Fabrication of Tamarindus indica seeds extract loaded-cream for photo-aged skin: Visioscan® studies

Abstract

IntroductionIntracellular and extracellular oxidative stress triggered by free radicals promotes skin aging, which is designated by atypical pigmentation and wrinkles. The consumption of antioxidants is an efficacious measure to avert symptoms involved in skin aging.AimThe current research was commenced to explore the anti-aging potential of antioxidants present in Tamarindus indica seeds extract.Material and methods Tamarindus indica seeds extract was obtained by concentrating the ethanolic extract of seeds. The antioxidant activities of the extract were measured by nitric oxide radical scavenging assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, hydroxyl radical scavenging assay and superoxide radical scavenging assay. Formulation comprising 4% of the concentrated extract of seeds was formulated by loading it in the internal aqueous phase of water-in-oil (W/O) cosmetic emulsion. The base, used as control, consisted of the same emulsion but without loading Tamarindus indica seeds extract. The cosmetic emulsions were applied to the cheeks of 11 healthy male volunteers for duration of 12 weeks. Both base and formulation were assessed for their antioxidant effects on different skin parameters i.e. skin moisture contents, elasticity and surface evaluation of living skin (SELS).ResultsThe formulation showed statistically significant (p ≤ 0.05) and the base showed insignificant (p > 0.05) effects on skin elasticity and skin moisture contents. There is a significant decline in SELS, skin scaliness (SEsc), skin wrinkles (SEw), skin smoothness (SEsm), and skin roughness (SEr) parameters after application of the formulation.ConclusionsTopical application of the cosmetic emulsion entrapped with Tamarindus indica seeds extract containing various antioxidants exerts potential skin antiaging effects.

Formulation Development and Facial Skin Evaluation of Serum Containing Jellose from Tamarind Seeds

“…The good properties of tamarind jellose serum that was developed in this study makes it attractive as a cosmeceutical product, that can be used for antiaging and skin lightening [17][18]. Furthermore, our findings were similar to the findings of Waqas, et al [19], where they used tamarind seed extract in the formulation for improving photo-aged skin. Their formulation reduced the fine wrinkles and improved the appearance of the skin.…”

A composite carbon-based solid acid-supported palladium catalyst (Pd/C-SO3H) for hydrogenolysis of plant-derived polymeric proanthocyanidins

“…Aer standing in the dark for 30 min, the absorbance was measured at 517 nm using a UV-Vis spectrophotometer. 28,29 Aqueous ethanol (70% v/v) was used as the control. The DPPHc scavenging ability was calculated using formula (4):…”

Characterization and Pharmacological Evaluation of Anti-Cellulite Herbal Product(s) Encapsulated in 3D-Fabricated Polymeric Microneedles

“…These activities are associated with high levels of phenolics, flavonoids 30 , fatty acid and mineral contents 31 . A water/oil emulsion formulation loaded with T. indica seed extract showed an effective anti-aging potential that was well correlated with a high antioxidant effect 32 . Vitex agnus-castus L. (Verbenaceae), or chaste tree, has a long history of being used to treat gastro-intestinal disorders, as a diuretic and as an anti-anxiety medication, in addition to the previously reported use of the fruits of V. agnus-castus in treating gynaecological disorders 33 .…”

“…Tamarindus indica L. (Fabaceae) is a fascinating plant with various applications in folk medicine and is used to treat rheumatism, cough and jaundice. T. indica (leaf, seeds and fruits) exhibited strong antioxidant [24][25][26] , anti-inflammatory 27 , hepatoprotective 28 and hypolipidaemic 29 effects. These activities are associated with high levels of phenolics, flavonoids 30 , fatty acid and mineral contents 31 .…”