydrophobic properties were suitable for cell adhesion and proliferation of cardiac cells.…”

Section: Introductionmentioning

confidence: 99%

Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering

Reddy

Venugopal

Ramakrishna

et al. 2013

J Biomedical Materials Res

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Polycaprolactone (PCL), a synthetic biocompatible and biodegradable polymer generally used as a scaffold material for tissue engineering applications. The high stiffness and hydrophobicity of the PCL fiber mesh does not provide significant cell attachment and proliferation in cardiac tissue engineering. Towards this goal, the study focused on a compound of PCL and oligomer hydrogel [Bisphenol A ethoxylated dimethacrylate (BPAEDMA)] processed into electrospun nanofibrous scaffolds. The composition, morphology and mechanical properties of the compound scaffolds, composed of varying ratios of PCL and hydrogel were characterized by scanning electron microscopy, infrared spectroscopy and dynamic mechanical analyzer. The elastic modulus of PCL/BPAEDMA nanofibrous scaffolds was shown to be varying the BPAEDMA weight fraction and was decreased by increasing the BPAEDMA weight fraction. Compound fiber meshes containing 75 wt % BPAEDMA oligomer hydrogel exhibited lower modulus (3.55 MPa) and contact angle of 25(o) . Rabbit cardiac cells cultured for 10 days on these PCL/BPAEDMA compound nanofibrous scaffolds remained viable and expressed cardiac troponin and alpha-actinin proteins for the normal functioning of myocardium. Cell adhesion and proliferations were significantly increased on compound fiber meshes containing 75 wt % BPAEDMA, when compared with other nanofibrous scaffolds. The results observed that the produced PCL/BPAEDMA compound nanofibrous scaffolds promote cell adhesion, proliferation and normal functioning of cardiac cells to clinically beneficial levels, relevant for cardiac tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering

Reddy

Venugopal

Ramakrishna

et al. 2013

J Biomedical Materials Res

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“…In addition, these elements are both non-toxic and non-immunogenic, which are two essential requirements for biocompatible implantable materials. Photopolymerization of this oligomer led to the formation of flexible elastomeric hydrogel films and nanofibers [82]. Rabbit CMs cultured for 10 days on these PCL/ BPAEDMA scaffolds, remained viable and expressed cardiac troponin and alpha-actinin proteins for the normal functioning of myocardium, where cell adhesion and proliferation were significantly increased on scaffolds containing 75 wt % BPAEDMA.…”

Section: Poly(ε-caprolactone)-based Scaffoldsmentioning

confidence: 99%

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

et al. 2017

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Please cite this article as: Kitsara, M., Agbulut, O., Kontziampasis, D., Chen, Y., Menasché, P., Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering, Acta Biomaterialia (2016), doi: http://dx.doi.org/ 10. 1016/j.actbio.2016.11.014 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractCardiac cell therapy holds a real promise for improving heart function and especially of the chronically failing myocardium. Embedding cells into 3D biodegradable scaffolds may better preserve cell survival and enhance cell engraftment after transplantation, consequently improving cardiac cell therapy compared with direct intramyocardial injection of isolated cells.The primary objective of a scaffold used in tissue engineering is the recreation of the natural 3D environment most suitable for an adequate tissue growth. An important aspect of this commitment is to mimic the fibrillar structure of the extracellular matrix, which provides essential guidance for cell organization, survival, and function. Recent advances in nanotechnology have significantly improved our capacities to mimic the extracellular matrix. Among them, electrospinning is well known for being easy to process and cost effective. Consequently, it is becoming increasingly popular for biomedical applications and it is most definitely the cutting edge technique to make scaffolds that mimic the extracellular matrix for industrial applications.Here, the desirable physico-chemical properties of the electrospun scaffolds for cardiac therapy are described, and polymers are categorized to natural and synthetic. Moreover, the methods used for improving functionalities by providing cells with the necessary chemical cues and a more in vivo-like environment are reported.

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“…Reddy et al derived a method of 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 determining the kinetics as a size-dependent framework for oligomeric systems under confinement [36]. (Kindly refer Supplementary Information File) It was postulated that when the mean size of the clusters attains the diameter of the fiber core, the fiber core will be separated into a large number of slugs consisting of non-polymerized oligomer.…”

Section: Theoritcal Model Of Kineticsmentioning

confidence: 99%

“…The incorporation of PVA to the mixture in the weight ratio of 1:1, renders the system excellent spinnability along with a prominent core-sheath structure. Generally, a co-axial system of electrospinning is approached for the formation of core and shell fibers, but the present system spins a well dispersed solution of PVA and water with an oligomeric precursor of RF(catalyzed by NaOH), (Batch D) (Fig 6) [36]. The oligomeric liquid gets encapsulated inside the polymeric shell which can be cured in oven post spinning, followed by dissolving the shell to ensure fiber formation of RF, or can be carbonized as such.…”

Section: B Effect Of Humiditymentioning

confidence: 99%

Nanoencapsulated Core and Shell Electrospun Fibers of Resorcinol Formaldehyde

Badhe

Kandasubramanian

2015

Ind. Eng. Chem. Res.

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A facile and efficient method of inducing nanofibers of thermosetting resins by electrospinning has been established. The study involves extensive exploitation of unconventional parameters of electrospinning, viz. temperature ranging from 10 to 40°C, humidity of 19% and 75% RH, concentration and type of catalyst( 0.1 N NaOH and 0.1 N Hexamine), which affect the morphology of the fibers and a clear comparison using FESEM imaging. The instability of the Resorcinol Formaldehyde towards electrospinning has been overcome by introducing coresheath approach using 10% PVA solution in 1:1 ratio, pertaining to the molecular migration by the virtue of presence of charged ions with a core of 345 nm and 108 nm shell. Thus-formed fibers can be carbonized to generate carbon fibers with high carbon yield and better dimensional stability to find potential in next generation heat exchangers and chillers.

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Fabrication of thermoset polymer nanofibers by co-electrospinning of uniform core-shell structures

Cited by 27 publications

References 16 publications

Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering

Polycaprolactone/oligomer compound scaffolds for cardiac tissue engineering

Fibers for hearts: A critical review on electrospinning for cardiac tissue engineering

Nanoencapsulated Core and Shell Electrospun Fibers of Resorcinol Formaldehyde

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