Fabrication of thermoresponsive micelles by functionalizing hydroxypropyl cellulose via azide‐alkyne click reaction
Haoying Wang,
Fangyu Wang,
Jinping Zhou
Abstract:In this work, we functionalized hydroxypropyl cellulose (HPC) by attaching tetraphenylethylene (TPE) via copper‐catalyzed azide‐alkyne cycloaddition (CuAAC). The obtained HPC‐TPE samples displayed water‐solubility, biocompatibility, fluorescence and thermoresponsive properties. The degree of substitution (DSTPE) of HPC‐TPE1 ~ 4 was determined to be 0.002, 0.006, 0.025, and 0.053, respectively. HPC‐TPE could self‐assemble into micelles in water with the hydrodynamic radius (Rh) ranging from 164 to 190 nm. Under… Show more
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